Fibroblast growth factor receptor-like 1

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Fibroblast growth factor receptor-like 1
Identifiers
Symbols FGFRL1 ; FGFR5; FHFR
External IDs OMIM605830 MGI2150920 HomoloGene11067 GeneCards: FGFRL1 Gene
EC number 3.2.1.76
RNA expression pattern
PBB GE FGFRL1 gnf1h00389 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 53834 116701
Ensembl ENSG00000127418 ENSMUSG00000008090
UniProt Q8N441 Q91V87
RefSeq (mRNA) NM_001004356 NM_001164259
RefSeq (protein) NP_001004356 NP_001157731
Location (UCSC) Chr 4:
1 – 1.02 Mb
Chr 5:
108.69 – 108.71 Mb
PubMed search [1] [2]

Fibroblast growth factor receptor-like 1 is a protein that in humans is encoded by the FGFRL1 gene.[1]

The protein encoded by this gene is a member of the fibroblast growth factor receptor (FGFR) family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein would consist of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. A marked difference between this gene product and the other family members is its lack of a cytoplasmic tyrosine kinase domain. The result is a transmembrane receptor that could interact with other family members and potentially inhibit signaling. Multiple alternatively spliced transcript variants encoding the same isoform have been found for this gene.[1]

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