FGG

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This article is about the gene. For the sports organization, see Federation of Gay Games. For the Susumu Hirasawa song, see The Ghost in Science.
Fibrinogen gamma chain
Protein FGG PDB 1fib.png
PDB rendering based on 1fib.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbol FGG
External IDs OMIM134850 MGI95526 HomoloGene429 ChEMBL: 4058 GeneCards: FGG Gene
RNA expression pattern
PBB GE FGG 219612 s at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 2266 99571
Ensembl ENSG00000171557 ENSMUSG00000033860
UniProt P02679 Q8VCM7
RefSeq (mRNA) NM_000509 NM_133862
RefSeq (protein) NP_000500 NP_598623
Location (UCSC) Chr 4:
155.53 – 155.53 Mb
Chr 3:
83.01 – 83.02 Mb
PubMed search [1] [2]

Fibrinogen gamma chain, also known as FGG, is a human gene found on Chromosome 4.

The protein encoded by this gene is the gamma component of fibrinogen, a blood-borne glycoprotein composed of three pairs of nonidentical polypeptide chains. Following vascular injury, fibrinogen is cleaved by thrombin to form fibrin which is the most abundant component of blood clots. In addition, various cleavage products of fibrinogen and fibrin regulate cell adhesion and spreading, display vasoconstrictor and chemotactic activities, and are mitogens for several cell types. Mutations in this gene lead to several disorders, including dysfibrinogenemia, hypofibrinogenemia and thrombophilia.[1] Alternative splicing of the mRNA chain results in two transcript variants; the common γA chain and the alternatively spliced γ' chain. Approximately 10% of the total plasma fibrinogen consists of γA/γ' fibrinogen, with <1% consisting of γ'/γ' fibrinogen. Increased and decreased levels of γA/γ' fibrinogen have been associated with CAD and DVT respectively.

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