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Fermitin family member 2
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols FERMT2 ; KIND2; MIG2; PLEKHC1; UNC112; UNC112B; mig-2
External IDs OMIM607746 MGI2385001 HomoloGene4976 GeneCards: FERMT2 Gene
RNA expression pattern
PBB GE PLEKHC1 209209 s at tn.png
PBB GE PLEKHC1 209210 s at tn.png
PBB GE PLEKHC1 214212 x at tn.png
More reference expression data
Species Human Mouse
Entrez 10979 218952
Ensembl ENSG00000073712 ENSMUSG00000037712
UniProt Q96AC1 Q8CIB5
RefSeq (mRNA) NM_001134999 NM_146054
RefSeq (protein) NP_001128471 NP_666166
Location (UCSC) Chr 14:
53.32 – 53.42 Mb
Chr 14:
45.46 – 45.53 Mb
PubMed search [1] [2]

Fermitin family homolog 2 (FERMT2) also known as pleckstrin homology domain-containing family C member 1 (PLEKHC1) is a protein that in humans is encoded by the FERMT2 gene.[1][2][3]


FERMT2 is a component of extracellular matrix structures in mammalian cells and is required for proper control of cell shape change.[4]


FERMT2 has been shown to interact with FBLIM1.[4]

External links[edit]


  1. ^ Wick M, Bürger C, Brüsselbach S, Lucibello FC, Müller R (January 1994). "Identification of serum-inducible genes: different patterns of gene regulation during G0-->S and G1-->S progression". J. Cell. Sci. 107 (1): 227–39. PMID 8175911. 
  2. ^ Weinstein EJ, Bourner M, Head R, Zakeri H, Bauer C, Mazzarella R (April 2003). "URP1: a member of a novel family of PH and FERM domain-containing membrane-associated proteins is significantly over-expressed in lung and colon carcinomas". Biochim. Biophys. Acta 1637 (3): 207–16. doi:10.1016/S0925-4439(03)00035-8. PMID 12697302. 
  3. ^ "Entrez Gene: FERMT2". 
  4. ^ a b Tu Y, Wu S, Shi X, Chen K, Wu C (April 2003). "Migfilin and Mig-2 link focal adhesions to filamin and the actin cytoskeleton and function in cell shape modulation". Cell 113 (1): 37–47. doi:10.1016/S0092-8674(03)00163-6. PMID 12679033. 

Further reading[edit]