F2RL3

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Coagulation factor II (thrombin) receptor-like 3
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols F2RL3 ; PAR4
External IDs OMIM602779 MGI1298207 HomoloGene36148 IUPHAR: PAR4 ChEMBL: 4691 GeneCards: F2RL3 Gene
RNA expression pattern
PBB GE F2RL3 207221 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 9002 14065
Ensembl ENSG00000127533 ENSMUSG00000050147
UniProt Q96RI0 O88634
RefSeq (mRNA) NM_003950 NM_007975
RefSeq (protein) NP_003941 NP_032001
Location (UCSC) Chr 19:
17 – 17 Mb
Chr 8:
72.76 – 72.76 Mb
PubMed search [1] [2]

Protease-activated receptor 4 (PAR-4), also known as coagulation factor II (thrombin) receptor-like 3, is a protein that in humans is encoded by the F2RL3 gene.[1]

Function[edit]

Coagulation factor II (thrombin) receptor-like 3 (F2RL3) is a member of the large family of 7-transmembrane-region receptors that couple to guanosine-nucleotide-binding proteins. F2RL3 is also a member of the protease-activated receptor family. F2RL3 is activated by proteolytic cleavage of its extracellular amino terminus. The new amino terminus functions as a tethered ligand and activates the receptor. F2RL3 is activated by thrombin and trypsin.[1]

See also[edit]

References[edit]

Further reading[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.