Ezrin

Ezrin
	; PDB rendering based on 1ni2.
Available structures
PDB	1ni2
Identifiers
Symbols	EZR; CVIL; CVL; DKFZp762H157; FLJ26216; MGC1584; VIL2
External IDs	OMIM: 123900 MGI: 98931 HomoloGene: 55740 GeneCards: EZR Gene
Gene Ontology
Molecular function	• protein binding; • cytoskeletal protein binding; • cell adhesion molecule binding; • actin filament binding;
Cellular component	• ruffle; • uropod; • intracellular; • nucleolus; • cytoplasm; • cytosol; • cytosol; • cytosol; • actin filament; • plasma membrane; • microvillus; • microvillus; • focal adhesion; • microtubule basal body; • cell cortex; • actin cytoskeleton; • basolateral plasma membrane; • apical plasma membrane; • extrinsic to membrane; • filopodium; • cortical cytoskeleton; • microvillus membrane; • ruffle membrane; • apical part of cell;
Biological process	• cytoskeletal anchoring at plasma membrane; • leukocyte cell-cell adhesion; • axon guidance; • regulation of cell shape; • membrane to membrane docking; • epithelial cell differentiation; • establishment or maintenance of apical/basal cell polarity; • actin filament bundle assembly;
	Sources: Amigo / QuickGO
RNA expression pattern
	More reference expression data
Orthologs

From Wikipedia, the free encyclopedia

Jump to: navigation, search

Ezrin also known as cytovillin or villin-2 is a protein that in humans is encoded by the EZR gene.^[1]

The cytoplasmic peripheral membrane protein encoded by this gene functions as a protein-tyrosine kinase substrate in microvilli. As a member of the ERM protein family, this protein serves as an intermediate between the plasma membrane and the actin cytoskeleton. It plays a key role in cell surface structure adhesion, migration, and organization.^[2]

[edit] Interactions

VIL2 has been shown to interact with Sodium-hydrogen exchange regulatory cofactor 2,^[3]^[4] Merlin,^[5] SDC2,^[6] CD43,^[7] Fas ligand,^[8]^[9] VCAM-1,^[10] S100P,^[11] ICAM3,^[12]^[13] ICAM-1,^[12] Sodium-hydrogen antiporter 3 regulator 1,^[14]^[15] ICAM2,^[12] Moesin,^[8]^[16]^[17] PALLD^[18] and PIK3R1.^[19]

