FGF4

Fibroblast growth factor 4
PDB rendering based on 1ijt.
Available structures PDB 1ijt
Identifiers
Symbols	FGF4; HBGF-4; HST; HST-1; HSTF1; K-FGF; KFGF
External IDs	OMIM: 164980 MGI: 95518 HomoloGene: 1522 GeneCards: FGF4 Gene
Gene Ontology Molecular function • fibroblast growth factor receptor binding • growth factor activity • heparin binding Cellular component • extracellular region • extracellular region • soluble fraction Biological process • cartilage condensation • signal transduction • cell-cell signaling • positive regulation of cell proliferation • insulin receptor signaling pathway • fibroblast growth factor receptor signaling pathway • fibroblast growth factor receptor signaling pathway • fibroblast growth factor receptor signaling pathway • mesenchymal cell proliferation • positive regulation of gene expression • stem cell maintenance • embryonic hindlimb morphogenesis • odontogenesis of dentine-containing tooth • negative regulation of apoptosis • positive regulation of cell division • cranial suture morphogenesis • apoptosis involved in morphogenesis • chondroblast differentiation • positive regulation of ERK1 and ERK2 cascade Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	2249	14175
Ensembl	ENSG00000075388	ENSMUSG00000050917
UniProt	P08620	Q542N0
RefSeq (mRNA)	NM_002007	NM_010202.5
RefSeq (protein)	NP_001998	NP_034332.2
Location (UCSC)	Chr 11: 69.59 – 69.59 Mb	Chr 7: 152.05 – 152.05 Mb
PubMed search	[1]	[2]

Fibroblast growth factor 4 is a protein that in humans is encoded by the FGF4 gene.

The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities and are involved in a variety of biological processes including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This gene was identified by its oncogenic transforming activity. This gene and FGF3, another oncogenic growth factor, are located closely on chromosome 11. Co-amplification of both genes was found in various kinds of human tumors. Studies on the mouse homolog suggested a function in bone morphogenesis and limb development through the sonic hedgehog (SHH) signaling pathway.

Further reading

• Powers CJ, McLeskey SW, Wellstein A (2000). "Fibroblast growth factors, their receptors and signaling.". Endocr. Relat. Cancer 7 (3): 165–97. doi:10.1677/erc.0.0070165. PMID 11021964. 
• Taira M, Yoshida T, Miyagawa K, et al. (1987). "cDNA sequence of human transforming gene hst and identification of the coding sequence required for transforming activity". Proc. Natl. Acad. Sci. U.S.A. 84 (9): 2980–4. doi:10.1073/pnas.84.9.2980. PMC 304784. PMID 2953031. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=304784. 
• Delli Bovi P, Curatola AM, Kern FG, et al. (1987). "An oncogene isolated by transfection of Kaposi's sarcoma DNA encodes a growth factor that is a member of the FGF family". Cell 50 (5): 729–37. doi:10.1016/0092-8674(87)90331-X. PMID 2957062. 
• Yoshida T, Miyagawa K, Odagiri H, et al. (1987). "Genomic sequence of hst, a transforming gene encoding a protein homologous to fibroblast growth factors and the int-2-encoded protein". Proc. Natl. Acad. Sci. U.S.A. 84 (20): 7305–9. doi:10.1073/pnas.84.20.7305. PMC 299281. PMID 2959959. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=299281. 
• Wada A, Sakamoto H, Katoh O, et al. (1989). "Two homologous oncogenes, HST1 and INT2, are closely located in human genome". Biochem. Biophys. Res. Commun. 157 (2): 828–35. doi:10.1016/S0006-291X(88)80324-3. PMID 2974287. 
• Huebner K, Ferrari AC, Delli Bovi P, et al. (1989). "The FGF-related oncogene, K-FGF, maps to human chromosome region 11q13, possibly near int-2". Oncogene Res. 3 (3): 263–70. PMID 3060803. 
• Adelaide J, Mattei MG, Marics I, et al. (1988). "Chromosomal localization of the hst oncogene and its co-amplification with the int.2 oncogene in a human melanoma". Oncogene 2 (4): 413–6. PMID 3283658. 
• Ornitz DM, Xu J, Colvin JS, et al. (1996). "Receptor specificity of the fibroblast growth factor family". J. Biol. Chem. 271 (25): 15292–7. doi:10.1074/jbc.271.25.15292. PMID 8663044. 
• Helland R, Berglund GI, Otlewski J, et al. (1999). "High-resolution structures of three new trypsin-squash-inhibitor complexes: a detailed comparison with other trypsins and their complexes". Acta Crystallogr. D Biol. Crystallogr. 55 (Pt 1): 139–48. doi:10.1107/S090744499801052X. PMID 10089404. 
• Bellosta P, Iwahori A, Plotnikov AN, et al. (2001). "Identification of Receptor and Heparin Binding Sites in Fibroblast Growth Factor 4 by Structure-Based Mutagenesis". Mol. Cell. Biol. 21 (17): 5946–57. doi:10.1128/MCB.21.17.5946-5957.2001. PMC 87313. PMID 11486033. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=87313. 
• Britto JA, Evans RD, Hayward RD, Jones BM (2002). "From genotype to phenotype: the differential expression of FGF, FGFR, and TGFbeta genes characterizes human cranioskeletal development and reflects clinical presentation in FGFR syndromes". Plast. Reconstr. Surg. 108 (7): 2026–39; discussion 2040–6. doi:10.1097/00006534-200112000-00030. PMID 11743396. 
• Yamamoto H, Ochiya T, Tamamushi S, et al. (2002). "HST-1/FGF-4 gene activation induces spermatogenesis and prevents adriamycin-induced testicular toxicity". Oncogene 21 (6): 899–908. doi:10.1038/sj.onc.1205135. PMID 11840335. 
• Sieuwerts AM, Martens JW, Dorssers LC, et al. (2003). "Differential effects of fibroblast growth factors on expression of genes of the plasminogen activator and insulin-like growth factor systems by human breast fibroblasts". Thromb. Haemost. 87 (4): 674–83. PMID 12008951. 
• Koh KR, Ohta K, Nakamae H, et al. (2002). "Differential effects of fibroblast growth factor-4, epidermal growth factor and transforming growth factor-beta1 on functional development of stromal layers in acute myeloid leukemia". Leuk. Res. 26 (10): 933–8. doi:10.1016/S0145-2126(02)00033-4. PMID 12163055. 
• Lopez-Sanchez C, Climent V, Schoenwolf GC, et al. (2003). "Induction of cardiogenesis by Hensen's node and fibroblast growth factors". Cell Tissue Res. 309 (2): 237–49. doi:10.1007/s00441-002-0567-2. PMID 12172783. 
• Wang P, Branch DR, Bali M, et al. (2003). "The POU homeodomain protein OCT3 as a potential transcriptional activator for fibroblast growth factor-4 (FGF-4) in human breast cancer cells". Biochem. J. 375 (Pt 1): 199–205. doi:10.1042/BJ20030579. PMC 1223663. PMID 12841847. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1223663. 
• Reményi A, Lins K, Nissen LJ, et al. (2003). "Crystal structure of a POU/HMG/DNA ternary complex suggests differential assembly of Oct4 and Sox2 on two enhancers". Genes Dev. 17 (16): 2048–59. doi:10.1101/gad.269303. PMC 196258. PMID 12923055. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=196258. 
• Hirai K, Sasaki H, Yamamoto H, et al. (2004). "HST-1/FGF-4 protects male germ cells from apoptosis under heat-stress condition". Exp. Cell Res. 294 (1): 77–85. doi:10.1016/j.yexcr.2003.11.012. PMID 14980503.