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FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived)
Available structures
PDB Ortholog search: PDBe, RCSB
External IDs OMIM602654 MGI2446173 HomoloGene38098 GeneCards: FARP1 Gene
RNA expression pattern
PBB GE FARP1 201910 at tn.png
More reference expression data
Species Human Mouse
Entrez 10160 223254
Ensembl ENSG00000152767 ENSMUSG00000025555
UniProt Q9Y4F1 F8VPU2
RefSeq (mRNA) NM_001001715 NM_134082
RefSeq (protein) NP_001001715 NP_598843
Location (UCSC) Chr 13:
98.79 – 99.1 Mb
Chr 14:
121.04 – 121.28 Mb
PubMed search [1] [2]

FERM, RhoGEF and pleckstrin domain-containing protein 1 is a protein that in humans is encoded by the FARP1 gene.[1][2]

This gene was originally isolated through subtractive hybridization due to its increased expression in differentiated chondrocytes versus dedifferentiated chondrocytes. The resulting protein contains a predicted ezrin-like domain, a Dbl homology domain, and a pleckstrin homology domain. It is believed to be a member of the band 4.1 superfamily whose members link the cytoskeleton to the cell membrane. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.[2]


  1. ^ Koyano Y, Kawamoto T, Shen M, Yan W, Noshiro M, Fujii K, Kato Y (Jan 1998). "Molecular cloning and characterization of CDEP, a novel human protein containing the ezrin-like domain of the band 4.1 superfamily and the Dbl homology domain of Rho guanine nucleotide exchange factors". Biochem Biophys Res Commun 241 (2): 369–75. doi:10.1006/bbrc.1997.7826. PMID 9425278. 
  2. ^ a b "Entrez Gene: FARP1 FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived)". 

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