FKBP2

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FK506 binding protein 2, 13kDa
Protein FKBP2 PDB 2pbc.png
PDB rendering based on 2pbc.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols FKBP2 ; FKBP-13; PPIase
External IDs OMIM186946 MGI95542 HomoloGene40604 GeneCards: FKBP2 Gene
EC number 5.2.1.8
RNA expression pattern
PBB GE FKBP2 203391 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 2286 14227
Ensembl ENSG00000173486 ENSMUSG00000056629
UniProt P26885 P45878
RefSeq (mRNA) NM_001135208 NM_001166368
RefSeq (protein) NP_001128680 NP_001159840
Location (UCSC) Chr 11:
64.01 – 64.01 Mb
Chr 19:
6.98 – 6.98 Mb
PubMed search [1] [2]

FK506-binding protein 2 is a protein that in humans is encoded by the FKBP2 gene.[1][2]

The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. This encoded protein is a cis-trans prolyl isomerase that binds the immunosuppressants FK506 and rapamycin. It is thought to function as an ER chaperone and may also act as a component of membrane cytoskeletal scaffolds. This gene has two alternatively spliced transcript variants that encode the same isoform. Multiple polyadenylation sites have been described for this gene, but the full length nature of this gene has not been determined.[2]

Interactions[edit]

FKBP2 has been shown to interact with ARFGEF1[3] and EPB41L2.[4]

References[edit]

  1. ^ Jin YJ, Albers MW, Lane WS, Bierer BE, Schreiber SL, Burakoff SJ (Sep 1991). "Molecular cloning of a membrane-associated human FK506- and rapamycin-binding protein, FKBP-13". Proc Natl Acad Sci U S A 88 (15): 6677–81. doi:10.1073/pnas.88.15.6677. PMC 52151. PMID 1713687. 
  2. ^ a b "Entrez Gene: FKBP2 FK506 binding protein 2, 13kDa". 
  3. ^ Padilla, Philip Ian; Chang Min-Ju, Pacheco-Rodriguez Gustavo, Adamik Ronald, Moss Joel, Vaughan Martha (Mar 2003). "Interaction of FK506-binding protein 13 with brefeldin A-inhibited guanine nucleotide-exchange protein 1 (BIG1): Effects of FK506". Proc. Natl. Acad. Sci. U.S.A. (United States) 100 (5): 2322–7. doi:10.1073/pnas.2628047100. ISSN 0027-8424. PMC 151339. PMID 12606707. 
  4. ^ Walensky, L D; Gascard P; Fields M E; Blackshaw S; Conboy J G; Mohandas N; Snyder S H (Apr 1998). "The 13-kD FK506 Binding Protein, FKBP13, Interacts with a Novel Homologue of the Erythrocyte Membrane Cytoskeletal Protein 4.1". J. Cell Biol. (UNITED STATES) 141 (1): 143–53. doi:10.1083/jcb.141.1.143. ISSN 0021-9525. PMC 2132710. PMID 9531554. 

Further reading[edit]