Flavin containing monooxygenase 1

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Flavin containing monooxygenase 1
Identifiers
Symbol FMO1
External IDs OMIM136130 MGI1310002 HomoloGene55520 GeneCards: FMO1 Gene
EC number 1.14.13.8
RNA expression pattern
PBB GE FMO1 205666 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 2326 14261
Ensembl ENSG00000010932 ENSMUSG00000040181
UniProt Q01740 P50285
RefSeq (mRNA) NM_001282692 NM_010231
RefSeq (protein) NP_001269621 NP_034361
Location (UCSC) Chr 1:
171.22 – 171.26 Mb
Chr 1:
162.83 – 162.87 Mb
PubMed search [1] [2]

Dimethylaniline monooxygenase [N-oxide-forming] 1 is an enzyme that in humans is encoded by the FMO1 gene.[1]

Metabolic N-oxidation of the diet-derived amino-trimethylamine (TMA) is mediated by flavin-containing monooxygenase and is subject to an inherited FMO3 polymorphism in humans resulting in a small subpopulation with reduced TMA N-oxidation capacity resulting in fish odor syndrome Trimethylaminuria. Three forms of the enzyme, FMO1 found in fetal liver, FMO2 found in adult liver, and FMO3 are encoded by genes clustered in the 1q23-q25 region. Flavin-containing monooxygenases are NADPH-dependent flavoenzymes that catalyzes the oxidation of soft nucleophilic heteroatom centers in xenobiotics such as pesticides and drugs.[1]

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