FBXW7

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F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase
Protein FBXW7 PDB 2ovp.png
PDB rendering based on 2ovp.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols FBXW7 ; AGO; CDC4; FBW6; FBW7; FBX30; FBXO30; FBXW6; SEL-10; SEL10; hAgo; hCdc4
External IDs OMIM606278 MGI1354695 HomoloGene117451 GeneCards: FBXW7 Gene
RNA expression pattern
PBB GE FBXW7 218751 s at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 55294 50754
Ensembl ENSG00000109670 ENSMUSG00000028086
UniProt Q969H0 Q8VBV4
RefSeq (mRNA) NM_001013415 NM_001177773
RefSeq (protein) NP_001013433 NP_001171244
Location (UCSC) Chr 4:
153.24 – 153.46 Mb
Chr 3:
84.82 – 84.98 Mb
PubMed search [1] [2]

F-box/WD repeat-containing protein 7 is a protein that in humans is encoded by the FBXW7 gene.[1][2][3]

This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene was previously referred to as FBX30, and belongs to the Fbws class; in addition to an F-box, this protein contains 7 tandem WD40 repeats. This protein binds directly to cyclin E and probably targets cyclin E for ubiquitin-mediated degradation. Mutations in this gene are detected in ovarian, breast and colorectal cancer cell lines, implicating the gene's potential role in the pathogenesis of human cancers. Three transcript variants encoding three different isoforms have been found for this gene.[3]

Interactions[edit]

FBXW7 has been shown to interact with PPARGC1A,[4] Parkin (ligase),[5] MYB[6] and SKP1A.[5][7]

References[edit]

  1. ^ Winston JT, Koepp DM, Zhu C, Elledge SJ, Harper JW (Dec 1999). "A family of mammalian F-box proteins". Curr Biol 9 (20): 1180–2. doi:10.1016/S0960-9822(00)80021-4. PMID 10531037. 
  2. ^ Gupta-Rossi N, Le Bail O, Gonen H, Brou C, Logeat F, Six E, Ciechanover A, Israel A (Sep 2001). "Functional interaction between SEL-10, an F-box protein, and the nuclear form of activated Notch1 receptor". J Biol Chem 276 (37): 34371–8. doi:10.1074/jbc.M101343200. PMID 11425854. 
  3. ^ a b "Entrez Gene: FBXW7 F-box and WD repeat domain containing 7". 
  4. ^ Olson, Brian L; Hock M Benjamin, Ekholm-Reed Susanna, Wohlschlegel James A, Dev Kumlesh K, Kralli Anastasia, Reed Steven I (Jan 2008). "SCFCdc4 acts antagonistically to the PGC-1α transcriptional coactivator by targeting it for ubiquitin-mediated proteolysis". Genes Dev. (United States) 22 (2): 252–64. doi:10.1101/gad.1624208. ISSN 0890-9369. PMC 2192758. PMID 18198341. 
  5. ^ a b Staropoli, John F; McDermott Caroline; Martinat Cécile; Schulman Brenda; Demireva Elena; Abeliovich Asa (Mar 2003). "Parkin is a component of an SCF-like ubiquitin ligase complex and protects postmitotic neurons from kainate excitotoxicity". Neuron (United States) 37 (5): 735–49. doi:10.1016/S0896-6273(03)00084-9. ISSN 0896-6273. PMID 12628165. 
  6. ^ Kanei-Ishii, Chie; Nomura Teruaki; Takagi Tsuyoshi; Watanabe Nobumoto; Nakayama Keiichi I; Ishii Shunsuke (Nov 2008). "Fbxw7 Acts as an E3 Ubiquitin Ligase That Targets c-Myb for Nemo-like Kinase (NLK)-induced Degradation". J. Biol. Chem. (United States) 283 (45): 30540–8. doi:10.1074/jbc.M804340200. ISSN 0021-9258. PMC 2662147. PMID 18765672. 
  7. ^ Wu, G; Lyapina S; Das I; Li J; Gurney M; Pauley A; Chui I; Deshaies R J; Kitajewski J (Nov 2001). "SEL-10 Is an Inhibitor of Notch Signaling That Targets Notch for Ubiquitin-Mediated Protein Degradation". Mol. Cell. Biol. (United States) 21 (21): 7403–15. doi:10.1128/MCB.21.21.7403-7415.2001. ISSN 0270-7306. PMC 99913. PMID 11585921. 

Further reading[edit]