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Coagulation factor II (thrombin) receptor-like 3
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols F2RL3 ; PAR4
External IDs OMIM602779 MGI1298207 HomoloGene36148 IUPHAR: 350 ChEMBL: 4691 GeneCards: F2RL3 Gene
RNA expression pattern
PBB GE F2RL3 207221 at tn.png
More reference expression data
Species Human Mouse
Entrez 9002 14065
Ensembl ENSG00000127533 ENSMUSG00000050147
UniProt Q96RI0 O88634
RefSeq (mRNA) NM_003950 NM_007975
RefSeq (protein) NP_003941 NP_032001
Location (UCSC) Chr 19:
17 – 17 Mb
Chr 8:
72.76 – 72.76 Mb
PubMed search [1] [2]

Protease-activated receptor 4 (PAR-4), also known as coagulation factor II (thrombin) receptor-like 3, is a protein that in humans is encoded by the F2RL3 gene.[1]


Coagulation factor II (thrombin) receptor-like 3 (F2RL3) is a member of the large family of 7-transmembrane-region receptors that couple to guanosine-nucleotide-binding proteins. F2RL3 is also a member of the protease-activated receptor family. F2RL3 is activated by proteolytic cleavage of its extracellular amino terminus. The new amino terminus functions as a tethered ligand and activates the receptor. F2RL3 is activated by thrombin and trypsin.[1]

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Further reading[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.