FGF17

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Fibroblast growth factor 17
Identifiers
Symbols FGF17 ; FGF-13
External IDs OMIM603725 MGI1202401 HomoloGene2872 GeneCards: FGF17 Gene
RNA expression pattern
PBB GE FGF17 221376 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 8822 14171
Ensembl ENSG00000158815 ENSMUSG00000022101
UniProt O60258 P63075
RefSeq (mRNA) NM_003867 NM_008004
RefSeq (protein) NP_003858 NP_032030
Location (UCSC) Chr 8:
21.9 – 21.91 Mb
Chr 14:
70.64 – 70.64 Mb
PubMed search [1] [2]

Fibroblast growth factor 17 is a protein that in humans is encoded by the FGF17 gene.[1][2][3]

The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes including embryonic development cell growth, morphogenesis, tissue repair, tumor growth and invasion. This gene was shown to be prominently expressed in the cerebellum and cortex. The mouse homolog of this gene was localized to specific sites in the midline structures of the forebrain, the midbrain-hindbrain junction, developing skeleton and developing arteries, which suggests a role in central nervous system, bone and vascular development. This gene was referred to as FGF-13 in reference 2, however, its amino acid sequence and chromosomal localization are identical to FGF17.[3]

References[edit]

  1. ^ Hoshikawa M, Ohbayashi N, Yonamine A, Konishi M, Ozaki K, Fukui S, Itoh N (Apr 1998). "Structure and expression of a novel fibroblast growth factor, FGF-17, preferentially expressed in the embryonic brain". Biochem Biophys Res Commun 244 (1): 187–91. doi:10.1006/bbrc.1998.8239. PMID 9514906. 
  2. ^ Greene JM, Li YL, Yourey PA, Gruber J, Carter KC, Shell BK, Dillon PA, Florence C, Duan DR, Blunt A, Ornitz DM, Ruben SM, Alderson RF (Oct 1998). "Identification and characterization of a novel member of the fibroblast growth factor family". Eur J Neurosci 10 (5): 1911–25. doi:10.1046/j.1460-9568.1998.00211.x. PMID 9751161. 
  3. ^ a b "Entrez Gene: FGF17 fibroblast growth factor 17". 

Further reading[edit]