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Forkhead box A3
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols FOXA3 ; FKHH3; HNF3G; TCF3G
External IDs OMIM602295 MGI1347477 HomoloGene3308 GeneCards: FOXA3 Gene
Species Human Mouse
Entrez 3171 15377
Ensembl ENSG00000170608 ENSMUSG00000040891
UniProt P55318 P35584
RefSeq (mRNA) NM_004497 NM_008260
RefSeq (protein) NP_004488 NP_032286
Location (UCSC) Chr 19:
46.37 – 46.38 Mb
Chr 7:
19.01 – 19.02 Mb
PubMed search [1] [2]

Hepatocyte nuclear factor 3-gamma (HNF-3G), also known as forkhead box protein A3 (FOXA3) or transcription factor 3G (TCF-3G) is a protein that in humans is encoded by the FOXA3 gene.[1][2]


HNF-3G is a member of the forkheadclass of DNA-binding proteins. These hepatocyte nuclear factors are transcriptional activators for liver-specific transcripts such as albumin and transthyretin, and they also interact with chromatin. Similar family members in mice have roles in the regulation of metabolism and in the differentiation of the pancreas and liver.[1]


  1. ^ a b "Entrez Gene: forkhead box A3". 
  2. ^ Mincheva A, Lichter P, Schütz G, Kaestner KH (February 1997). "Assignment of the human genes for hepatocyte nuclear factor 3-alpha, -beta, and -gamma (HNF3A, HNF3B, HNF3G) to 14q12-q13, 20p11, and 19q13.2-q13.4". Genomics 39 (3): 417–9. doi:10.1006/geno.1996.4477. PMID 9119385. 

Further reading[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.