FGF7

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Fibroblast growth factor 7
Protein FGF7 PDB 1qqk.png
PDB rendering based on 1qqk.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols FGF7 ; HBGF-7; KGF
External IDs OMIM148180 MGI95521 HomoloGene7316 GeneCards: FGF7 Gene
RNA expression pattern
PBB GE FGF7 205782 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 2252 14178
Ensembl ENSG00000140285 ENSMUSG00000027208
UniProt P21781 P36363
RefSeq (mRNA) NM_002009 NM_008008
RefSeq (protein) NP_002000 NP_032034
Location (UCSC) Chr 15:
49.72 – 50.15 Mb
Chr 2:
126.03 – 126.09 Mb
PubMed search [1] [2]

Keratinocyte growth factor is a protein that in humans is encoded by the FGF7 gene.[1][2][3]

The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This protein is a potent epithelial cell-specific growth factor, whose mitogenic activity is predominantly exhibited in keratinocytes but not in fibroblasts and endothelial cells. Studies of mouse and rat homologs of this gene implicated roles in morphogenesis of epithelium, reepithelialization of wounds, hair development and early lung organogenesis.[3]

Interactions[edit]

FGF7 has been shown to interact with Perlecan.[4]

References[edit]

  1. ^ Mattei MG, deLapeyriere O, Bresnick J, Dickson C, Birnbaum D, Mason I (June 1995). "Mouse Fgf7 (fibroblast growth factor 7) and Fgf8 (fibroblast growth factor 8) genes map to chromosomes 2 and 19 respectively". Mamm Genome 6 (3): 196–7. doi:10.1007/BF00293012. PMID 7749227. 
  2. ^ Kelley MJ, Pech M, Seuanez HN, Rubin JS, O'Brien SJ, Aaronson SA (November 1992). "Emergence of the keratinocyte growth factor multigene family during the great ape radiation". Proc Natl Acad Sci U S A 89 (19): 9287–91. doi:10.1073/pnas.89.19.9287. PMC 50111. PMID 1409637. 
  3. ^ a b "Entrez Gene: FGF7 fibroblast growth factor 7 (keratinocyte growth factor)". 
  4. ^ Mongiat, M; Taylor K; Otto J; Aho S; Uitto J; Whitelock J M; Iozzo R V (March 2000). "The protein core of the proteoglycan perlecan binds specifically to fibroblast growth factor-7". J. Biol. Chem. (UNITED STATES) 275 (10): 7095–100. doi:10.1074/jbc.275.10.7095. ISSN 0021-9258. PMID 10702276. 

Further reading[edit]