FKBP52

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FK506 binding protein 4, 59kDa
Protein FKBP4 PDB 1n1a.png
PDB rendering based on 1n1a.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols FKBP4 ; FKBP51; FKBP52; FKBP59; HBI; Hsp56; PPIase; p52
External IDs OMIM600611 MGI95543 HomoloGene36085 ChEMBL: 4050 GeneCards: FKBP4 Gene
EC number 5.2.1.8
RNA expression pattern
PBB GE FKBP4 200895 s at tn.png
PBB GE FKBP4 200894 s at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 2288 14228
Ensembl ENSG00000004478 ENSMUSG00000030357
UniProt Q02790 P30416
RefSeq (mRNA) NM_002014 NM_010219
RefSeq (protein) NP_002005 NP_034349
Location (UCSC) Chr 12:
2.9 – 2.91 Mb
Chr 6:
128.43 – 128.44 Mb
PubMed search [1] [2]

FK506-binding protein 4 is a protein that in humans is encoded by the FKBP4 gene.[1][2]

The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. This encoded protein is a cis-trans prolyl isomerase that binds to the immunosuppressants FK506 and rapamycin. It has high structural and functional similarity to FK506-binding protein 1A (FKBP1A), but unlike FKBP1A, this protein does not have immunosuppressant activity when complexed with FK506. It interacts with interferon regulatory factor-4 and plays an important role in immunoregulatory gene expression in B and T lymphocytes. This encoded protein is known to associate with phytanoyl-CoA alpha-hydroxylase. It can also associate with two heat shock proteins (hsp90 and hsp70) and thus may play a role in the intracellular trafficking of hetero-oligomeric forms of the steroid hormone receptors. This protein correlates strongly with adeno-associated virus type 2 vectors (AAV) resulting in a significant increase in AAV-mediated transgene expression in human cell lines. Thus this encoded protein is thought to have important implications for the optimal use of AAV vectors in human gene therapy. This gene has been found to have multiple polyadenylation sites.[2]

This protein contains TPR repeats and has a PPlase domain.

Recent research suggests that FKBP52 may play a role in preventing the Tau protein from turning pathogenic. This may prove significant for the development of new Alzheimer’s drugs and for detecting the disease before the onset of clinical symptoms.

Interactions[edit]

FKBP52 has been shown to interact with GLMN.[3][4]

See also[edit]

References[edit]

  1. ^ Peattie DA, Harding MW, Fleming MA, DeCenzo MT, Lippke JA, Livingston DJ, Benasutti M (Dec 1992). "Expression and characterization of human FKBP52, an immunophilin that associates with the 90-kDa heat shock protein and is a component of steroid receptor complexes". Proc Natl Acad Sci U S A 89 (22): 10974–8. doi:10.1073/pnas.89.22.10974. PMC 50465. PMID 1279700. 
  2. ^ a b "Entrez Gene: FKBP4 FK506 binding protein 4, 59kDa". 
  3. ^ Chambraud, B; Radanyi C; Camonis J H; Shazand K; Rajkowski K; Baulieu E E (Dec 1996). "FAP48, a new protein that forms specific complexes with both immunophilins FKBP59 and FKBP12. Prevention by the immunosuppressant drugs FK506 and rapamycin". J. Biol. Chem. (UNITED STATES) 271 (51): 32923–9. doi:10.1074/jbc.271.51.32923. ISSN 0021-9258. PMID 8955134. 
  4. ^ Neye, H (Mar 2001). "Mutation of FKBP associated protein 48 (FAP48) at proline 219 disrupts the interaction with FKBP12 and FKBP52". Regul. Pept. (Netherlands) 97 (2–3): 147–52. doi:10.1016/S0167-0115(00)00206-8. ISSN 0167-0115. PMID 11164950. 

Further reading[edit]


External links[edit]