FGR (gene)

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FGR proto-oncogene, Src family tyrosine kinase
Identifiers
Symbols FGR ; SRC2; c-fgr; c-src2; p55-Fgr; p55c-fgr; p58-Fgr; p58c-fgr
External IDs OMIM164940 MGI95527 HomoloGene3842 ChEMBL: 4454 GeneCards: FGR Gene
EC number 2.7.10.2
RNA expression pattern
PBB GE FGR 208438 s at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 2268 14191
Ensembl ENSG00000000938 ENSMUSG00000028874
UniProt P09769 P14234
RefSeq (mRNA) NM_001042729 NM_010208
RefSeq (protein) NP_001036194 NP_034338
Location (UCSC) Chr 1:
27.94 – 27.96 Mb
Chr 4:
132.97 – 133 Mb
PubMed search [1] [2]

Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog, also known as FGR, is a protein which in humans is encoded by the FGR gene.[1][2]

Function[edit]

This gene is a member of the Src family of protein tyrosine kinases (PTKs). The encoded protein contains N-terminal sites for myristoylation and palmitoylation, a PTK domain, and SH2 and SH3 domains which are involved in mediating protein-protein interactions with phosphotyrosine-containing and proline-rich motifs, respectively. The protein localizes to plasma membrane ruffles, and functions as a negative regulator of cell migration and adhesion triggered by the beta-2 integrin signal transduction pathway. Infection with Epstein-Barr virus results in the overexpression of this gene. Multiple alternatively spliced variants, encoding the same protein, have been identified.[2]

Discovery[edit]

The feline version of this gene was discovered by Suraiya Rasheed, Murray Gardner, and co-workers.[3]

Interactions[edit]

FGR (gene) has been shown to interact with Wiskott-Aldrich syndrome protein.[4][5][6]

References[edit]

  1. ^ Tronick SR, Popescu NC, Cheah MS, Swan DC, Amsbaugh SC, Lengel CR et al. (Oct 1985). "Isolation and chromosomal localization of the human fgr protooncogene, a distinct member of the tyrosine kinase gene family". Proceedings of the National Academy of Sciences of the United States of America 82 (19): 6595–9. doi:10.1073/pnas.82.19.6595. PMC 391256. PMID 2995972. 
  2. ^ a b "Entrez Gene: FGR Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog". 
  3. ^ Rasheed S, Barbacid M, Aaronson S, Gardner MB (Feb 1982). "Origin and biological properties of a new feline sarcoma virus". Virology 117 (1): 238–44. doi:10.1016/0042-6822(82)90522-0. PMID 6175084. 
  4. ^ Banin S, Truong O, Katz DR, Waterfield MD, Brickell PM, Gout I (Aug 1996). "Wiskott-Aldrich syndrome protein (WASp) is a binding partner for c-Src family protein-tyrosine kinases". Current Biology 6 (8): 981–8. doi:10.1016/S0960-9822(02)00642-5. PMID 8805332. 
  5. ^ Finan PM, Soames CJ, Wilson L, Nelson DL, Stewart DM, Truong O et al. (Oct 1996). "Identification of regions of the Wiskott-Aldrich syndrome protein responsible for association with selected Src homology 3 domains". The Journal of Biological Chemistry 271 (42): 26291–5. doi:10.1074/jbc.271.42.26291. PMID 8824280. 
  6. ^ Rivero-Lezcano OM, Marcilla A, Sameshima JH, Robbins KC (Oct 1995). "Wiskott-Aldrich syndrome protein physically associates with Nck through Src homology 3 domains". Molecular and Cellular Biology 15 (10): 5725–31. PMC 230823. PMID 7565724. 

Further reading[edit]