Fibroblast growth factor 10 is a protein that in humans is encoded by the FGF10gene.
The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This protein exhibits mitogenic activity for keratinizing epidermal cells, but essentially no activity for fibroblasts, which is similar to the biological activity of FGF7. Studies of the mouse homolog of suggested that this gene is required for embryonic epidermal morphogenesis including brain development, lung morphogenesis, and initiation of limb bud formation. This gene is also implicated to be a primary factor in the process of wound healing.
Igarashi M, Finch PW, Aaronson SA (1998). "Characterization of recombinant human fibroblast growth factor (FGF)-10 reveals functional similarities with keratinocyte growth factor (FGF-7).". J. Biol. Chem.273 (21): 13230–5. doi:10.1074/jbc.273.21.13230. PMID9582367.
Sekine K, Ohuchi H, Fujiwara M, et al. (1999). "Fgf10 is essential for limb and lung formation.". Nat. Genet.21 (1): 138–41. doi:10.1038/5096. PMID9916808.
Marchese C, Felici A, Visco V, et al. (2001). "Fibroblast growth factor 10 induces proliferation and differentiation of human primary cultured keratinocytes.". J. Invest. Dermatol.116 (4): 623–8. doi:10.1046/j.0022-202x.2001.01280.x. PMID11286634.
Yeh BK, Igarashi M, Eliseenkova AV, et al. (2003). "Structural basis by which alternative splicing confers specificity in fibroblast growth factor receptors.". Proc. Natl. Acad. Sci. U.S.A.100 (5): 2266–71. doi:10.1073/pnas.0436500100. PMID12591959.
Izvolsky KI, Zhong L, Wei L, et al. (2003). "Heparan sulfates expressed in the distal lung are required for Fgf10 binding to the epithelium and for airway branching.". Am. J. Physiol. Lung Cell Mol. Physiol.285 (4): L838–46. doi:10.1152/ajplung.00081.2003. PMID12818887.
Tomlinson DC, Grindley JC, Thomson AA (2004). "Regulation of Fgf10 gene expression in the prostate: identification of transforming growth factor-beta1 and promoter elements.". Endocrinology145 (4): 1988–95. doi:10.1210/en.2003-0842. PMID14726452.
Upadhyay D, Bundesmann M, Panduri V, et al. (2004). "Fibroblast growth factor-10 attenuates H2O2-induced alveolar epithelial cell DNA damage: role of MAPK activation and DNA repair.". Am. J. Respir. Cell Mol. Biol.31 (1): 107–13. doi:10.1165/rcmb.2003-0064OC. PMID14975937.
Theodorou V, Boer M, Weigelt B, et al. (2005). "Fgf10 is an oncogene activated by MMTV insertional mutagenesis in mouse mammary tumors and overexpressed in a subset of human breast carcinomas.". Oncogene23 (36): 6047–55. doi:10.1038/sj.onc.1207816. PMID15208658.
Ibrahimi OA, Yeh BK, Eliseenkova AV, et al. (2005). "Analysis of mutations in fibroblast growth factor (FGF) and a pathogenic mutation in FGF receptor (FGFR) provides direct evidence for the symmetric two-end model for FGFR dimerization.". Mol. Cell. Biol.25 (2): 671–84. doi:10.1128/MCB.25.2.671-684.2005. PMID15632068.
Entesarian M, Matsson H, Klar J, et al. (2005). "Mutations in the gene encoding fibroblast growth factor 10 are associated with aplasia of lacrimal and salivary glands.". Nat. Genet.37 (2): 125–7. doi:10.1038/ng1507. PMID15654336.
Kovacs D, Falchi M, Cardinali G, et al. (2005). "Immunohistochemical analysis of keratinocyte growth factor and fibroblast growth factor 10 expression in psoriasis.". Exp. Dermatol.14 (2): 130–7. doi:10.1111/j.0906-6705.2005.00261.x. PMID15679583.
Ye F, Duvillié B, Scharfmann R (2005). "Fibroblast growth factors 7 and 10 are expressed in the human embryonic pancreatic mesenchyme and promote the proliferation of embryonic pancreatic epithelial cells.". Diabetologia48 (2): 277–81. doi:10.1007/s00125-004-1638-6. PMID15690149.
Beer HD, Bittner M, Niklaus G, et al. (2005). "The fibroblast growth factor binding protein is a novel interaction partner of FGF-7, FGF-10 and FGF-22 and regulates FGF activity: implications for epithelial repair.". Oncogene24 (34): 5269–77. doi:10.1038/sj.onc.1208560. PMID15806171.