[edit] References

^ Gould KL, Bretscher A, Esch FS, Hunter T (December 1989). "cDNA cloning and sequencing of the protein-tyrosine kinase substrate, ezrin, reveals homology to band 4.1". EMBO J. 8 (13): 4133–42. PMC 401598. PMID 2591371. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=401598.
^ "Entrez Gene: VIL2 villin 2 (ezrin)". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7430.
^ Yun, C H; Lamprecht G, Forster D V, Sidor A (Oct. 1998). "NHE3 kinase A regulatory protein E3KARP binds the epithelial brush border Na+/H+ exchanger NHE3 and the cytoskeletal protein ezrin". J. Biol. Chem. (UNITED STATES) 273 (40): 25856–63. doi:10.1074/jbc.273.40.25856. ISSN 0021-9258. PMID 9748260.
^ Sitaraman, Shanthi V; Wang Lixin, Wong Michelle, Bruewer Matthias, Hobert Michael, Yun C-H, Merlin Didier, Madara James L (Sep. 2002). "The adenosine 2b receptor is recruited to the plasma membrane and associates with E3KARP and Ezrin upon agonist stimulation". J. Biol. Chem. (United States) 277 (36): 33188–95. doi:10.1074/jbc.M202522200. ISSN 0021-9258. PMID 12080047.
^ Grönholm, M; Sainio M, Zhao F, Heiska L, Vaheri A, Carpén O (Mar. 1999). "Homotypic and heterotypic interaction of the neurofibromatosis 2 tumor suppressor protein merlin and the ERM protein ezrin". J. Cell. Sci. (ENGLAND) 112 (6): 895–904. ISSN 0021-9533. PMID 10036239.
^ Granés, F; Urena J M, Rocamora N, Vilaró S (Apr. 2000). "Ezrin links syndecan-2 to the cytoskeleton". J. Cell. Sci. (ENGLAND) 113 (7): 1267–76. ISSN 0021-9533. PMID 10704377.
^ Serrador, J M; Nieto M, Alonso-Lebrero J L, del Pozo M A, Calvo J, Furthmayr H, Schwartz-Albiez R, Lozano F, González-Amaro R, Sánchez-Mateos P, Sánchez-Madrid F (Jun. 1998). "CD43 interacts with moesin and ezrin and regulates its redistribution to the uropods of T lymphocytes at the cell-cell contacts". Blood (UNITED STATES) 91 (12): 4632–44. ISSN 0006-4971. PMID 9616160.
^ ^a ^b Gajate, Consuelo; Mollinedo Faustino (Mar. 2005). "Cytoskeleton-mediated death receptor and ligand concentration in lipid rafts forms apoptosis-promoting clusters in cancer chemotherapy". J. Biol. Chem. (United States) 280 (12): 11641–7. doi:10.1074/jbc.M411781200. ISSN 0021-9258. PMID 15659383.
^ Parlato, S; Giammarioli A M, Logozzi M, Lozupone F, Matarrese P, Luciani F, Falchi M, Malorni W, Fais S (Oct. 2000). "CD95 (APO-1/Fas) linkage to the actin cytoskeleton through ezrin in human T lymphocytes: a novel regulatory mechanism of the CD95 apoptotic pathway". EMBO J. (ENGLAND) 19 (19): 5123–34. doi:10.1093/emboj/19.19.5123. ISSN 0261-4189. PMC 302100. PMID 11013215. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=302100.
^ Barreiro, Olga; Yanez-Mo Maria, Serrador Juan M, Montoya Maria C, Vicente-Manzanares Miguel, Tejedor Reyes, Furthmayr Heinz, Sanchez-Madrid Francisco (Jun. 2002). "Dynamic interaction of VCAM-1 and ICAM-1 with moesin and ezrin in a novel endothelial docking structure for adherent leukocytes". J. Cell Biol. (United States) 157 (7): 1233–45. doi:10.1083/jcb.200112126. ISSN 0021-9525. PMC 2173557. PMID 12082081. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2173557.
^ Koltzscher, Max; Neumann Claudia, König Simone, Gerke Volker (Jun. 2003). "Ca2+-dependent binding and activation of dormant ezrin by dimeric S100P". Mol. Biol. Cell (United States) 14 (6): 2372–84. doi:10.1091/mbc.E02-09-0553. ISSN 1059-1524. PMC 194886. PMID 12808036. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=194886.
^ ^a ^b ^c Heiska, L; Alfthan K, Grönholm M, Vilja P, Vaheri A, Carpén O (Aug. 1998). "Association of ezrin with intercellular adhesion molecule-1 and -2 (ICAM-1 and ICAM-2). Regulation by phosphatidylinositol 4, 5-bisphosphate". J. Biol. Chem. (UNITED STATES) 273 (34): 21893–900. doi:10.1074/jbc.273.34.21893. ISSN 0021-9258. PMID 9705328.
^ Serrador, Juan M; Vicente-Manzanares Miguel, Calvo Javier, Barreiro Olga, Montoya Maria C, Schwartz-Albiez Reinhard, Furthmayr Heinz, Lozano Francisco, Sánchez-Madrid Francisco (Mar. 2002). "A novel serine-rich motif in the intercellular adhesion molecule 3 is critical for its ezrin/radixin/moesin-directed subcellular targeting". J. Biol. Chem. (United States) 277 (12): 10400–9. doi:10.1074/jbc.M110694200. ISSN 0021-9258. PMID 11784723.
^ Brdicková, N; Brdicka T, Andera L, Spicka J, Angelisová P, Milgram S L, Horejsí V (Oct. 2001). "Interaction between two adapter proteins, PAG and EBP50: a possible link between membrane rafts and actin cytoskeleton". FEBS Lett. (Netherlands) 507 (2): 133–6. doi:10.1016/S0014-5793(01)02955-6. ISSN 0014-5793. PMID 11684085.
^ Reczek, D; Berryman M, Bretscher A (Oct. 1997). "Identification of EBP50: A PDZ-containing phosphoprotein that associates with members of the ezrin-radixin-moesin family". J. Cell Biol. (UNITED STATES) 139 (1): 169–79. doi:10.1083/jcb.139.1.169. ISSN 0021-9525. PMC 2139813. PMID 9314537. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2139813.
^ Gary, R; Bretscher A (Aug. 1995). "Ezrin self-association involves binding of an N-terminal domain to a normally masked C-terminal domain that includes the F-actin binding site". Mol. Biol. Cell (UNITED STATES) 6 (8): 1061–75. ISSN 1059-1524. PMC 301263. PMID 7579708. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=301263.
^ Gary, R; Bretscher A (Nov. 1993). "Heterotypic and homotypic associations between ezrin and moesin, two putative membrane-cytoskeletal linking proteins". Proc. Natl. Acad. Sci. U.S.A. (UNITED STATES) 90 (22): 10846–50. doi:10.1073/pnas.90.22.10846. ISSN 0027-8424. PMC 47875. PMID 8248180. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=47875.
^ Mykkänen, O M; Grönholm M, Rönty M, Lalowski M, Salmikangas P, Suila H, Carpén O (Oct. 2001). "Characterization of human palladin, a microfilament-associated protein". Mol. Biol. Cell (United States) 12 (10): 3060–73. ISSN 1059-1524. PMC 60155. PMID 11598191. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=60155.
^ Gautreau, A; Poullet P, Louvard D, Arpin M (Jun. 1999). "Ezrin, a plasma membrane-microfilament linker, signals cell survival through the phosphatidylinositol 3-kinase/Akt pathway". Proc. Natl. Acad. Sci. U.S.A. (UNITED STATES) 96 (13): 7300–5. doi:10.1073/pnas.96.13.7300. ISSN 0027-8424. PMC 22080. PMID 10377409. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=22080.

