FGF20

From Wikipedia, the free encyclopedia
Jump to: navigation, search
fibroblast growth factor 20
Identifiers
Symbol FGF20
Entrez 26281
HUGO 3677
OMIM 605558
RefSeq NM_019851
UniProt Q9NP95
Other data
Locus Chr. 8 p22

Fibroblast growth factor 20 is a protein which in humans is encoded by the FGF20 gene.[1]

Function[edit]

The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development,[2] cell growth, morphogenesis, tissue repair, tumor growth and invasion. This gene was shown to be expressed in normal brain, particularly the cerebellum. The rat homolog is preferentially expressed in the brain and able to enhance the survival of midbrain dopaminergic neurons in vitro.[3]

References[edit]

  1. ^ Kirikoshi H, Sagara N, Saitoh T, Tanaka K, Sekihara H, Shiokawa K, Katoh M (August 2000). "Molecular cloning and characterization of human FGF-20 on chromosome 8p21.3-p22". Biochemical and Biophysical Research Communications 274 (2): 337–43. doi:10.1006/bbrc.2000.3142. PMID 10913340. 
  2. ^ Koga C, Adati N, Nakata K, Mikoshiba K, Furuhata Y, Sato S, Tei H, Sakaki Y, Kurokawa T (August 1999). "Characterization of a novel member of the FGF family, XFGF-20, in Xenopus laevis". Biochemical and Biophysical Research Communications 261 (3): 756–65. doi:10.1006/bbrc.1999.1039. PMID 10441498. 
  3. ^ "Entrez Gene: Fibroblast growth factor 20". 

This article incorporates text from the United States National Library of Medicine, which is in the public domain.