FGF8

Fibroblast growth factor 8 (androgen-induced)
PDB rendering based on 2fdb.
Available structures PDB 2fdb
Identifiers
Symbols	FGF8; AIGF; FGF-8; HBGF-8; KAL6; MGC149376
External IDs	OMIM: 600483 MGI: 99604 HomoloGene: 7715 GeneCards: FGF8 Gene
Gene Ontology Molecular function • type 1 fibroblast growth factor receptor binding • type 2 fibroblast growth factor receptor binding • growth factor activity • growth factor activity Cellular component • extracellular region • extracellular region • extracellular space Biological process • metanephros development • mesonephros development • gastrulation • positive regulation of cell proliferation • insulin receptor signaling pathway • gonad development • fibroblast growth factor receptor signaling pathway • fibroblast growth factor receptor signaling pathway • fibroblast growth factor receptor signaling pathway • anatomical structure morphogenesis • odontogenesis • positive regulation of cell division • negative regulation of cardiac muscle tissue development • bone development • neuroepithelial cell differentiation • dopaminergic neuron differentiation Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	2253	14179
Ensembl	ENSG00000107831	ENSMUSG00000025219
UniProt	P55075	P37237
RefSeq (mRNA)	NM_001206389.1	NM_010205
RefSeq (protein)	NP_001193318.1	NP_034335
Location (UCSC)	Chr 10: 103.53 – 103.54 Mb	Chr 19: 45.81 – 45.82 Mb
PubMed search	[1]	[2]

Fibroblast growth factor 8 is a protein that in humans is encoded by the FGF8 gene.

The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This protein is known to be a factor that supports androgen and anchorage independent growth of mammary tumor cells. Overexpression of this gene has been shown to increase tumor growth and angiogensis. The adult expression of this gene is restricted to testes and ovaries. Temporal and spatial pattern of this gene expression suggests its function as an embryonic epithelial factor. Studies of the mouse and chick homologs revealed roles in midbrain and limb development, organogenesis, embryo gastrulation and left-right axis determination. The alternative splicing of this gene results in four transcript variants.

Further reading

• Powers CJ, McLeskey SW, Wellstein A (2000). "Fibroblast growth factors, their receptors and signaling.". Endocr. Relat. Cancer 7 (3): 165–97. doi:10.1677/erc.0.0070165. PMID 11021964. 
• Mattila MM, Härkönen PL (2007). "Role of fibroblast growth factor 8 in growth and progression of hormonal cancer.". Cytokine Growth Factor Rev. 18 (3–4): 257–66. doi:10.1016/j.cytogfr.2007.04.010. PMID 17512240. 
• Duester G (2007). "Retinoic acid regulation of the somitogenesis clock". Birth Defects Res. C Embryo Today 81 (2): 84–92. doi:10.1002/bdrc.20092. PMC 2235195. PMID 17600781. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2235195. 
• Tanaka A, Miyamoto K, Matsuo H, et al. (1995). "Human androgen-induced growth factor in prostate and breast cancer cells: its molecular cloning and growth properties". FEBS Lett. 363 (3): 226–30. doi:10.1016/0014-5793(95)00324-3. PMID 7737407. 
• Gemel J, Gorry M, Ehrlich GD, MacArthur CA (1996). "Structure and sequence of human FGF8". Genomics 35 (1): 253–7. doi:10.1006/geno.1996.0349. PMID 8661131. 
• Ornitz DM, Xu J, Colvin JS, et al. (1996). "Receptor specificity of the fibroblast growth factor family". J. Biol. Chem. 271 (25): 15292–7. doi:10.1074/jbc.271.25.15292. PMID 8663044. 
• Payson RA, Wu J, Liu Y, Chiu IM (1996). "The human FGF-8 gene localizes on chromosome 10q24 and is subjected to induction by androgen in breast cancer cells". Oncogene 13 (1): 47–53. PMID 8700553. 
• Ghosh AK, Shankar DB, Shackleford GM, et al. (1997). "Molecular cloning and characterization of human FGF8 alternative messenger RNA forms". Cell Growth Differ. 7 (10): 1425–34. PMID 8891346. 
• Yoshiura K, Leysens NJ, Chang J, et al. (1997). "Genomic structure, sequence, and mapping of human FGF8 with no evidence for its role in craniosynostosis/limb defect syndromes". Am. J. Med. Genet. 72 (3): 354–62. doi:10.1002/(SICI)1096-8628(19971031)72:3<354::AID-AJMG21>3.0.CO;2-R. PMID 9332670. 
• Chellaiah A, Yuan W, Chellaiah M, Ornitz DM (2000). "Mapping ligand binding domains in chimeric fibroblast growth factor receptor molecules. Multiple regions determine ligand binding specificity". J. Biol. Chem. 274 (49): 34785–94. doi:10.1074/jbc.274.49.34785. PMID 10574949. 
• Loo BB, Darwish KK, Vainikka SS, et al. (2001). "Production and characterization of the extracellular domain of recombinant human fibroblast growth factor receptor 4". Int. J. Biochem. Cell Biol. 32 (5): 489–97. doi:10.1016/S1357-2725(99)00145-4. PMID 10736564. 
• Xu J, Liu Z, Ornitz DM (2000). "Temporal and spatial gradients of Fgf8 and Fgf17 regulate proliferation and differentiation of midline cerebellar structures". Development 127 (9): 1833–43. PMID 10751172. 
• Tanaka S, Ueo H, Mafune K, et al. (2001). "A novel isoform of human fibroblast growth factor 8 is induced by androgens and associated with progression of esophageal carcinoma". Dig. Dis. Sci. 46 (5): 1016–21. doi:10.1023/A:1010753826788. PMID 11341643. 
• Ruohola JK, Viitanen TP, Valve EM, et al. (2001). "Enhanced invasion and tumor growth of fibroblast growth factor 8b-overexpressing MCF-7 human breast cancer cells". Cancer Res. 61 (10): 4229–37. PMID 11358849. 
• Mattila MM, Ruohola JK, Valve EM, et al. (2001). "FGF-8b increases angiogenic capacity and tumor growth of androgen-regulated S115 breast cancer cells". Oncogene 20 (22): 2791–804. doi:10.1038/sj.onc.1204430. PMID 11420691. 
• Zammit C, Coope R, Gomm JJ, et al. (2002). "Fibroblast growth factor 8 is expressed at higher levels in lactating human breast and in breast cancer". Br. J. Cancer 86 (7): 1097–103. doi:10.1038/sj.bjc.6600213. PMC 2364190. PMID 11953856. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2364190. 
• Brondani V, Klimkait T, Egly JM, Hamy F (2002). "Promoter of FGF8 reveals a unique regulation by unliganded RARalpha". J. Mol. Biol. 319 (3): 715–28. doi:10.1016/S0022-2836(02)00376-5. PMID 12054865. 
• Gnanapragasam VJ, Robson CN, Neal DE, Leung HY (2002). "Regulation of FGF8 expression by the androgen receptor in human prostate cancer". Oncogene 21 (33): 5069–80. doi:10.1038/sj.onc.1205663. PMID 12140757. 

External links

• GeneReviews/NCBI/NIH/UW entry on Kallmann syndrome