FABP1

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Fatty acid binding protein 1, liver
Protein FABP1 PDB 2f73.png
PDB rendering based on 2f73.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols FABP1 ; FABPL; L-FABP
External IDs OMIM134650 MGI95479 HomoloGene1106 ChEMBL: 5421 GeneCards: FABP1 Gene
RNA expression pattern
PBB GE FABP1 205892 s at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 2168 14080
Ensembl ENSG00000163586 ENSMUSG00000054422
UniProt P07148 P12710
RefSeq (mRNA) NM_001443 NM_017399
RefSeq (protein) NP_001434 NP_059095
Location (UCSC) Chr 2:
88.42 – 88.43 Mb
Chr 6:
71.2 – 71.21 Mb
PubMed search [1] [2]

Fatty acid-binding protein 1 (FABP1) also known as liver-type fatty acid-binding protein (L-FABP) is a protein that in humans is encoded by the FABP1 gene.[1][2][3]

Function[edit]

FABP1 encodes the fatty acid-binding protein found in liver. Fatty acid binding proteins are a family of small, highly conserved, cytoplasmic proteins that bind long-chain fatty acids and other hydrophobic ligands. FABP1 and FABP6 (the ileal fatty acid binding protein) are also able to bind bile acids. It is thought that FABPs roles include fatty acid uptake, transport, and metabolism.[3]

References[edit]

  1. ^ Chen SH, Van Tuinen P, Ledbetter DH, Smith LC, Chan L (Jul 1986). "Human liver fatty acid binding protein gene is located on chromosome 2". Somat Cell Mol Genet 12 (3): 303–6. doi:10.1007/BF01570790. PMID 3012800. 
  2. ^ Weickert MO, Loeffelholz CV, Roden M, Chandramouli V, Brehm A, Nowotny P, Osterhoff MA, Isken F, Spranger J, Landau BR, Pfeiffer AF, Mohlig M (Oct 2007). "A Thr94Ala mutation in human liver fatty acid-binding protein contributes to reduced hepatic glycogenolysis and blunted elevation of plasma glucose levels in lipid-exposed subjects". Am J Physiol Endocrinol Metab 293 (4): E1078–84. doi:10.1152/ajpendo.00337.2007. PMID 17698986. 
  3. ^ a b "Entrez Gene: FABP1 fatty acid binding protein 1, liver". 

Further reading[edit]