FGF10

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Fibroblast growth factor 10
Protein FGF10 PDB 1nun.png
PDB rendering based on 1nun.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbol FGF10
External IDs OMIM602115 MGI1099809 HomoloGene3284 GeneCards: FGF10 Gene
Orthologs
Species Human Mouse
Entrez 2255 14165
Ensembl ENSG00000070193 ENSMUSG00000021732
UniProt O15520 O35565
RefSeq (mRNA) NM_004465 NM_008002
RefSeq (protein) NP_004456 NP_032028
Location (UCSC) Chr 5:
44.3 – 44.39 Mb
Chr 13:
118.67 – 118.79 Mb
PubMed search [1] [2]

Fibroblast growth factor 10 is a protein that in humans is encoded by the FGF10 gene.[1][2]

The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This protein exhibits mitogenic activity for keratinizing epidermal cells, but essentially no activity for fibroblasts, which is similar to the biological activity of FGF7. Studies of the mouse homolog of suggested that this gene is required for embryonic epidermal morphogenesis including brain development, lung morphogenesis, and initiation of limb bud formation. This gene is also implicated to be a primary factor in the process of wound healing.[2]

References[edit]

  1. ^ Emoto H, Tagashira S, Mattei MG, Yamasaki M, Hashimoto G, Katsumata T, Negoro T, Nakatsuka M, Birnbaum D, Coulier F, Itoh N (Oct 1997). "Structure and expression of human fibroblast growth factor-10". J Biol Chem 272 (37): 23191–4. doi:10.1074/jbc.272.37.23191. PMID 9287324. 
  2. ^ a b "Entrez Gene: FGF10 fibroblast growth factor 10". 

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