[edit] Further reading

Martin TA, Harrison G, Mansel RE, Jiang WG (2004). "The role of the CD44/ezrin complex in cancer metastasis.". Crit. Rev. Oncol. Hematol. 46 (2): 165–86. doi:10.1016/S1040-8428(02)00172-5. PMID 12711360.

This article on a gene on chromosome 6 is a stub. You can help Wikipedia by expanding it.

[pmid2591371-0] Gould KL, Bretscher A, Esch FS, Hunter T (December 1989). "cDNA cloning and sequencing of the protein-tyrosine kinase substrate, ezrin, reveals homology to band 4.1". EMBO J. 8 (13): 4133–42. PMC 401598. PMID 2591371. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=401598.

[1] "Entrez Gene: VIL2 villin 2 (ezrin)". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7430.

[pmid9748260-2] Yun, C H; Lamprecht G, Forster D V, Sidor A (Oct. 1998). "NHE3 kinase A regulatory protein E3KARP binds the epithelial brush border Na+/H+ exchanger NHE3 and the cytoskeletal protein ezrin". J. Biol. Chem. (UNITED STATES) 273 (40): 25856–63. doi:10.1074/jbc.273.40.25856. ISSN 0021-9258. PMID 9748260.

[pmid12080047-3] Sitaraman, Shanthi V; Wang Lixin, Wong Michelle, Bruewer Matthias, Hobert Michael, Yun C-H, Merlin Didier, Madara James L (Sep. 2002). "The adenosine 2b receptor is recruited to the plasma membrane and associates with E3KARP and Ezrin upon agonist stimulation". J. Biol. Chem. (United States) 277 (36): 33188–95. doi:10.1074/jbc.M202522200. ISSN 0021-9258. PMID 12080047.

[pmid10036239-4] Grönholm, M; Sainio M, Zhao F, Heiska L, Vaheri A, Carpén O (Mar. 1999). "Homotypic and heterotypic interaction of the neurofibromatosis 2 tumor suppressor protein merlin and the ERM protein ezrin". J. Cell. Sci. (ENGLAND) 112 (6): 895–904. ISSN 0021-9533. PMID 10036239.

[pmid10704377-5] Granés, F; Urena J M, Rocamora N, Vilaró S (Apr. 2000). "Ezrin links syndecan-2 to the cytoskeleton". J. Cell. Sci. (ENGLAND) 113 (7): 1267–76. ISSN 0021-9533. PMID 10704377.

[pmid9616160-6] Serrador, J M; Nieto M, Alonso-Lebrero J L, del Pozo M A, Calvo J, Furthmayr H, Schwartz-Albiez R, Lozano F, González-Amaro R, Sánchez-Mateos P, Sánchez-Madrid F (Jun. 1998). "CD43 interacts with moesin and ezrin and regulates its redistribution to the uropods of T lymphocytes at the cell-cell contacts". Blood (UNITED STATES) 91 (12): 4632–44. ISSN 0006-4971. PMID 9616160.

[pmid15659383-7] Gajate, Consuelo; Mollinedo Faustino (Mar. 2005). "Cytoskeleton-mediated death receptor and ligand concentration in lipid rafts forms apoptosis-promoting clusters in cancer chemotherapy". J. Biol. Chem. (United States) 280 (12): 11641–7. doi:10.1074/jbc.M411781200. ISSN 0021-9258. PMID 15659383.

[pmid11013215-8] Parlato, S; Giammarioli A M, Logozzi M, Lozupone F, Matarrese P, Luciani F, Falchi M, Malorni W, Fais S (Oct. 2000). "CD95 (APO-1/Fas) linkage to the actin cytoskeleton through ezrin in human T lymphocytes: a novel regulatory mechanism of the CD95 apoptotic pathway". EMBO J. (ENGLAND) 19 (19): 5123–34. doi:10.1093/emboj/19.19.5123. ISSN 0261-4189. PMC 302100. PMID 11013215. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=302100.

