FARP1

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FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived)
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols FARP1 ; CDEP; FARP1-IT1; PLEKHC2; PPP1R75
External IDs OMIM602654 MGI2446173 HomoloGene38098 GeneCards: FARP1 Gene
RNA expression pattern
PBB GE FARP1 201910 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 10160 223254
Ensembl ENSG00000152767 ENSMUSG00000025555
UniProt Q9Y4F1 F8VPU2
RefSeq (mRNA) NM_001001715 NM_134082
RefSeq (protein) NP_001001715 NP_598843
Location (UCSC) Chr 13:
98.79 – 99.1 Mb
Chr 14:
121.04 – 121.28 Mb
PubMed search [1] [2]

FERM, RhoGEF and pleckstrin domain-containing protein 1 is a protein that in humans is encoded by the FARP1 gene.[1][2]

This gene was originally isolated through subtractive hybridization due to its increased expression in differentiated chondrocytes versus dedifferentiated chondrocytes. The resulting protein contains a predicted ezrin-like domain, a Dbl homology domain, and a pleckstrin homology domain. It is believed to be a member of the band 4.1 superfamily whose members link the cytoskeleton to the cell membrane. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.[2]

References[edit]

  1. ^ Koyano Y, Kawamoto T, Shen M, Yan W, Noshiro M, Fujii K, Kato Y (Jan 1998). "Molecular cloning and characterization of CDEP, a novel human protein containing the ezrin-like domain of the band 4.1 superfamily and the Dbl homology domain of Rho guanine nucleotide exchange factors". Biochem Biophys Res Commun 241 (2): 369–75. doi:10.1006/bbrc.1997.7826. PMID 9425278. 
  2. ^ a b "Entrez Gene: FARP1 FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived)". 

Further reading[edit]

External links[edit]