F2RL2

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Coagulation factor II (thrombin) receptor-like 2
Identifiers
Symbols F2RL2 ; PAR-3; PAR3
External IDs OMIM601919 MGI1298208 HomoloGene36151 IUPHAR: 349 ChEMBL: 5477 GeneCards: F2RL2 Gene
RNA expression pattern
PBB GE F2RL2 206795 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 2151 14064
Ensembl ENSG00000164220 ENSMUSG00000021675
UniProt O00254 O08675
RefSeq (mRNA) NM_001256566 NM_010170
RefSeq (protein) NP_001243495 NP_034300
Location (UCSC) Chr 5:
75.91 – 75.92 Mb
Chr 13:
95.7 – 95.7 Mb
PubMed search [1] [2]

Protease activated receptor 3 (PAR-3) also known as coagulation factor II receptor-like 2 (F2RL2) and thrombin receptor-like 2, is a protein that in humans is encoded by the F2RL2 gene.

Function[edit]

Coagulation factor II (thrombin) receptor-like 2 (F2RL2) is a member of the large family of 7-transmembrane receptors that couple to G proteins. F2RL2 is also a member of the protease-activated receptor family and activated by thrombin. F2RL2 is activated by proteolytic cleavage of its extracellular amino terminus. The new amino terminus functions as a tethered ligand and activates the receptor. F2RL2 is a cofactor for F2RL3 activation by thrombin. It mediates thrombin-triggered phosphoinositide hydrolysis and is expressed in a variety of tissues.[1]

See also[edit]

References[edit]

Further reading[edit]

  • Hollenberg MD, Compton SJ (2002). "International Union of Pharmacology. XXVIII. Proteinase-activated receptors.". Pharmacol. Rev. 54 (2): 203–17. doi:10.1124/pr.54.2.203. PMID 12037136. 
  • Ishihara H, Connolly AJ, Zeng D et al. (1997). "Protease-activated receptor 3 is a second thrombin receptor in humans.". Nature 386 (6624): 502–6. doi:10.1038/386502a0. PMID 9087410. 
  • Schmidt VA, Nierman WC, Maglott DR et al. (1998). "The human proteinase-activated receptor-3 (PAR-3) gene. Identification within a Par gene cluster and characterization in vascular endothelial cells and platelets.". J. Biol. Chem. 273 (24): 15061–8. doi:10.1074/jbc.273.24.15061. PMID 9614115. 
  • Xu WF, Andersen H, Whitmore TE et al. (1998). "Cloning and characterization of human protease-activated receptor 4". Proc. Natl. Acad. Sci. U.S.A. 95 (12): 6642–6. doi:10.1073/pnas.95.12.6642. PMC 22580. PMID 9618465. 
  • Guyonnet Dupérat V, Jacquelin B, Boisseau P et al. (1998). "Protease-activated receptor genes are clustered on 5q13". Blood 92 (1): 25–31. PMID 9639495. 
  • Kahn ML, Zheng YW, Huang W et al. (1998). "A dual thrombin receptor system for platelet activation". Nature 394 (6694): 690–4. doi:10.1038/29325. PMID 9716134. 
  • Kahn ML, Hammes SR, Botka C, Coughlin SR (1998). "Gene and locus structure and chromosomal localization of the protease-activated receptor gene family". J. Biol. Chem. 273 (36): 23290–6. doi:10.1074/jbc.273.36.23290. PMID 9722561. 
  • Kahn ML, Nakanishi-Matsui M, Shapiro MJ et al. (1999). "Protease-activated receptors 1 and 4 mediate activation of human platelets by thrombin". J. Clin. Invest. 103 (6): 879–87. doi:10.1172/JCI6042. PMC 408153. PMID 10079109. 
  • Hauck RW, Schulz C, Schömig A et al. (1999). "alpha-Thrombin stimulates contraction of human bronchial rings by activation of protease-activated receptors". Am. J. Physiol. 277 (1 Pt 1): L22–9. PMID 10409227. 
  • Nakanishi-Matsui M, Zheng YW, Sulciner DJ et al. (2000). "PAR3 is a cofactor for PAR4 activation by thrombin". Nature 404 (6778): 609–13. doi:10.1038/35007085. PMID 10766244. 
  • O'Brien PJ, Prevost N, Molino M et al. (2000). "Thrombin responses in human endothelial cells. Contributions from receptors other than PAR1 include the transactivation of PAR2 by thrombin-cleaved PAR1". J. Biol. Chem. 275 (18): 13502–9. doi:10.1074/jbc.275.18.13502. PMID 10788464. 
  • Cumashi A, Ansuini H, Celli N et al. (2001). "Neutrophil proteases can inactivate human PAR3 and abolish the co-receptor function of PAR3 on murine platelets". Thromb. Haemost. 85 (3): 533–8. PMID 11307827. 
  • Sambrano GR, Weiss EJ, Zheng YW et al. (2001). "Role of thrombin signalling in platelets in haemostasis and thrombosis". Nature 413 (6851): 74–8. doi:10.1038/35092573. PMID 11544528. 
  • Miike S, McWilliam AS, Kita H (2002). "Trypsin induces activation and inflammatory mediator release from human eosinophils through protease-activated receptor-2". J. Immunol. 167 (11): 6615–22. doi:10.4049/jimmunol.167.11.6615. PMID 11714832. 
  • Strausberg RL, Feingold EA, Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. 
  • Even-Ram SC, Grisaru-Granovsky S, Pruss D et al. (2003). "The pattern of expression of protease-activated receptors (PARs) during early trophoblast development". J. Pathol. 200 (1): 47–52. doi:10.1002/path.1338. PMID 12692840. 
  • Owen WG (2003). "PAR-3 is a low-affinity substrate, high affinity effector of thrombin". Biochem. Biophys. Res. Commun. 305 (1): 166–8. doi:10.1016/S0006-291X(03)00732-0. PMID 12732212. 
  • Tanaka N, Morita T, Nezu A et al. (2003). "Thrombin-induced Ca2+ mobilization in human gingival fibroblasts is mediated by protease-activated receptor-1 (PAR-1)". Life Sci. 73 (3): 301–10. doi:10.1016/S0024-3205(03)00269-8. PMID 12757837. 

This article incorporates text from the United States National Library of Medicine, which is in the public domain.