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F-box protein 7
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols FBXO7 ; FBX; FBX07; FBX7; PARK15; PKPS
External IDs OMIM605648 MGI1917004 HomoloGene8136 GeneCards: FBXO7 Gene
RNA expression pattern
PBB GE FBXO7 201178 at tn.png
More reference expression data
Species Human Mouse
Entrez 25793 69754
Ensembl ENSG00000100225 ENSMUSG00000001786
UniProt Q9Y3I1 Q3U7U3
RefSeq (mRNA) NM_001033024 NM_153195
RefSeq (protein) NP_001028196 NP_694875
Location (UCSC) Chr 22:
32.87 – 32.89 Mb
Chr 10:
86.02 – 86.05 Mb
PubMed search [1] [2]

F-box only protein 7 is a protein that in humans is encoded by the FBXO7 gene.[1][2][3][4]


This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class and it may play a role in regulation of hematopoiesis. Alternatively spliced transcript variants of this gene have been identified with the full-length natures of only some variants being determined.[4]


FBXO7 has been shown to interact with SKP1A[5] and CUL1.[1][6]


  1. ^ a b Cenciarelli C, Chiaur DS, Guardavaccaro D, Parks W, Vidal M, Pagano M (December 1999). "Identification of a family of human F-box proteins". Curr Biol 9 (20): 1177–9. doi:10.1016/S0960-9822(00)80020-2. PMID 10531035. 
  2. ^ Winston JT, Koepp DM, Zhu C, Elledge SJ, Harper JW (December 1999). "A family of mammalian F-box proteins". Curr Biol 9 (20): 1180–2. doi:10.1016/S0960-9822(00)80021-4. PMID 10531037. 
  3. ^ Di Fonzo A, Dekker MC, Montagna P, Baruzzi A, Yonova EH, Correia Guedes L et al. (January 2009). "FBXO7 mutations cause autosomal recessive, early-onset parkinsonian-pyramidal syndrome". Neurology 72 (3): 240–5. doi:10.1212/01.wnl.0000338144.10967.2b. PMID 19038853. 
  4. ^ a b "Entrez Gene: FBXO7 F-box protein 7". 
  5. ^ Cenciarelli C, Chiaur DS, Guardavaccaro D, Parks W, Vidal M, Pagano M (October 1999). "Identification of a family of human F-box proteins". Curr. Biol. 9 (20): 1177–9. doi:10.1016/S0960-9822(00)80020-2. PMID 10531035. 
  6. ^ Kirk R, Laman H, Knowles PP, Murray-Rust J, Lomonosov M, Meziane el K et al. (August 2008). "Structure of a conserved dimerization domain within the F-box protein Fbxo7 and the PI31 proteasome inhibitor". J. Biol. Chem. 283 (32): 22325–35. doi:10.1074/jbc.M709900200. PMID 18495667. 

Further reading[edit]