FKBPL

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FK506 binding protein like
Identifiers
Symbols FKBPL ; DIR1; NG7; WISP39
External IDs MGI1932127 HomoloGene10529 GeneCards: FKBPL Gene
Orthologs
Species Human Mouse
Entrez 63943 56299
Ensembl ENSG00000204315 ENSMUSG00000033739
UniProt Q9UIM3 O35450
RefSeq (mRNA) NM_022110 NM_019873
RefSeq (protein) NP_071393 NP_063926
Location (UCSC) Chr 6:
32.1 – 32.1 Mb
Chr 17:
34.64 – 34.65 Mb
PubMed search [1] [2]

FK506-binding protein like, also known as FKBPL, is a protein that in humans is encoded by the FKBPL gene.[1]

Function[edit]

FKBPL has similarity to the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. The encoded protein is thought to have a potential role in the induced radioresistance. Also it appears to have some involvement in the control of the cell cycle.[2]

FKBPL is involved in cellular response to stress. It was first isolated in 1999 and was initially named DIR1.[3] It was later reclassified because of its homology to the FKBP family of proteins and was renamed FKBP-like (FKBPL). A separate study that found it to be involved in the stabilisation of newly synthesised p21 termed it Wisp39.[4]

It is known to interact with Hsp90, glucocorticoid receptor and dynamitin and may play a role in signalling, like other FKBPs.[5]

FKBPL has also been shown to influence estrogen receptor signalling and can have a determinant effect on response to the breast cancer drug tamoxifen.[6]

References[edit]

  1. ^ Robson TA, Lohrer H, Bailie JR, Hirst DG, Joiner MC, Arrand JE (February 1997). "Gene regulation by low-dose ionizing radiation in a normal human lung epithelial cell line". Biochem. Soc. Trans. 25 (1): 335–42. PMID 9056895. 
  2. ^ "Entrez Gene: FKBPL". 
  3. ^ Robson T, Joiner MC, Wilson GD, McCullough W, Price ME, Logan I, Jones H, McKeown SR, Hirst DG (November 1999). "A novel human stress response-related gene with a potential role in induced radioresistance". Radiat. Res. (Radiation Research, Vol. 152, No. 5) 152 (5): 451–61. doi:10.2307/3580140. JSTOR 3580140. PMID 10521921. 
  4. ^ Jascur T, Brickner H, Salles-Passador I, Barbier V, El Khissiin A, Smith B, Fotedar R, Fotedar A (January 2005). "Regulation of p21(WAF1/CIP1) stability by WISp39, a Hsp90 binding TPR protein". Mol. Cell 17 (2): 237–49. doi:10.1016/j.molcel.2004.11.049. PMID 15664193. 
  5. ^ McKeen HD, McAlpine K, Valentine A, Quinn DJ, McClelland K, Byrne C, O'Rourke M, Young S, Scott CJ, McCarthy HO, Hirst DG, Robson T (July 2008). "A novel FK506-like binding protein (FKBPL) interacts with the glucocorticoid receptor and regulates steroid receptor signalling". Endocrinology 149 (11): 5724–34. doi:10.1210/en.2008-0168. PMID 18669603. 
  6. ^ McKeen HD, Byrne C, Jithesh PV, Donley C, Valentine A, Yakkundi A, O'Rourke M, Swanton C, McCarthy HO, Hirst DG, Robson T (February 2010). "FKBPL regulates estrogen receptor signaling and determines response to endocrine therapy". Cancer Res. 70 (3): 1090–100. doi:10.1158/0008-5472.CAN-09-2515. PMID 20103631. 

This article incorporates text from the United States National Library of Medicine, which is in the public domain.