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Four and a half LIM domains 2
Protein FHL2 PDB 1x4k.png
PDB rendering based on 1x4k.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols FHL2 ; AAG11; DRAL; FHL-2; SLIM-3; SLIM3
External IDs OMIM602633 MGI1338762 HomoloGene20372 GeneCards: FHL2 Gene
RNA expression pattern
PBB GE FHL2 202949 s at tn.png
More reference expression data
Species Human Mouse
Entrez 2274 14200
Ensembl ENSG00000115641 ENSMUSG00000008136
UniProt Q14192 O70433
RefSeq (mRNA) NM_001039492 NM_001289533
RefSeq (protein) NP_001034581 NP_001276462
Location (UCSC) Chr 2:
105.97 – 106.05 Mb
Chr 1:
43.12 – 43.16 Mb
PubMed search [1] [2]

Four and a half LIM domains protein 2 is a protein that in humans is encoded by the FHL2 gene.[1]


LIM proteins contain a highly conserved double zinc finger motif called the LIM domain.[supplied by OMIM][2]


FHL2 has been shown to interact with:


  1. ^ Morgan M, Madgwick A (October 1996). "Slim defines a novel family of LIM-proteins expressed in skeletal muscle". Biochem. Biophys. Res. Commun. 225 (2): 632–8. doi:10.1006/bbrc.1996.1222. PMID 8753811. 
  2. ^ "Entrez Gene: FHL2 four and a half LIM domains 2". 
  3. ^ Müller J, Isele U, Metzger E, Rempel A, Moser M, Pscherer A et al. (February 2000). "FHL2, a novel tissue-specific coactivator of the androgen receptor". EMBO J. 19 (3): 359–69. doi:10.1093/emboj/19.3.359. PMC 305573. PMID 10654935. 
  4. ^ Yan J, Zhu J, Zhong H, Lu Q, Huang C, Ye Q (October 2003). "BRCA1 interacts with FHL2 and enhances FHL2 transactivation function". FEBS Lett. 553 (1-2): 183–9. PMID 14550570. 
  5. ^ Yan J, Ye Q, Zhu J, Zhong H, Zheng H, Huang C (December 2003). "[Isolation and characterization of a BRCA1-interacting protein]". Yi Chuan Xue Bao 30 (12): 1161–6. PMID 14986435. 
  6. ^ Wei Y, Renard C, Labalette C, Wu Y, Lévy L, Neuveut C et al. (February 2003). "Identification of the LIM protein FHL2 as a coactivator of beta-catenin". J. Biol. Chem. 278 (7): 5188–94. doi:10.1074/jbc.M207216200. PMID 12466281. 
  7. ^ a b c d e Wixler V, Geerts D, Laplantine E, Westhoff D, Smyth N, Aumailley M et al. (October 2000). "The LIM-only protein DRAL/FHL2 binds to the cytoplasmic domain of several alpha and beta integrin chains and is recruited to adhesion complexes". J. Biol. Chem. 275 (43): 33669–78. doi:10.1074/jbc.M002519200. PMID 10906324. 
  8. ^ a b Fimia G, De Cesare D, Sassone-Corsi P (November 2000). "A family of LIM-only transcriptional coactivators: tissue-specific expression and selective activation of CREB and CREM". Mol. Cell. Biol. 20 (22): 8613–22. PMC 102166. PMID 11046156. 
  9. ^ Li H, Ng E, Lee S, Kotaka M, Tsui S, Lee C et al. (2001). "Protein-protein interaction of FHL3 with FHL2 and visualization of their interaction by green fluorescent proteins (GFP) two-fusion fluorescence resonance energy transfer (FRET)". J. Cell. Biochem. 80 (3): 293–303. PMID 11135358. 
  10. ^ Amaar Y, Thompson G, Linkhart T, Chen S, Baylink D, Mohan S (April 2002). "Insulin-like growth factor-binding protein 5 (IGFBP-5) interacts with a four and a half LIM protein 2 (FHL2)". J. Biol. Chem. 277 (14): 12053–60. doi:10.1074/jbc.M110872200. PMID 11821401. 
  11. ^ Samson T, Smyth N, Janetzky S, Wendler O, Müller J, Schüle R et al. (July 2004). "The LIM-only proteins FHL2 and FHL3 interact with alpha- and beta-subunits of the muscle alpha7beta1 integrin receptor". J. Biol. Chem. 279 (27): 28641–52. doi:10.1074/jbc.M312894200. PMID 15117962. 
  12. ^ Purcell N, Darwis D, Bueno O, Müller J, Schüle R, Molkentin J (February 2004). "Extracellular signal-regulated kinase 2 interacts with and is negatively regulated by the LIM-only protein FHL2 in cardiomyocytes". Mol. Cell. Biol. 24 (3): 1081–95. PMC 321437. PMID 14729955. 
  13. ^ Tanahashi H, Tabira T (September 2000). "Alzheimer's disease-associated presenilin 2 interacts with DRAL, an LIM-domain protein". Hum. Mol. Genet. 9 (15): 2281–9. PMID 11001931. 
  14. ^ Bai S, Zha J, Zhao H, Ross F, Teitelbaum S (November 2008). "Tumor necrosis factor receptor-associated factor 6 is an intranuclear transcriptional coactivator in osteoclasts". J. Biol. Chem. 283 (45): 30861–7. doi:10.1074/jbc.M802525200. PMC 2662164. PMID 18768464. 
  15. ^ Lange S, Auerbach D, McLoughlin P, Perriard E, Schäfer B, Perriard J et al. (December 2002). "Subcellular targeting of metabolic enzymes to titin in heart muscle may be mediated by DRAL/FHL-2". J. Cell. Sci. 115 (Pt 24): 4925–36. PMID 12432079. 
  16. ^ Ng E, Chan K, Wong C, Tsui S, Ngai S, Lee S et al. (2002). "Interaction of the heart-specific LIM domain protein, FHL2, with DNA-binding nuclear protein, hNP220". J. Cell. Biochem. 84 (3): 556–66. PMID 11813260. 
  17. ^ McLoughlin P, Ehler E, Carlile G, Licht J, Schäfer B (October 2002). "The LIM-only protein DRAL/FHL2 interacts with and is a corepressor for the promyelocytic leukemia zinc finger protein". J. Biol. Chem. 277 (40): 37045–53. doi:10.1074/jbc.M203336200. PMID 12145280. 

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This article incorporates text from the United States National Library of Medicine, which is in the public domain.