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F-box and leucine-rich repeat protein 3
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols FBXL3 ; FBL3; FBL3A; FBXL3A
External IDs OMIM605653 HomoloGene8127 GeneCards: FBXL3 Gene
Species Human Mouse
Entrez 26224 50789
Ensembl ENSG00000005812 ENSMUSG00000022124
UniProt Q9UKT7 Q8C4V4
RefSeq (mRNA) NM_012158 NM_015822
RefSeq (protein) NP_036290 NP_056637
Location (UCSC) Chr 13:
77.57 – 77.6 Mb
Chr 14:
103.08 – 103.1 Mb
PubMed search [1] [2]

F-box/LRR-repeat protein 3 is a protein that in humans is encoded by the FBXL3 gene.[1][2]

This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD40 repeats, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbls class and, in addition to an F-box, contains several tandem leucine-rich repeats and is localized in the nucleus.[3]


FBXL3 has been shown to interact with SKP1A.[4]


  1. ^ Cenciarelli C, Chiaur DS, Guardavaccaro D, Parks W, Vidal M, Pagano M (Dec 1999). "Identification of a family of human F-box proteins". Curr Biol 9 (20): 1177–9. doi:10.1016/S0960-9822(00)80020-2. PMID 10531035. 
  2. ^ Chiaur DS, Murthy S, Cenciarelli C, Parks W, Loda M, Inghirami G, Demetrick D, Pagano M (Jun 2000). "Five human genes encoding F-box proteins: chromosome mapping and analysis in human tumors". Cytogenet Cell Genet 88 (3–4): 255–8. doi:10.1159/000015532. PMID 10828603. 
  3. ^ "Entrez Gene: FBXL3 F-box and leucine-rich repeat protein 3". 
  4. ^ Cenciarelli, C; Chiaur D S; Guardavaccaro D; Parks W; Vidal M; Pagano M (Oct 1999). "Identification of a family of human F-box proteins". Curr. Biol. (ENGLAND) 9 (20): 1177–9. doi:10.1016/S0960-9822(00)80020-2. ISSN 0960-9822. PMID 10531035. 

Further reading[edit]