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F-box and leucine-rich repeat protein 5
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols FBXL5 ; FBL4; FBL5; FLR1
External IDs OMIM605655 MGI2152883 HomoloGene8129 GeneCards: FBXL5 Gene
RNA expression pattern
PBB GE FBXL5 209004 s at tn.png
PBB GE FBXL5 209005 at tn.png
More reference expression data
Species Human Mouse
Entrez 26234 242960
Ensembl ENSG00000118564 ENSMUSG00000039753
UniProt Q9UKA1 Q8C2S5
RefSeq (mRNA) NM_001193534 NM_001159963
RefSeq (protein) NP_001180463 NP_001153435
Location (UCSC) Chr 4:
15.61 – 15.68 Mb
Chr 5:
43.74 – 43.82 Mb
PubMed search [1] [2]

F-box/LRR-repeat protein 5 is a protein that in humans is encoded by the FBXL5 gene.[1][2]

This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbls class and, in addition to an F-box, contains several tandem leucine-rich repeats. Alternative splicing of this gene generates 2 transcript variants.[2]

FBXL5 is an iron sensor. It promotes IRP2 ubiquitination and then its degradation.


  1. ^ Cenciarelli C, Chiaur DS, Guardavaccaro D, Parks W, Vidal M, Pagano M (Dec 1999). "Identification of a family of human F-box proteins". Curr Biol 9 (20): 1177–9. doi:10.1016/S0960-9822(00)80020-2. PMID 10531035. 
  2. ^ a b "Entrez Gene: FBXL5 F-box and leucine-rich repeat protein 5". 

Further reading[edit]