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Ficolin (collagen/fibrinogen domain containing lectin) 2
Protein FCN2 PDB 2j0g.png
PDB rendering based on 2j0g.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols FCN2 ; EBP-37; FCNL; P35; ficolin-2
External IDs OMIM601624 HomoloGene3031 GeneCards: FCN2 Gene
RNA expression pattern
PBB GE FCN2 207804 s at tn.png
More reference expression data
Species Human Mouse
Entrez 2220 n/a
Ensembl ENSG00000160339 n/a
UniProt Q15485 n/a
RefSeq (mRNA) NM_004108 n/a
RefSeq (protein) NP_004099 n/a
Location (UCSC) Chr 9:
137.77 – 137.78 Mb
PubMed search [1] n/a

Ficolin-2, which was initially identified as L-ficolin, is a protein that in humans is encoded by the FCN2 gene. [1][2]

The product of this gene belongs to the ficolin family of proteins. This family is characterized by the presence of a leader peptide, a short N-terminal segment, followed by a collagen-like region, and a C-terminal fibrinogen-like domain. This gene is predominantly expressed in the liver, and has been shown to have carbohydrate binding and opsonic activities. Alternatively spliced transcript variants encoding different isoforms have been identified.[2]


  1. ^ Endo Y, Sato Y, Matsushita M, Fujita T (Feb 1997). "Cloning and characterization of the human lectin P35 gene and its related gene". Genomics 36 (3): 515–21. doi:10.1006/geno.1996.0497. PMID 8884275. 
  2. ^ a b "Entrez Gene: FCN2 ficolin (collagen/fibrinogen domain containing lectin) 2 (hucolin)". 

Further reading[edit]