Exosome component 5

Exosome component 5
PDB rendering based on 2nn6.
Available structures PDB 2nn6
Identifiers
Symbols	EXOSC5; MGC111224; MGC12901; RRP41B; RRP46; Rrp46p; hRrp46p; p12B
External IDs	OMIM: 606492 MGI: 107889 HomoloGene: 5981 GeneCards: EXOSC5 Gene
Gene Ontology Molecular function • 3'-5'-exoribonuclease activity • RNA binding • exoribonuclease activity • protein binding Cellular component • exosome (RNase complex) • nucleus • nucleolus • cytoplasm • cytosol • transcriptionally active chromatin Biological process • nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay • rRNA processing • RNA processing • RNA metabolic process • mRNA metabolic process • exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay • exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay • DNA deamination Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	56915	27998
Ensembl	ENSG00000077348	ENSMUSG00000061286
UniProt	Q9NQT4	Q3U2K4
RefSeq (mRNA)	NM_020158	NM_138586.3
RefSeq (protein)	NP_064543	NP_613052.1
Location (UCSC)	Chr 19: 41.89 – 41.9 Mb	Chr 7: 26.44 – 26.45 Mb
PubMed search	[1]	[2]

Exosome component 5, also known as EXOSC5, is a human gene, which is part of the exosome complex.

Interactions

Exosome component 5 has been shown to interact with Exosome component 8 and Exosome component 1.

Further reading

• Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery.". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548. 
• Allmang C, Petfalski E, Podtelejnikov A, et al. (1999). "The yeast exosome and human PM-Scl are related complexes of 3' --> 5' exonucleases.". Genes Dev. 13 (16): 2148–58. doi:10.1101/gad.13.16.2148. PMC 316947. PMID 10465791. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=316947. 
• Brouwer R, Allmang C, Raijmakers R, et al. (2001). "Three novel components of the human exosome.". J. Biol. Chem. 276 (9): 6177–84. doi:10.1074/jbc.M007603200. PMID 11110791. 
• Chen CY, Gherzi R, Ong SE, et al. (2002). "AU binding proteins recruit the exosome to degrade ARE-containing mRNAs.". Cell 107 (4): 451–64. doi:10.1016/S0092-8674(01)00578-5. PMID 11719186. 
• Raijmakers R, Noordman YE, van Venrooij WJ, Pruijn GJ (2002). "Protein-protein interactions of hCsl4p with other human exosome subunits.". J. Mol. Biol. 315 (4): 809–18. doi:10.1006/jmbi.2001.5265. PMID 11812149. 
• Brouwer R, Vree Egberts WT, Hengstman GJ, et al. (2002). "Autoantibodies directed to novel components of the PM/Scl complex, the human exosome.". Arthritis Res. 4 (2): 134–8. doi:10.1186/ar389. PMC 83843. PMID 11879549. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=83843. 
• Yang XF, Wu CJ, Chen L, et al. (2002). "CML28 is a broadly immunogenic antigen, which is overexpressed in tumor cells.". Cancer Res. 62 (19): 5517–22. PMID 12359762. 
• Raijmakers R, Egberts WV, van Venrooij WJ, Pruijn GJ (2002). "Protein-protein interactions between human exosome components support the assembly of RNase PH-type subunits into a six-membered PNPase-like ring.". J. Mol. Biol. 323 (4): 653–63. doi:10.1016/S0022-2836(02)00947-6. PMID 12419256. 
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241. 
• Lehner B, Sanderson CM (2004). "A protein interaction framework for human mRNA degradation.". Genome Res. 14 (7): 1315–23. doi:10.1101/gr.2122004. PMC 442147. PMID 15231747. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=442147. 
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928. 
• Andersen JS, Lam YW, Leung AK, et al. (2005). "Nucleolar proteome dynamics.". Nature 433 (7021): 77–83. doi:10.1038/nature03207. PMID 15635413. 
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514. 
• Zhou H, Zhang D, Wang Y, et al. (2006). "Induction of CML28-specific cytotoxic T cell responses using co-transfected dendritic cells with CML28 DNA vaccine and SOCS1 small interfering RNA expression vector.". Biochem. Biophys. Res. Commun. 347 (1): 200–7. doi:10.1016/j.bbrc.2006.06.093. PMID 16815301. 
• Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.". Cell 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.