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Coagulation factor II (thrombin) receptor-like 2
Symbols F2RL2 ; PAR-3; PAR3
External IDs OMIM601919 MGI1298208 HomoloGene36151 IUPHAR: 349 ChEMBL: 5477 GeneCards: F2RL2 Gene
RNA expression pattern
PBB GE F2RL2 206795 at tn.png
More reference expression data
Species Human Mouse
Entrez 2151 14064
Ensembl ENSG00000164220 ENSMUSG00000021675
UniProt O00254 O08675
RefSeq (mRNA) NM_001256566 NM_010170
RefSeq (protein) NP_001243495 NP_034300
Location (UCSC) Chr 5:
75.91 – 75.92 Mb
Chr 13:
95.7 – 95.7 Mb
PubMed search [1] [2]

Protease activated receptor 3 (PAR-3) also known as coagulation factor II receptor-like 2 (F2RL2) and thrombin receptor-like 2, is a protein that in humans is encoded by the F2RL2 gene.


Coagulation factor II (thrombin) receptor-like 2 (F2RL2) is a member of the large family of 7-transmembrane receptors that couple to G proteins. F2RL2 is also a member of the protease-activated receptor family and activated by thrombin. F2RL2 is activated by proteolytic cleavage of its extracellular amino terminus. The new amino terminus functions as a tethered ligand and activates the receptor. F2RL2 is a cofactor for F2RL3 activation by thrombin. It mediates thrombin-triggered phosphoinositide hydrolysis and is expressed in a variety of tissues.[1]

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This article incorporates text from the United States National Library of Medicine, which is in the public domain.