The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This gene was identified as an oncogene, which confers transforming potential when transfected into mammalian cells. Targeted disruption of the homolog of this gene in mouse resulted in the phenotype of abnormally long hair, which suggested a function as an inhibitor of hair elongation. Alternatively spliced transcript variants encoding different isoforms have been identified.
The disruption of FGF5 expression in mammals increases the length of the anagen (growth) phase of the hair cycle, resulting in a phenotype of extremely long hair. This has been shown in many species, including cats, dogs, mice, rabbits, sheep and goats (the so-called angora mutation) and even elephants and mammoths. FGF5 also affects the hair cycle in humans; blocking FGF5 in the human scalp (by applying a herbal extract that blocked FGF5) extends the hair cycle, resulting in less hair fall and increased hair growth.
^Nguyen C, Roux D, Mattei MG, de Lapeyriere O, Goldfarb M, Birnbaum D, Jordan BR (Apr 1994). "The FGF-related oncogenes hst and int.2, and the bcl.1 locus are contained within one megabase in band q13 of chromosome 11, while the fgf.5 oncogene maps to 4q21". Oncogene3 (6): 703–8. PMID2577873.
^4. Drogemuller, C., S. Rufenacht, et al. (2007). "Mutations within the FGF5 gene are associated with hair length in cats." Anim Genet 38(3): 218-221. PMID 17433015.
^5. Cadieu, E., M. W. Neff, et al. (2009). "Coat variation in the domestic dog is governed by variants in three genes." Science 326(5949): 150-153. PMID 19713490.
^6. Hebert, J. M., T. Rosenquist, et al. (1994). "FGF5 as a regulator of the hair growth cycle: evidence from targeted and spontaneous mutations." Cell 78(6): 1017-1025. PMID 7923352.
^7. Li, C. X., M. S. Jiang, et al. (2008). "[Correlation analysis between single nucleotide polymorphism of FGF5 gene and wool yield in rabbits]." Yi Chuan 30(7): 893-899. PMID 18779133.
^8. Allain, D. and C. Renieri (2010). "Genetics of fibre production and fleece characteristics in small ruminants, Angora rabbit and South American camelids." Animal 4(9): 1472-1481. PMID 22444694.
^9. Roca, A. L., Y. Ishida, et al. (2009). "Genetic variation at hair length candidate genes in elephants and the extinct woolly mammoth." BMC Evol Biol 9: 232. PMID 19747392.
^10. Maeda, T., T. Yamamoto, et al. (2007). "Sanguisorba Officinalis Root Extract Has FGF-5 Inhibitory Activity and Reduces Hair Loss by Causing Prolongation of the Anagen Period" Nishinihon Journal of Dermatology 69(1): 81-86.
Li K, Stewart DJ, Ward HJ (2001). "Technology evaluation: gene therapy (FGF-5), Vical". Curr. Opin. Mol. Ther.1 (2): 260–5. PMID11715949.
Werner S, Roth WK, Bates B et al. (1991). "Fibroblast growth factor 5 proto-oncogene is expressed in normal human fibroblasts and induced by serum growth factors". Oncogene6 (11): 2137–44. PMID1658709.CS1 maint: Explicit use of et al. (link)
Hébert JM, Rosenquist T, Götz J, Martin GR (1994). "FGF5 as a regulator of the hair growth cycle: evidence from targeted and spontaneous mutations". Cell78 (6): 1017–25. doi:10.1016/0092-8674(94)90276-3. PMID7923352.
Clements DA, Wang JK, Dionne CA, Goldfarb M (1993). "Activation of fibroblast growth factor (FGF) receptors by recombinant human FGF-5". Oncogene8 (5): 1311–6. PMID8386828.
Ornitz DM, Xu J, Colvin JS et al. (1996). "Receptor specificity of the fibroblast growth factor family". J. Biol. Chem.271 (25): 15292–7. doi:10.1074/jbc.271.25.15292. PMID8663044.CS1 maint: Explicit use of et al. (link)
Kitaoka T, Morse LS, Schneeberger S et al. (1997). "Expression of FGF5 in choroidal neovascular membranes associated with ARMD". Curr. Eye Res.16 (4): 396–9. doi:10.1076/ceyr.16.4.396.10685. PMID9134330.CS1 maint: Explicit use of et al. (link)
Schneeberger SA, Hjelmeland LM, Tucker RP, Morse LS (1997). "Vascular endothelial growth factor and fibroblast growth factor 5 are colocalized in vascular and avascular epiretinal membranes". Am. J. Ophthalmol.124 (4): 447–54. doi:10.1016/s0002-9394(14)70861-x. PMID9323936.
Kornmann M, Ishiwata T, Beger HG, Korc M (1997). "Fibroblast growth factor-5 stimulates mitogenic signaling and is overexpressed in human pancreatic cancer: evidence for autocrine and paracrine actions". Oncogene15 (12): 1417–24. doi:10.1038/sj.onc.1201307. PMID9333017.
Ozawa K, Suzuki S, Asada M et al. (1998). "An alternatively spliced fibroblast growth factor (FGF)-5 mRNA is abundant in brain and translates into a partial agonist/antagonist for FGF-5 neurotrophic activity". J. Biol. Chem.273 (44): 29262–71. doi:10.1074/jbc.273.44.29262. PMID9786939.CS1 maint: Explicit use of et al. (link)
de Vries CJ, van Achterberg TA, Horrevoets AJ et al. (2000). "Differential display identification of 40 genes with altered expression in activated human smooth muscle cells. Local expression in atherosclerotic lesions of smags, smooth muscle activation-specific genes". J. Biol. Chem.275 (31): 23939–47. doi:10.1074/jbc.M910099199. PMID10823842.CS1 maint: Explicit use of et al. (link)
Hanada K, Perry-Lalley DM, Ohnmacht GA et al. (2001). "Identification of fibroblast growth factor-5 as an overexpressed antigen in multiple human adenocarcinomas". Cancer Res.61 (14): 5511–6. PMID11454700.CS1 maint: Explicit use of et al. (link)
Kornmann M, Lopez ME, Beger HG, Korc M (2002). "Expression of the IIIc variant of FGF receptor-1 confers mitogenic responsiveness to heparin and FGF-5 in TAKA-1 pancreatic ductal cells". Int. J. Pancreatol.29 (2): 85–92. doi:10.1385/IJGC:29:2:085. PMID11876253.
Sieuwerts AM, Martens JW, Dorssers LC et al. (2003). "Differential effects of fibroblast growth factors on expression of genes of the plasminogen activator and insulin-like growth factor systems by human breast fibroblasts". Thromb. Haemost.87 (4): 674–83. PMID12008951.CS1 maint: Explicit use of et al. (link)