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Four and a half LIM domains 2
Protein FHL2 PDB 1x4k.png
PDB rendering based on 1x4k.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols FHL2 ; AAG11; DRAL; FHL-2; SLIM-3; SLIM3
External IDs OMIM602633 MGI1338762 HomoloGene20372 GeneCards: FHL2 Gene
RNA expression pattern
PBB GE FHL2 202949 s at tn.png
More reference expression data
Species Human Mouse
Entrez 2274 14200
Ensembl ENSG00000115641 ENSMUSG00000008136
UniProt Q14192 O70433
RefSeq (mRNA) NM_001039492 NM_001289533
RefSeq (protein) NP_001034581 NP_001276462
Location (UCSC) Chr 2:
105.97 – 106.05 Mb
Chr 1:
43.12 – 43.16 Mb
PubMed search [1] [2]

Four and a half LIM domains protein 2 is a protein that in humans is encoded by the FHL2 gene.[1]

LIM proteins contain a highly conserved double zinc finger motif called the LIM domain.[supplied by OMIM][2]


FHL2 has been shown to interact with Beta-catenin,[3] Titin,[4] Zinc finger and BTB domain-containing protein 16,[5] Integrin, beta 6,[6] Androgen receptor,[7] ITGA7,[8] CREB1,[9] MAPK1,[10] CD49c,[6] ZNF638,[11] BRCA1,[12][13] FHL3,[9][14] IGFBP5,[15] TRAF6,[16] EIF6,[6] CD18,[6] CD29[6] and PSEN2.[17]


