FAT (gene)

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FAT tumor suppressor homolog 1 (Drosophila)
Identifiers
Symbols FAT1 ; CDHF7; CDHR8; FAT; ME5; hFat1
External IDs OMIM600976 MGI109168 HomoloGene66302 GeneCards: FAT1 Gene
RNA expression pattern
PBB GE FAT 201579 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 2195 14107
Ensembl ENSG00000083857 ENSMUSG00000070047
UniProt Q14517 A7ISQ0
RefSeq (mRNA) NM_005245 NM_001081286
RefSeq (protein) NP_005236 NP_001074755
Location (UCSC) Chr 4:
187.51 – 187.65 Mb
Chr 8:
44.95 – 45.05 Mb
PubMed search [1] [2]

Protocadherin Fat 1 is a protein that in humans is encoded by the FAT1 gene.[1][2]

This gene is an ortholog of the Drosophila fat gene, which encodes a tumor suppressor essential for controlling cell proliferation during Drosophila development. The gene product is a member of the cadherin superfamily, a group of integral membrane proteins characterized by the presence of cadherin-type repeats. In addition to containing 34 tandem cadherin-type repeats, the gene product has five epidermal growth factor (EGF)-like repeats and one laminin A-G domain. This gene is expressed at high levels in a number of fetal epithelia. Its product probably functions as an adhesion molecule and/or signaling receptor, and is likely to be important in developmental processes and cell communication. Transcript variants derived from alternative splicing and/or alternative promoter usage exist, but they have not been fully described.[2]

References[edit]

  1. ^ Dunne J, Hanby AM, Poulsom R, Jones TA, Sheer D, Chin WG, Da SM, Zhao Q, Beverley PC, Owen MJ (Mar 1996). "Molecular cloning and tissue expression of FAT, the human homologue of the Drosophila fat gene that is located on chromosome 4q34-q35 and encodes a putative adhesion molecule". Genomics 30 (2): 207–23. doi:10.1006/geno.1995.9884. PMID 8586420. 
  2. ^ a b "Entrez Gene: FAT FAT tumor suppressor homolog 1 (Drosophila)". 

Further reading[edit]