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FK506 binding protein 3, 25kDa
Protein FKBP3 PDB 1pbk.png
PDB rendering based on 1pbk.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols FKBP3 ; FKBP-25; FKBP-3; FKBP25; PPIase
External IDs OMIM186947 MGI1353460 HomoloGene1525 ChEMBL: 4746 GeneCards: FKBP3 Gene
EC number
RNA expression pattern
PBB GE FKBP3 218003 s at tn.png
More reference expression data
Species Human Mouse
Entrez 2287 30795
Ensembl ENSG00000100442 ENSMUSG00000020949
UniProt Q00688 Q62446
RefSeq (mRNA) NM_002013 NM_013902
RefSeq (protein) NP_002004 NP_038930
Location (UCSC) Chr 14:
45.58 – 45.6 Mb
Chr 12:
65.06 – 65.07 Mb
PubMed search [1] [2]

FK506-binding protein 3 is a protein that in humans is encoded by the FKBP3 gene.[1][2][3]

The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. This encoded protein is a cis-trans prolyl isomerase that binds the immunosuppressants FK506 and rapamycin. It has a higher affinity for rapamycin than for FK506 and thus may be an important target molecule for immunosuppression by rapamycin.[3]


FKBP3 has been shown to interact with YY1,[4] HDAC1,[4] Histone deacetylase 2[4] and Mdm2.[5]


  1. ^ Hung DT, Schreiber SL (Jun 1992). "cDNA cloning of a human 25 kDa FK506 and rapamycin binding protein". Biochem Biophys Res Commun 184 (2): 733–8. doi:10.1016/0006-291X(92)90651-Z. PMID 1374240. 
  2. ^ Porat R, Poutsiaka DD, Miller LC, Granowitz EV, Dinarello CA (May 1992). "Interleukin-1 (IL-1) receptor blockade reduces endotoxin and Borrelia burgdorferi-stimulated IL-8 synthesis in human mononuclear cells". FASEB J 6 (7): 2482–6. PMID 1532945. 
  3. ^ a b "Entrez Gene: FKBP3 FK506 binding protein 3, 25kDa". 
  4. ^ a b c Yang, W M; Yao Y L; Seto E (Sep 2001). "The FK506-binding protein 25 functionally associates with histone deacetylases and with transcription factor YY1". EMBO J. (England) 20 (17): 4814–25. doi:10.1093/emboj/20.17.4814. ISSN 0261-4189. PMC 125595. PMID 11532945. 
  5. ^ Ochocka, Anna Maria; Kampanis Petros, Nicol Samantha, Allende-Vega Nerea, Cox Miranda, Marcar Lynnette, Milne Diane, Fuller-Pace Frances, Meek David (Feb 2009). "FKBP25, a novel regulator of the p53 pathway, induces the degradation of MDM2 and activation of p53". FEBS Lett. (Netherlands) 583 (4): 621–6. doi:10.1016/j.febslet.2009.01.009. PMID 19166840. 

Further reading[edit]