[pmid12082081-9] Barreiro, Olga; Yanez-Mo Maria, Serrador Juan M, Montoya Maria C, Vicente-Manzanares Miguel, Tejedor Reyes, Furthmayr Heinz, Sanchez-Madrid Francisco (Jun. 2002). "Dynamic interaction of VCAM-1 and ICAM-1 with moesin and ezrin in a novel endothelial docking structure for adherent leukocytes". J. Cell Biol. (United States) 157 (7): 1233–45. doi:10.1083/jcb.200112126. ISSN 0021-9525. PMC 2173557. PMID 12082081. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2173557.

[pmid12808036-10] Koltzscher, Max; Neumann Claudia, König Simone, Gerke Volker (Jun. 2003). "Ca2+-dependent binding and activation of dormant ezrin by dimeric S100P". Mol. Biol. Cell (United States) 14 (6): 2372–84. doi:10.1091/mbc.E02-09-0553. ISSN 1059-1524. PMC 194886. PMID 12808036. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=194886.

[pmid9705328-11] Heiska, L; Alfthan K, Grönholm M, Vilja P, Vaheri A, Carpén O (Aug. 1998). "Association of ezrin with intercellular adhesion molecule-1 and -2 (ICAM-1 and ICAM-2). Regulation by phosphatidylinositol 4, 5-bisphosphate". J. Biol. Chem. (UNITED STATES) 273 (34): 21893–900. doi:10.1074/jbc.273.34.21893. ISSN 0021-9258. PMID 9705328.

[pmid11784723-12] Serrador, Juan M; Vicente-Manzanares Miguel, Calvo Javier, Barreiro Olga, Montoya Maria C, Schwartz-Albiez Reinhard, Furthmayr Heinz, Lozano Francisco, Sánchez-Madrid Francisco (Mar. 2002). "A novel serine-rich motif in the intercellular adhesion molecule 3 is critical for its ezrin/radixin/moesin-directed subcellular targeting". J. Biol. Chem. (United States) 277 (12): 10400–9. doi:10.1074/jbc.M110694200. ISSN 0021-9258. PMID 11784723.

[pmid11684085-13] Brdicková, N; Brdicka T, Andera L, Spicka J, Angelisová P, Milgram S L, Horejsí V (Oct. 2001). "Interaction between two adapter proteins, PAG and EBP50: a possible link between membrane rafts and actin cytoskeleton". FEBS Lett. (Netherlands) 507 (2): 133–6. doi:10.1016/S0014-5793(01)02955-6. ISSN 0014-5793. PMID 11684085.

[pmid9314537-14] Reczek, D; Berryman M, Bretscher A (Oct. 1997). "Identification of EBP50: A PDZ-containing phosphoprotein that associates with members of the ezrin-radixin-moesin family". J. Cell Biol. (UNITED STATES) 139 (1): 169–79. doi:10.1083/jcb.139.1.169. ISSN 0021-9525. PMC 2139813. PMID 9314537. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2139813.

[pmid7579708-15] Gary, R; Bretscher A (Aug. 1995). "Ezrin self-association involves binding of an N-terminal domain to a normally masked C-terminal domain that includes the F-actin binding site". Mol. Biol. Cell (UNITED STATES) 6 (8): 1061–75. ISSN 1059-1524. PMC 301263. PMID 7579708. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=301263.

[pmid8248180-16] Gary, R; Bretscher A (Nov. 1993). "Heterotypic and homotypic associations between ezrin and moesin, two putative membrane-cytoskeletal linking proteins". Proc. Natl. Acad. Sci. U.S.A. (UNITED STATES) 90 (22): 10846–50. doi:10.1073/pnas.90.22.10846. ISSN 0027-8424. PMC 47875. PMID 8248180. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=47875.

[pmid11598191-17] Mykkänen, O M; Grönholm M, Rönty M, Lalowski M, Salmikangas P, Suila H, Carpén O (Oct. 2001). "Characterization of human palladin, a microfilament-associated protein". Mol. Biol. Cell (United States) 12 (10): 3060–73. ISSN 1059-1524. PMC 60155. PMID 11598191. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=60155.

[pmid10377409-18] Gautreau, A; Poullet P, Louvard D, Arpin M (Jun. 1999). "Ezrin, a plasma membrane-microfilament linker, signals cell survival through the phosphatidylinositol 3-kinase/Akt pathway". Proc. Natl. Acad. Sci. U.S.A. (UNITED STATES) 96 (13): 7300–5. doi:10.1073/pnas.96.13.7300. ISSN 0027-8424. PMC 22080. PMID 10377409. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=22080.

[1]

[2]

[3]

[4]

[5]

[6]

[7]

[8]

[9]

[10]

[11]

[12]

[13]

[14]

[15]

[16]

[17]

[18]

[19]

Ezrin

[edit] Interactions

[edit] References

[edit] Further reading

Personal tools

Namespaces

Variants

Views

Actions

Search

Navigation

Interaction

Toolbox

Print/export