  1. ^ Morgan MJ, Madgwick AJ (October 1996). "Slim defines a novel family of LIM-proteins expressed in skeletal muscle". Biochem. Biophys. Res. Commun. 225 (2): 632–8. doi:10.1006/bbrc.1996.1222. PMID 8753811. 
  2. ^ "Entrez Gene: FHL2 four and a half LIM domains 2". 
  3. ^ Wei, Yu; Renard Claire-Angélique; Labalette Charlotte; Wu Yuanfei; Lévy Laurence; Neuveut Christine; Prieur Xavier; Flajolet Marc; Prigent Sylvie; Buendia Marie-Annick (February 2003). "Identification of the LIM protein FHL2 as a coactivator of beta-catenin". J. Biol. Chem. (United States) 278 (7): 5188–94. doi:10.1074/jbc.M207216200. ISSN 0021-9258. PMID 12466281. 
  4. ^ Lange, Stephan; Auerbach Daniel; McLoughlin Patricia; Perriard Evelyne; Schäfer Beat W; Perriard Jean-Claude; Ehler Elisabeth (December 2002). "Subcellular targeting of metabolic enzymes to titin in heart muscle may be mediated by DRAL/FHL-2". J. Cell. Sci. (England) 115 (Pt 24): 4925–36. doi:10.1242/jcs.00181. ISSN 0021-9533. PMID 12432079. 
  5. ^ McLoughlin, Patricia; Ehler Elisabeth; Carlile Graeme; Licht Jonathan D; Schäfer Beat W (October 2002). "The LIM-only protein DRAL/FHL2 interacts with and is a corepressor for the promyelocytic leukemia zinc finger protein". J. Biol. Chem. (United States) 277 (40): 37045–53. doi:10.1074/jbc.M203336200. ISSN 0021-9258. PMID 12145280. 
  6. ^ a b c d e Wixler, V; Geerts D; Laplantine E; Westhoff D; Smyth N; Aumailley M; Sonnenberg A; Paulsson M (October 2000). "The LIM-only protein DRAL/FHL2 binds to the cytoplasmic domain of several alpha and beta integrin chains and is recruited to adhesion complexes". J. Biol. Chem. (UNITED STATES) 275 (43): 33669–78. doi:10.1074/jbc.M002519200. ISSN 0021-9258. PMID 10906324. 
  7. ^ Müller, J M; Isele U; Metzger E; Rempel A; Moser M; Pscherer A; Breyer T; Holubarsch C; Buettner R; Schüle R (February 2000). "FHL2, a novel tissue-specific coactivator of the androgen receptor". EMBO J. (ENGLAND) 19 (3): 359–69. doi:10.1093/emboj/19.3.359. ISSN 0261-4189. PMC 305573. PMID 10654935. 
  8. ^ Samson, Thomas; Smyth Neil; Janetzky Stefanie; Wendler Olaf; Müller Judith M; Schüle Roland; von der Mark Helga; von der Mark Klaus; Wixler Viktor (July 2004). "The LIM-only proteins FHL2 and FHL3 interact with alpha- and beta-subunits of the muscle alpha7beta1 integrin receptor". J. Biol. Chem. (United States) 279 (27): 28641–52. doi:10.1074/jbc.M312894200. ISSN 0021-9258. PMID 15117962. 
  9. ^ a b Fimia, G M; De Cesare D, Sassone-Corsi P (November 2000). "A Family of LIM-Only Transcriptional Coactivators: Tissue-Specific Expression and Selective Activation of CREB and CREM". Mol. Cell. Biol. (UNITED STATES) 20 (22): 8613–22. doi:10.1128/MCB.20.22.8613-8622.2000. ISSN 0270-7306. PMC 102166. PMID 11046156. 
  10. ^ Purcell, Nicole H; Darwis Dina; Bueno Orlando F; Müller Judith M; Schüle Roland; Molkentin Jeffery D (February 2004). "Extracellular Signal-Regulated Kinase 2 Interacts with and Is Negatively Regulated by the LIM-Only Protein FHL2 in Cardiomyocytes". Mol. Cell. Biol. (United States) 24 (3): 1081–95. doi:10.1128/MCB.24.3.1081-1095.2004. ISSN 0270-7306. PMC 321437. PMID 14729955. 
  11. ^ Ng, Enders Kai On; Chan Kwok Keung; Wong Chi Hang; Tsui Stephen Kwok Wing; Ngai Sai Ming; Lee Simon Ming Yuen; Kotaka Masayo; Lee Cheuk Yu; Waye Mary Miu Yee; Fung Kwok Pui (2002). "Interaction of the heart-specific LIM domain protein, FHL2, with DNA-binding nuclear protein, hNP220". J. Cell. Biochem. (United States) 84 (3): 556–66. doi:10.1002/jcb.10041. ISSN 0730-2312. PMID 11813260. 
  12. ^ Yan, Jinghua; Zhu Jianhua; Zhong Hongjun; Lu Qiujun; Huang Cuifen; Ye Qinong (October 2003). "BRCA1 interacts with FHL2 and enhances FHL2 transactivation function". FEBS Lett. (Netherlands) 553 (1–2): 183–9. doi:10.1016/S0014-5793(03)00978-5. ISSN 0014-5793. PMID 14550570. 
  13. ^ Yan, Jing-Hua; Ye Qi-Nong; Zhu Jian-Hua; Zhong Hong-Jun; Zheng Hui-Yong; Huang Cui-Fen (December 2003). "[Isolation and characterization of a BRCA1-interacting protein]". Yi Chuan Xue Bao (China) 30 (12): 1161–6. ISSN 0379-4172. PMID 14986435. 
  14. ^ Li, H Y; Ng E K; Lee S M; Kotaka M; Tsui S K; Lee C Y; Fung K P; Waye M M (2001). "Protein-protein interaction of FHL3 with FHL2 and visualization of their interaction by green fluorescent proteins (GFP) two-fusion fluorescence resonance energy transfer (FRET)". J. Cell. Biochem. (United States) 80 (3): 293–303. doi:10.1002/1097-4644(20010301)80:3<293::AID-JCB10>3.0.CO;2-U. ISSN 0730-2312. PMID 11135358. 
  15. ^ Amaar, Yousef G; Thompson Garrett R; Linkhart Thomas A; Chen Shin-Tai; Baylink David J; Mohan Subburaman (April 2002). "Insulin-like growth factor-binding protein 5 (IGFBP-5) interacts with a four and a half LIM protein 2 (FHL2)". J. Biol. Chem. (United States) 277 (14): 12053–60. doi:10.1074/jbc.M110872200. ISSN 0021-9258. PMID 11821401. 
  16. ^ Bai, Shuting; Zha Jikun; Zhao Haibo; Ross F Patrick; Teitelbaum Steven L (November 2008). "Tumor Necrosis Factor Receptor-associated Factor 6 Is an Intranuclear Transcriptional Coactivator in Osteoclasts". J. Biol. Chem. (United States) 283 (45): 30861–7. doi:10.1074/jbc.M802525200. ISSN 0021-9258. PMC 2662164. PMID 18768464. 
  17. ^ Tanahashi, H; Tabira T (September 2000). "Alzheimer's disease-associated presenilin 2 interacts with DRAL, an LIM-domain protein". Hum. Mol. Genet. (ENGLAND) 9 (15): 2281–9. doi:10.1093/oxfordjournals.hmg.a018919. ISSN 0964-6906. PMID 11001931. 

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This article incorporates text from the United States National Library of Medicine, which is in the public domain.