FABP1

Fatty acid binding protein 1, liver
PDB rendering based on 2f73.
Available structures PDB 2F73, 2PY1
Identifiers
Symbols	FABP1; FABPL; L-FABP
External IDs	OMIM: 134650 MGI: 95479 HomoloGene: 1106 GeneCards: FABP1 Gene
Gene Ontology Molecular function • chromatin binding • transporter activity • long-chain fatty acid transporter activity • fatty acid binding • phospholipid binding • drug binding • bile acid binding Cellular component • nucleus • cytoplasm • peroxisomal matrix • cytosol • apical cortex Biological process • positive regulation of cell proliferation • organ morphogenesis • positive regulation of fatty acid beta-oxidation • intestinal absorption • positive regulation of hydrolase activity Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	2168	14080
Ensembl	ENSG00000163586	ENSMUSG00000054422
UniProt	P07148	Q3V2F7
RefSeq (mRNA)	NM_001443	NM_017399.4
RefSeq (protein)	NP_001434	NP_059095.1
Location (UCSC)	Chr 2: 88.42 – 88.43 Mb	Chr 6: 71.15 – 71.16 Mb
PubMed search	[1]	[2]

Fatty acid-binding protein 1 (FABP1) also known as liver-type fatty acid-binding protein (L-FABP) is a protein that in humans is encoded by the FABP1 gene.

Function

FABP1 encodes the fatty acid-binding protein found in liver. Fatty acid binding proteins are a family of small, highly conserved, cytoplasmic proteins that bind long-chain fatty acids and other hydrophobic ligands. FABP1 and FABP6 (the ileal fatty acid binding protein) are also able to bind bile acids. It is thought that FABPs roles include fatty acid uptake, transport, and metabolism.

Further reading

• Glatz JF, Börchers T, Spener F, van der Vusse GJ (1995). "Fatty acids in cell signalling: modulation by lipid binding proteins.". Prostaglandins Leukot. Essent. Fatty Acids 52 (2–3): 121–7. doi:10.1016/0952-3278(95)90010-1. PMID 7784447. 
• Kaikaus RM, Chan WK, Ortiz de Montellano PR, Bass NM (1993). "Mechanisms of regulation of liver fatty acid-binding protein". Mol. Cell. Biochem. 123 (1–2): 93–100. doi:10.1007/BF01076479. PMID 8232272. 
• Londraville RL (1997). "Intracellular fatty acid-binding proteins: putting lower vertebrates in perspective". Braz. J. Med. Biol. Res. 29 (6): 707–20. PMID 9070383. 
• Börchers T, Hohoff C, Buhlmann C, Spener F (1997). "Heart-type fatty acid binding protein - involvement in growth inhibition and differentiation". Prostaglandins Leukot. Essent. Fatty Acids 57 (1): 77–84. doi:10.1016/S0952-3278(97)90496-8. PMID 9250612. 
• Carroll SL, Roth KA, Gordon JI (1990). "Liver fatty acid-binding protein: a marker for studying cellular differentiation in gut epithelial neoplasms". Gastroenterology 99 (6): 1727–35. PMID 1699834. 
• Sweetser DA, Birkenmeier EH, Klisak IJ, et al. (1987). "The human and rodent intestinal fatty acid binding protein genes. A comparative analysis of their structure, expression, and linkage relationships". J. Biol. Chem. 262 (33): 16060–71. PMID 2824476. 
• Chan L, Wei CF, Li WH, et al. (1985). "Human liver fatty acid binding protein cDNA and amino acid sequence. Functional and evolutionary implications". J. Biol. Chem. 260 (5): 2629–32. PMID 3838309. 
• Lowe JB, Boguski MS, Sweetser DA, et al. (1985). "Human liver fatty acid binding protein. Isolation of a full length cDNA and comparative sequence analyses of orthologous and paralogous proteins". J. Biol. Chem. 260 (6): 3413–7. PMID 3838313. 
• Murphy EJ (1998). "L-FABP and I-FABP expression increase NBD-stearate uptake and cytoplasmic diffusion in L cells". Am. J. Physiol. 275 (2 Pt 1): G244–9. PMID 9688651. 
• Wolfrum C, Börchers T, Sacchettini JC, Spener F (2000). "Binding of fatty acids and peroxisome proliferators to orthologous fatty acid binding proteins from human, murine, and bovine liver". Biochemistry 39 (6): 1469–74. doi:10.1021/bi991638u. PMID 10684629. 
• Wolfrum C, Borrmann CM, Borchers T, Spener F (2001). "Fatty acids and hypolipidemic drugs regulate peroxisome proliferator-activated receptors alpha - and gamma-mediated gene expression via liver fatty acid binding protein: a signaling path to the nucleus". Proc. Natl. Acad. Sci. U.S.A. 98 (5): 2323–8. doi:10.1073/pnas.051619898. PMC 30137. PMID 11226238. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=30137. 
• Schroeder F, Atshaves BP, Starodub O, et al. (2001). "Expression of liver fatty acid binding protein alters growth and differentiation of embryonic stem cells". Mol. Cell. Biochem. 219 (1–2): 127–38. doi:10.1023/A:1010851130136. PMID 11354243. 
• Zimmerman AW, van Moerkerk HT, Veerkamp JH (2001). "Ligand specificity and conformational stability of human fatty acid-binding proteins". Int. J. Biochem. Cell Biol. 33 (9): 865–76. doi:10.1016/S1357-2725(01)00070-X. PMID 11461829. 
• Mésange F, Sebbar M, Capdevielle J, et al. (2003). "Identification of two tamoxifen target proteins by photolabeling with 4-(2-morpholinoethoxy)benzophenone". Bioconjug. Chem. 13 (4): 766–72. doi:10.1021/bc015588t. PMID 12121132. 
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241.