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Fibroblast growth factor 3
Symbols FGF3 ; HBGF-3; INT2
External IDs OMIM164950 MGI95517 HomoloGene3841 GeneCards: FGF3 Gene
RNA expression pattern
PBB GE FGF3 214571 at tn.png
More reference expression data
Species Human Mouse
Entrez 2248 14174
Ensembl ENSG00000186895 ENSMUSG00000031074
UniProt P11487 P05524
RefSeq (mRNA) NM_005247 NM_008007
RefSeq (protein) NP_005238 NP_032033
Location (UCSC) Chr 11:
69.62 – 69.63 Mb
Chr 7:
144.84 – 144.84 Mb
PubMed search [1] [2]

INT-2 proto-oncogene protein also known as FGF-3 is a protein that in humans is encoded by the FGF3 gene.[1]


FGF-3 is a member of the fibroblast growth factor family. FGF3 binds to Fibroblast Growth Factor Receptor 3 (FGFR3) to serve as a negative regulator of bone growth during ossification. Effectively, FGF-3 inhibits proliferation of chondrocytes within growth plate.

FGF family members possess broad mitogenic and cell survival activities and are involved in a variety of biological processes including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion.[1]

Clinical significance[edit]

The FGF3 gene was identified by its similarity with mouse fgf3/int-2, a proto-oncogene activated in virally induced mammary tumors in the mouse. Frequent amplification of this gene has been found in human tumors, which may be important for neoplastic transformation and tumor progression. Studies of the similar genes in mouse and chicken suggested the role in inner ear formation.[1] Also, haploinsufficiency in the FGF3 gene is thought to cause otodental syndrome.


FGF3 (gene) has been shown to interact with EBNA1BP2.[2]


Further reading[edit]