Fatty acid-binding protein

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The fatty-acid-binding proteins (FABPs) are a family of transport proteins for fatty acids and other lipophilic substances such as eicosanoids and retinoids.[1][2] These proteins are thought to facilitate the transfer of fatty acids between extra- and intracellular membranes.[3] Some family members are also believed to transport lipophilic molecules from outer cell membrane to certain intracellular receptors such as PPAR.[4] Levels of fatty-acid-binding protein have been shown to decline with ageing in the mouse brain, possibly contributing to age-associated decline in synaptic activity.[5]

Family members[edit]

Members of this family include:

Protein name Gene Tissue distribution Comment
FABP 1 FABP1 liver
FABP 2 FABP2 intestinal
FABP 3 FABP3 muscle and heart mammary-derived growth inhibitor
FABP 4 FABP4 adipocyte
FABP 5 FABP5 epidermal psoriasis-associated
FABP 6 FABP6 ileal gastrotropin
FABP 7 FABP7 brain
FABP 8 PMP2 peripheral nervous system peripheral myelin protein 2
FABP 9 FABP9
FABP 11 fabp11 restricted to fishes
FABP 12 FABP12 presence shown in human retinoblastoma cell lines, rodent retina and testis.[6]
FABP 5-like 1 FABP5L1
FABP 5-like 2 FABP5L2
FABP 5-like 3 FABP5L3
FABP 5-like 4 FABP5L4
FABP 5-like 5 FABP5L5
FABP 5-like 6 FABP5L6
FABP 5-like 7 FABP5L7

References[edit]

  1. ^ Chmurzyńska A (2006). "The multigene family of fatty acid-binding proteins (FABPs): function, structure and polymorphism". Journal of Applied Genetics 47 (1): 39–48. doi:10.1007/BF03194597. PMID 16424607. 
  2. ^ Smathers RL, Petersen DR (Mar 2011). "The human fatty acid-binding protein family: evolutionary divergences and functions". Human Genomics 5 (3): 170–191. doi:10.1186/1479-7364-5-3-170. PMC 3500171. PMID 21504868. 
  3. ^ Weisiger RA (Oct 2002). "Cytosolic fatty acid binding proteins catalyze two distinct steps in intracellular transport of their ligands". Molecular and Cellular Biochemistry 239 (1-2): 35–43. doi:10.1023/A:1020550405578. PMID 12479566. 
  4. ^ Tan NS, Shaw NS, Vinckenbosch N, Liu P, Yasmin R, Desvergne B et al. (Jul 2002). "Selective cooperation between fatty acid binding proteins and peroxisome proliferator-activated receptors in regulating transcription". Molecular and Cellular Biology 22 (14): 5114–27. doi:10.1128/MCB.22.14.5114-5127.2002. PMC 139777. PMID 12077340. 
  5. ^ Pu L, Igbavboa U, Wood WG, Roths JB, Kier AB, Spener F et al. (Aug 1999). "Expression of fatty acid binding proteins is altered in aged mouse brain". Molecular and Cellular Biochemistry 198 (1-2): 69–78. doi:10.1023/A:1006946027619. PMID 10497880. 
  6. ^ Liu RZ, Li X, Godbout R (Dec 2008). "A novel fatty acid-binding protein (FABP) gene resulting from tandem gene duplication in mammals: transcription in rat retina and testis". Genomics 92 (6). doi:10.1016/j.ygeno.2008.08.003. PMID 18786628. 

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