From Wikipedia, the free encyclopedia
Jump to: navigation, search
Fms-related tyrosine kinase 4
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols FLT4 ; FLT41; LMPH1A; PCL; VEGFR3
External IDs OMIM136352 MGI95561 HomoloGene7321 ChEMBL: 1955 GeneCards: FLT4 Gene
EC number
Species Human Mouse
Entrez 2324 14257
Ensembl ENSG00000037280 ENSMUSG00000020357
UniProt P35916 P35917
RefSeq (mRNA) NM_002020 NM_008029
RefSeq (protein) NP_002011 NP_032055
Location (UCSC) Chr 5:
180.03 – 180.08 Mb
Chr 11:
49.61 – 49.65 Mb
PubMed search [1] [2]

Fms-related tyrosine kinase 4, also known as FLT4, is a protein which in humans is encoded by the FLT4 gene.[1][2]

This gene encodes a tyrosine kinase receptor for vascular endothelial growth factors C and D. The protein is thought to be involved in lymphangiogenesis and maintenance of the lymphatic endothelium. Mutations in this gene cause hereditary lymphedema type IA.[1]


FLT4 has been shown to interact with SHC1.[3][4][5]

See also[edit]


  1. ^ a b "Entrez Gene: FLT4 fms-related tyrosine kinase 4". 
  2. ^ Galland F, Karamysheva A, Mattei MG, Rosnet O, Marchetto S, Birnbaum D (June 1992). "Chromosomal localization of FLT4, a novel receptor-type tyrosine kinase gene". Genomics 13 (2): 475–8. doi:10.1016/0888-7543(92)90277-Y. PMID 1319394. 
  3. ^ Pajusola, K; Aprelikova O; Pelicci G; Weich H; Claesson-Welsh L; Alitalo K (December 1994). "Signalling properties of FLT4, a proteolytically processed receptor tyrosine kinase related to two VEGF receptors". Oncogene (ENGLAND) 9 (12): 3545–55. ISSN 0950-9232. PMID 7970715. 
  4. ^ Fournier, E; Blaikie P; Rosnet O; Margolis B; Birnbaum D; Borg J P (January 1999). "Role of tyrosine residues and protein interaction domains of SHC adaptor in VEGF receptor 3 signaling". Oncogene (ENGLAND) 18 (2): 507–14. doi:10.1038/sj.onc.1202315. ISSN 0950-9232. PMID 9927207. 
  5. ^ Fournier, E; Rosnet O; Marchetto S; Turck C W; Rottapel R; Pelicci P G; Birnbaum D; Borg J P (May 1996). "Interaction with the phosphotyrosine binding domain/phosphotyrosine interacting domain of SHC is required for the transforming activity of the FLT4/VEGFR3 receptor tyrosine kinase". J. Biol. Chem. (UNITED STATES) 271 (22): 12956–63. doi:10.1074/jbc.271.22.12956. ISSN 0021-9258. PMID 8662748. 

External links[edit]

Further reading[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.