FBXO7

From Wikipedia, the free encyclopedia
Jump to: navigation, search
F-box protein 7
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols FBXO7 ; FBX; FBX07; FBX7; PARK15; PKPS
External IDs OMIM605648 MGI1917004 HomoloGene8136 GeneCards: FBXO7 Gene
RNA expression pattern
PBB GE FBXO7 201178 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 25793 69754
Ensembl ENSG00000100225 ENSMUSG00000001786
UniProt Q9Y3I1 Q3U7U3
RefSeq (mRNA) NM_001033024 NM_153195
RefSeq (protein) NP_001028196 NP_694875
Location (UCSC) Chr 22:
32.87 – 32.89 Mb
Chr 10:
86.02 – 86.05 Mb
PubMed search [1] [2]

F-box only protein 7 is a protein that in humans is encoded by the FBXO7 gene.[1][2][3][4]

Function[edit]

This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class and it may play a role in regulation of hematopoiesis. Alternatively spliced transcript variants of this gene have been identified with the full-length natures of only some variants being determined.[4]

Interactions[edit]

FBXO7 has been shown to interact with SKP1A[5] and CUL1.[1][6]

References[edit]

  1. ^ a b Cenciarelli C, Chiaur DS, Guardavaccaro D, Parks W, Vidal M, Pagano M (December 1999). "Identification of a family of human F-box proteins". Curr Biol 9 (20): 1177–9. doi:10.1016/S0960-9822(00)80020-2. PMID 10531035. 
  2. ^ Winston JT, Koepp DM, Zhu C, Elledge SJ, Harper JW (December 1999). "A family of mammalian F-box proteins". Curr Biol 9 (20): 1180–2. doi:10.1016/S0960-9822(00)80021-4. PMID 10531037. 
  3. ^ Di Fonzo A, Dekker MC, Montagna P, Baruzzi A, Yonova EH, Correia Guedes L et al. (January 2009). "FBXO7 mutations cause autosomal recessive, early-onset parkinsonian-pyramidal syndrome". Neurology 72 (3): 240–5. doi:10.1212/01.wnl.0000338144.10967.2b. PMID 19038853. 
  4. ^ a b "Entrez Gene: FBXO7 F-box protein 7". 
  5. ^ Cenciarelli C, Chiaur DS, Guardavaccaro D, Parks W, Vidal M, Pagano M (October 1999). "Identification of a family of human F-box proteins". Curr. Biol. 9 (20): 1177–9. doi:10.1016/S0960-9822(00)80020-2. PMID 10531035. 
  6. ^ Kirk R, Laman H, Knowles PP, Murray-Rust J, Lomonosov M, Meziane el K et al. (August 2008). "Structure of a conserved dimerization domain within the F-box protein Fbxo7 and the PI31 proteasome inhibitor". J. Biol. Chem. 283 (32): 22325–35. doi:10.1074/jbc.M709900200. PMID 18495667. 

Further reading[edit]