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Fc fragment of IgG, low affinity IIIb, receptor (CD16b)
Protein FCGR3B PDB 1e4j.png
PDB rendering based on 1e4j.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols FCGR3B ; CD16; CD16b; FCG3; FCGR3; FCR-10; FCRIII; FCRIIIb
External IDs OMIM610665 HomoloGene477 ChEMBL: 5842 GeneCards: FCGR3B Gene
RNA expression pattern
PBB GE FCGR3B 204007 at tn.png
PBB GE FCGR3B 204006 s at tn.png
More reference expression data
Species Human Mouse
Entrez 2215 246256
Ensembl ENSG00000162747 ENSMUSG00000059089
UniProt O75015 n/a
RefSeq (mRNA) NM_000570 NM_144559
RefSeq (protein) NP_000561 NP_653142
Location (UCSC) Chr 1:
161.59 – 161.6 Mb
Chr 1:
171.02 – 171.03 Mb
PubMed search [1] [2]

FCGR3B (Fc fragment of IgG, low affinity IIIb, receptor), also known as CD16b (Cluster of Differentiation 16b), is a human gene.[1]

Clinical relevance[edit]

Mutations and copy-number variations in this gene have been associated to clinical cases of glomerulonephritis.[2]

See also[edit]


  1. ^ "Entrez Gene: FCGR3B Fc fragment of IgG, low affinity IIIb, receptor (CD16b)". 
  2. ^ Aitman, TJ; Dong, R, Vyse, TJ, Norsworthy, PJ, Johnson, MD, Smith, J, Mangion, J, Roberton-Lowe, C, Marshall, AJ, Petretto, E, Hodges, MD, Bhangal, G, Patel, SG, Sheehan-Rooney, K, Duda, M, Cook, PR, Evans, DJ, Domin, J, Flint, J, Boyle, JJ, Pusey, CD, Cook, HT (Feb 16, 2006). "Copy number polymorphism in Fcgr3 predisposes to glomerulonephritis in rats and humans.". Nature 439 (7078): 851–5. doi:10.1038/nature04489. PMID 16482158. 

Further reading[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.