FKBP1B

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FK506 binding protein 1B, 12.6 kDa
Protein FKBP1B PDB 1c9h.png
PDB rendering based on 1c9h.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols FKBP1B ; FKBP12.6; FKBP1L; OTK4; PKBP1L; PPIase
External IDs OMIM600620 MGI1336205 HomoloGene68380 ChEMBL: 2430 GeneCards: FKBP1B Gene
EC number 5.2.1.8
RNA expression pattern
PBB GE FKBP1B 206857 s at tn.png
PBB GE FKBP1B 209931 s at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 2281 14226
Ensembl ENSG00000119782 ENSMUSG00000020635
UniProt P68106 Q9Z2I2
RefSeq (mRNA) NM_004116 NM_016863
RefSeq (protein) NP_004107 NP_058559
Location (UCSC) Chr 2:
24.27 – 24.29 Mb
Chr 12:
4.83 – 4.84 Mb
PubMed search [1] [2]

Peptidyl-prolyl cis-trans isomerase FKBP1B is an enzyme that in humans is encoded by the FKBP1B gene.[1][2]

The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. This encoded protein is a cis-trans prolyl isomerase that binds the immunosuppressants FK506 (tacrolimus) and rapamycin (sirolimus). It is highly similar to the FK506-binding protein 1A. Its physiological role is thought to be in excitation-contraction coupling in cardiac muscle. There are two alternatively spliced transcript variants of this gene encoding different isoforms.[2]

References[edit]

  1. ^ Arakawa H, Nagase H, Hayashi N, Fujiwara T, Ogawa M, Shin S, Nakamura Y (Jun 1994). "Molecular cloning and expression of a novel human gene that is highly homologous to human FK506-binding protein 12kDa (hFKBP-12) and characterization of two alternatively spliced transcripts". Biochem Biophys Res Commun 200 (2): 836–43. doi:10.1006/bbrc.1994.1527. PMID 7513996. 
  2. ^ a b "Entrez Gene: FKBP1B FK506 binding protein 1B, 12.6 kDa". 

Further reading[edit]