FKBP5

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FK506 binding protein 5
Protein FKBP5 PDB 1kt0.png
PDB rendering based on 1kt0.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols FKBP5 ; AIG6; FKBP51; FKBP54; P54; PPIase; Ptg-10
External IDs OMIM602623 MGI104670 HomoloGene3038 GeneCards: FKBP5 Gene
EC number 5.2.1.8
RNA expression pattern
PBB GE FKBP5 204560 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 2289 14229
Ensembl ENSG00000096060 ENSMUSG00000024222
UniProt Q13451 Q64378
RefSeq (mRNA) NM_001145775 NM_010220
RefSeq (protein) NP_001139247 NP_034350
Location (UCSC) Chr 6:
35.54 – 35.7 Mb
Chr 17:
28.4 – 28.52 Mb
PubMed search [1] [2]

FK506 binding protein 5, also known as FKBP5, is a protein which in humans is encoded by the FKBP5 gene.[1]

Function[edit]

The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. This encoded protein is a cis-trans prolyl isomerase that binds to the immunosuppressants FK506 and rapamycin. It is thought to mediate calcineurin inhibition. It also interacts functionally with mature corticoid receptor hetero-complexes (i.e. progesterone-, glucocorticoid-, mineralcorticoid-receptor complexes) along with the 90 kDa heat shock protein and P23 protein.

Clinical significance[edit]

Genetic studies have identified a role for FKBP5 in posttraumatic stress disorder, depression and anxiety.[2] For example, single nucleotide polymorphisms (SNPs) in FKBP5 have been found to interact with childhood trauma to predict severity of adult posttraumatic stress disorder (PTSD).[3] These findings suggest that individuals with these SNPs who are abused as children are more susceptible to PTSD as adults. FKBP5 has also been found to be less expressed in individuals with current PTSD.[4] The FKBP5 gene has been found to have multiple polyadenylation sites[1] and is statistically associated with a higher rate of depressive disorders.[5]

Interactions[edit]

FKBP5 has been shown to interact with Heat shock protein 90kDa alpha (cytosolic), member A1.[6]

See also[edit]

References[edit]

  1. ^ a b "Entrez Gene: FKBP5 FK506 binding protein 5". 
  2. ^ http://www.psychologytoday.com/blog/mouse-man/200811/gene-anxiety-depression-and-posttraumatic-stress-disorder-fkbp5
  3. ^ Binder EB, Bradley RG, Liu W, et al. (2008). "Association of FKBP5 polymorphisms and childhood abuse with risk of posttraumatic stress disorder symptoms in adults". JAMA 299 (11): 1291–305. doi:10.1001/jama.299.11.1291. PMC 2441757. PMID 18349090. 
  4. ^ Yehuda R, Cai G, Golier JA, Sarapas C, Galea S, Ising M, Rein T, Schmeidler J, Müller-Myhsok B, Holsboer F, Buxbaum JD (2009). "Gene expression patterns associated with posttraumatic stress disorder following exposure to the World Trade Center attacks.". Biol Psychiatry 66 (7): 2009 Apr 24 [Epub ahead of print]. doi:10.1016/j.biopsych.2009.02.034. PMID 19393990. 
  5. ^ Binder EB, Salyakina D, Lichtner P, et al. (December 2004). "Polymorphisms in FKBP5 are associated with increased recurrence of depressive episodes and rapid response to antidepressant treatment". Nat. Genet. 36 (12): 1319–25. doi:10.1038/ng1479. PMID 15565110. 
  6. ^ Nair, S C; Rimerman R A; Toran E J; Chen S; Prapapanich V; Butts R N; Smith D F (Feb 1997). "Molecular cloning of human FKBP51 and comparisons of immunophilin interactions with Hsp90 and progesterone receptor". Mol. Cell. Biol. (UNITED STATES) 17 (2): 594–603. ISSN 0270-7306. PMC 231784. PMID 9001212. 

Further reading[edit]