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Four and a half LIM domains 2
Protein FHL2 PDB 1x4k.png
PDB rendering based on 1x4k.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols FHL2 ; AAG11; DRAL; FHL-2; SLIM-3; SLIM3
External IDs OMIM602633 MGI1338762 HomoloGene20372 GeneCards: FHL2 Gene
RNA expression pattern
PBB GE FHL2 202949 s at tn.png
More reference expression data
Species Human Mouse
Entrez 2274 14200
Ensembl ENSG00000115641 ENSMUSG00000008136
UniProt Q14192 O70433
RefSeq (mRNA) NM_001039492 NM_001289533
RefSeq (protein) NP_001034581 NP_001276462
Location (UCSC) Chr 2:
105.97 – 106.05 Mb
Chr 1:
43.12 – 43.16 Mb
PubMed search [1] [2]

Four and a half LIM domains protein 2 is a protein that in humans is encoded by the FHL2 gene.[1]


LIM proteins contain a highly conserved double zinc finger motif called the LIM domain.[supplied by OMIM][2]


FHL2 has been shown to interact with:


  1. ^ Morgan MJ, Madgwick AJ (October 1996). "Slim defines a novel family of LIM-proteins expressed in skeletal muscle". Biochem. Biophys. Res. Commun. 225 (2): 632–8. doi:10.1006/bbrc.1996.1222. PMID 8753811. 
  2. ^ "Entrez Gene: FHL2 four and a half LIM domains 2". 
  3. ^ Müller JM, Isele U, Metzger E, Rempel A, Moser M, Pscherer A et al. (February 2000). "FHL2, a novel tissue-specific coactivator of the androgen receptor". EMBO J. 19 (3): 359–69. doi:10.1093/emboj/19.3.359. PMC 305573. PMID 10654935.  Vancouver style error (help)
  4. ^ Yan J, Zhu J, Zhong H, Lu Q, Huang C, Ye Q (October 2003). "BRCA1 interacts with FHL2 and enhances FHL2 transactivation function". FEBS Lett. 553 (1-2): 183–9. doi:10.1016/s0014-5793(03)00978-5. PMID 14550570. 
  5. ^ Yan JH, Ye QN, Zhu JH, Zhong HJ, Zheng HY, Huang CF (December 2003). "[Isolation and characterization of a BRCA1-interacting protein]". Yi Chuan Xue Bao 30 (12): 1161–6. PMID 14986435. 
  6. ^ Wei Y, Renard CA, Labalette C, Wu Y, Lévy L, Neuveut C et al. (February 2003). "Identification of the LIM protein FHL2 as a coactivator of beta-catenin". J. Biol. Chem. 278 (7): 5188–94. doi:10.1074/jbc.M207216200. PMID 12466281.  Vancouver style error (help)
  7. ^ a b c d e Wixler V, Geerts D, Laplantine E, Westhoff D, Smyth N, Aumailley M et al. (October 2000). "The LIM-only protein DRAL/FHL2 binds to the cytoplasmic domain of several alpha and beta integrin chains and is recruited to adhesion complexes". J. Biol. Chem. 275 (43): 33669–78. doi:10.1074/jbc.M002519200. PMID 10906324. 
  8. ^ a b Fimia GM, De Cesare D, Sassone-Corsi P (November 2000). "A family of LIM-only transcriptional coactivators: tissue-specific expression and selective activation of CREB and CREM". Mol. Cell. Biol. 20 (22): 8613–22. doi:10.1128/mcb.20.22.8613-8622.2000. PMC 102166. PMID 11046156. 
  9. ^ Li HY, Ng EK, Lee SM, Kotaka M, Tsui SK, Lee CY et al. (2001). "Protein-protein interaction of FHL3 with FHL2 and visualization of their interaction by green fluorescent proteins (GFP) two-fusion fluorescence resonance energy transfer (FRET)". J. Cell. Biochem. 80 (3): 293–303. doi:10.1002/1097-4644(20010301)80:3<293::aid-jcb10>3.3.co;2-l. PMID 11135358. 
  10. ^ Amaar YG, Thompson GR, Linkhart TA, Chen ST, Baylink DJ, Mohan S (April 2002). "Insulin-like growth factor-binding protein 5 (IGFBP-5) interacts with a four and a half LIM protein 2 (FHL2)". J. Biol. Chem. 277 (14): 12053–60. doi:10.1074/jbc.M110872200. PMID 11821401. 
  11. ^ Samson T, Smyth N, Janetzky S, Wendler O, Müller JM, Schüle R et al. (July 2004). "The LIM-only proteins FHL2 and FHL3 interact with alpha- and beta-subunits of the muscle alpha7beta1 integrin receptor". J. Biol. Chem. 279 (27): 28641–52. doi:10.1074/jbc.M312894200. PMID 15117962.  Vancouver style error (help)
  12. ^ Purcell NH, Darwis D, Bueno OF, Müller JM, Schüle R, Molkentin JD (February 2004). "Extracellular signal-regulated kinase 2 interacts with and is negatively regulated by the LIM-only protein FHL2 in cardiomyocytes". Mol. Cell. Biol. 24 (3): 1081–95. doi:10.1128/mcb.24.3.1081-1095.2004. PMC 321437. PMID 14729955.  Vancouver style error (help)
  13. ^ Tanahashi H, Tabira T (September 2000). "Alzheimer's disease-associated presenilin 2 interacts with DRAL, an LIM-domain protein". Hum. Mol. Genet. 9 (15): 2281–9. doi:10.1093/oxfordjournals.hmg.a018919. PMID 11001931. 
  14. ^ Bai S, Zha J, Zhao H, Ross FP, Teitelbaum SL (November 2008). "Tumor necrosis factor receptor-associated factor 6 is an intranuclear transcriptional coactivator in osteoclasts". J. Biol. Chem. 283 (45): 30861–7. doi:10.1074/jbc.M802525200. PMC 2662164. PMID 18768464. 
  15. ^ Lange S, Auerbach D, McLoughlin P, Perriard E, Schäfer BW, Perriard JC et al. (December 2002). "Subcellular targeting of metabolic enzymes to titin in heart muscle may be mediated by DRAL/FHL-2". J. Cell. Sci. 115 (Pt 24): 4925–36. doi:10.1242/jcs.00181. PMID 12432079.  Vancouver style error (help)
  16. ^ Ng EK, Chan KK, Wong CH, Tsui SK, Ngai SM, Lee SM et al. (2002). "Interaction of the heart-specific LIM domain protein, FHL2, with DNA-binding nuclear protein, hNP220". J. Cell. Biochem. 84 (3): 556–66. doi:10.1002/jcb.10041.abs. PMID 11813260. 
  17. ^ McLoughlin P, Ehler E, Carlile G, Licht JD, Schäfer BW (October 2002). "The LIM-only protein DRAL/FHL2 interacts with and is a corepressor for the promyelocytic leukemia zinc finger protein". J. Biol. Chem. 277 (40): 37045–53. doi:10.1074/jbc.M203336200. PMID 12145280.  Vancouver style error (help)

Further reading[edit]

External links[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.