FGF18

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Fibroblast growth factor 18
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols FGF18 ; FGF-18; ZFGF5
External IDs OMIM603726 MGI1277980 HomoloGene2867 GeneCards: FGF18 Gene
RNA expression pattern
PBB GE FGF18 206987 x at tn.png
PBB GE FGF18 211029 x at tn.png
PBB GE FGF18 211485 s at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 8817 14172
Ensembl ENSG00000156427 ENSMUSG00000057967
UniProt O76093 O89101
RefSeq (mRNA) NM_003862 NM_008005
RefSeq (protein) NP_003853 NP_032031
Location (UCSC) Chr 5:
170.85 – 170.88 Mb
Chr 11:
33.12 – 33.15 Mb
PubMed search [1] [2]

Fibroblast growth factor 18 is a protein that in humans is encoded by the FGF18 gene.[1][2][3]

The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth, and invasion. It has been shown in vitro that this protein is able to induce neurite outgrowth in PC12 cells. FGF18 signals through fibroblast growth factor receptor FGFR3 to promote chondrogenesis [4] and has been shown to cause thickening of cartilage in a murine model of osteoarthritis,[5] and the recombinant version of it (sprifermin) will soon enter trials as a potential treatment for osteoarthritis.[6] Studies of the similar proteins in mouse and chick suggested that this protein is a pleiotropic growth factor that stimulates proliferation in a number of tissues, most notably the liver and small intestine. Knockout studies of the similar gene in mice implied the role of this protein in regulating proliferation and differentiation of midline cerebellar structures.[3]

References[edit]

  1. ^ Ohbayashi N, Hoshikawa M, Kimura S, Yamasaki M, Fukui S, Itoh N (Aug 1998). "Structure and expression of the mRNA encoding a novel fibroblast growth factor, FGF-18". J Biol Chem 273 (29): 18161–4. doi:10.1074/jbc.273.29.18161. PMID 9660775. 
  2. ^ Hu MC, Qiu WR, Wang YP, Hill D, Ring BD, Scully S, Bolon B, DeRose M, Luethy R, Simonet WS, Arakawa T, Danilenko DM (Nov 1998). "FGF-18, a Novel Member of the Fibroblast Growth Factor Family, Stimulates Hepatic and Intestinal Proliferation". Mol Cell Biol 18 (10): 6063–74. PMC 109192. PMID 9742123. 
  3. ^ a b "Entrez Gene: FGF18 fibroblast growth factor 18". 
  4. ^ Davidson, D.; Blanc, A.; Filion, D.; Wang, H.; Plut, P.; Pfeffer, G.; Buschmann, M. D.; Henderson, J. E. (2005). "Fibroblast Growth Factor (FGF) 18 Signals through FGF Receptor 3 to Promote Chondrogenesis". Journal of Biological Chemistry 280 (21): 20509–20515. doi:10.1074/jbc.M410148200. PMID 15781473.  edit
  5. ^ Moore, E.; Bendele, A.; Thompson, D.; Littau, A.; Waggie, K.; Reardon, B.; Ellsworth, J. (2005). "Fibroblast growth factor-18 stimulates chondrogenesis and cartilage repair in a rat model of injury-induced osteoarthritis". Osteoarthritis and Cartilage 13 (7): 623–631. doi:10.1016/j.joca.2005.03.003. PMID 15896984.  edit
  6. ^ Merck Announces Collaboration With Nordic Bioscience for Sprifermin in Osteoarthritis of the Knee, retrieved 2013-04-02 

Further reading[edit]