FABP2

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Fatty acid binding protein 2, intestinal
Protein FABP2 PDB 1kzw.png
PDB rendering based on 1kzw.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols FABP2 ; FABPI; I-FABP
External IDs OMIM134640 MGI95478 HomoloGene107 ChEMBL: 4879 GeneCards: FABP2 Gene
RNA expression pattern
PBB GE FABP2 207475 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 2169 14079
Ensembl ENSG00000145384 ENSMUSG00000023057
UniProt P12104 P55050
RefSeq (mRNA) NM_000134 NM_007980
RefSeq (protein) NP_000125 NP_032006
Location (UCSC) Chr 4:
120.24 – 120.24 Mb
Chr 3:
122.9 – 122.9 Mb
PubMed search [1] [2]

Fatty acid-binding protein 2 (FABP2) also known as Intestinal-type fatty acid-binding protein (I-FABP) is a protein that in humans is encoded by the FABP2 gene.[1]

Function[edit]

The intracellular fatty acid-binding proteins (FABPs) belong to a multigene family with nearly twenty identified members. FABPs are divided into at least three distinct types, namely the hepatic-, intestinal- and cardiac-type. They form 14-15 kDa proteins and are thought to participate in the uptake, intracellular metabolism and/or transport of long-chain fatty acids. They may also be responsible in the modulation of cell growth and proliferation. Intestinal fatty acid-binding protein 2 gene contains four exons and is an abundant cytosolic protein in small intestine epithelial cells.[1]

Clinical significance[edit]

This gene has a polymorphism at codon 54 that identified an alanine-encoding allele and a threonine-encoding allele. Thr-54 protein is associated with increased fat oxidation and insulin resistance.[1]

References[edit]

Further reading[edit]