F2RL2

From Wikipedia, the free encyclopedia
Jump to: navigation, search
Coagulation factor II (thrombin) receptor-like 2
Identifiers
Symbols F2RL2 ; PAR-3; PAR3
External IDs OMIM601919 MGI1298208 HomoloGene36151 IUPHAR: PAR3 ChEMBL: 5477 GeneCards: F2RL2 Gene
RNA expression pattern
PBB GE F2RL2 206795 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 2151 14064
Ensembl ENSG00000164220 ENSMUSG00000021675
UniProt O00254 O08675
RefSeq (mRNA) NM_001256566 NM_010170
RefSeq (protein) NP_001243495 NP_034300
Location (UCSC) Chr 5:
75.91 – 75.92 Mb
Chr 13:
95.7 – 95.7 Mb
PubMed search [1] [2]

Protease activated receptor 3 (PAR-3) also known as coagulation factor II receptor-like 2 (F2RL2) and thrombin receptor-like 2, is a protein that in humans is encoded by the F2RL2 gene.

Function[edit]

Coagulation factor II (thrombin) receptor-like 2 (F2RL2) is a member of the large family of 7-transmembrane receptors that couple to G proteins. F2RL2 is also a member of the protease-activated receptor family and activated by thrombin. F2RL2 is activated by proteolytic cleavage of its extracellular amino terminus. The new amino terminus functions as a tethered ligand and activates the receptor. F2RL2 is a cofactor for F2RL3 activation by thrombin. It mediates thrombin-triggered phosphoinositide hydrolysis and is expressed in a variety of tissues.[1]

See also[edit]

References[edit]

Further reading[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.