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Formin binding protein 1
Protein FNBP1 PDB 2efl.png
PDB rendering based on 2efl.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols FNBP1 ; FBP17
External IDs OMIM606191 MGI109606 HomoloGene100983 GeneCards: FNBP1 Gene
RNA expression pattern
PBB GE FNBP1 213940 s at tn.png
PBB GE FNBP1 212288 at tn.png
More reference expression data
Species Human Mouse
Entrez 23048 14269
Ensembl ENSG00000187239 ENSMUSG00000075415
UniProt Q96RU3 Q80TY0
RefSeq (mRNA) NM_015033 NM_001038700
RefSeq (protein) NP_055848 NP_001033789
Location (UCSC) Chr 9:
132.65 – 132.81 Mb
Chr 2:
31.03 – 31.14 Mb
PubMed search [1] [2]

Formin-binding protein 1 is a protein that in humans is encoded by the FNBP1 gene.[1][2][3]

The protein encoded by this gene is a member of the formin-binding-protein family. The protein contains an N-terminal Fer/Cdc42-interacting protein 4 (CIP4) homology (FCH) domain followed by a coiled-coil domain, a proline-rich motif, a second coiled-coil domain, a Rho family protein-binding domain (RBD), and a C-terminal SH3 domain. This protein binds sorting nexin 2 (SNX2), tankyrase (TNKS), and dynamin; an interaction between this protein and formin has not been demonstrated yet in human.[3]


FNBP1 has been shown to interact with SNX2,[2][4] DNM1,[5] TNKS,[4] Fas ligand[6] and AKAP9.[7]


  1. ^ Nagase T, Ishikawa K, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (Aug 1998). "Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro". DNA Res 5 (1): 31–9. doi:10.1093/dnares/5.1.31. PMID 9628581. 
  2. ^ a b Fuchs U, Rehkamp G, Haas OA, Slany R, Konig M, Bojesen S, Bohle RM, Damm-Welk C, Ludwig WD, Harbott J, Borkhardt A (Jul 2001). "The human formin-binding protein 17 (FBP17) interacts with sorting nexin, SNX2, and is an MLL-fusion partner in acute myelogeneous leukemia". Proc Natl Acad Sci U S A 98 (15): 8756–61. doi:10.1073/pnas.121433898. PMC 37508. PMID 11438682. 
  3. ^ a b "Entrez Gene: FNBP1 formin binding protein 1". 
  4. ^ a b Fuchs, U; Rehkamp G F; Slany R; Follo M; Borkhardt A (Nov 2003). "The formin-binding protein 17, FBP17, binds via a TNKS binding motif to tankyrase, a protein involved in telomere maintenance". FEBS Lett. (Netherlands) 554 (1–2): 10–6. doi:10.1016/S0014-5793(03)01063-9. ISSN 0014-5793. PMID 14596906. 
  5. ^ Kamioka, Yuji; Fukuhara Shigetomo; Sawa Hirofumi; Nagashima Kazuo; Masuda Michitaka; Matsuda Michiyuki; Mochizuki Naoki (Sep 2004). "A novel dynamin-associating molecule, formin-binding protein 17, induces tubular membrane invaginations and participates in endocytosis". J. Biol. Chem. (United States) 279 (38): 40091–9. doi:10.1074/jbc.M404899200. ISSN 0021-9258. PMID 15252009. 
  6. ^ Ghadimi, Markus Philipp; Sanzenbacher Ralf; Thiede Bernd; Wenzel Jennifer; Jing Qian; Plomann Markus; Borkhardt Arndt; Kabelitz Dieter; Janssen Ottmar (May 2002). "Identification of interaction partners of the cytosolic polyproline region of CD95 ligand (CD178)". FEBS Lett. (Netherlands) 519 (1–3): 50–8. doi:10.1016/S0014-5793(02)02709-6. ISSN 0014-5793. PMID 12023017. 
  7. ^ Larocca, M Cecilia; Shanks Ryan A; Tian Lan; Nelson David L; Stewart Donn M; Goldenring James R (Jun 2004). "AKAP350 Interaction with cdc42 Interacting Protein 4 at the Golgi Apparatus". Mol. Biol. Cell (United States) 15 (6): 2771–81. doi:10.1091/mbc.E03-10-0757. ISSN 1059-1524. PMC 420101. PMID 15047863. 

Further reading[edit]