FOXG1

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Forkhead box G1
Identifiers
Symbols FOXG1 ; BF1; BF2; FHKL3; FKH2; FKHL1; FKHL2; FKHL3; FKHL4; FOXG1A; FOXG1B; FOXG1C; HBF-1; HBF-2; HBF-3; HBF-G2; HBF2; HFK1; HFK2; HFK3; KHL2; QIN
External IDs OMIM164874 MGI1347464 HomoloGene3843 GeneCards: FOXG1 Gene
RNA expression pattern
PBB GE FOXG1B 206018 at tn.png
PBB GE FOXG1B 207658 s at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 2290 15228
Ensembl ENSG00000176165 ENSMUSG00000020950
UniProt P55316 Q60987
RefSeq (mRNA) NM_005249 NM_001160112
RefSeq (protein) NP_005240 NP_001153584
Location (UCSC) Chr 14:
29.24 – 29.24 Mb
Chr 12:
49.38 – 49.39 Mb
PubMed search [1] [2]

Forkhead box protein G1 is a protein that in humans is encoded by the FOXG1 gene.[1][2][3]



This gene belongs to the forkhead family of transcription factors which is characterized by a distinct forkhead domain. The specific function of this gene has not yet been determined; however, it may play a role in the development of the brain and telencephalon.[3]

Much more research is needed to understand the impacts and effects of mutations of this group of genes. There are currently some research studies on Fox g1 underway at the University of Rochester, and at Azienda Ospedaliera Universitaria Senese, Italy. At the close of 2012, The International Fox G1 Foundation was created, and is working to secure funding for the development of a research mouse. For more information, and to help in these efforts, please visit www.foxg1.com

See also[edit]

Interactions[edit]

FOXG1 has been shown to interact with JARID1B.[4]

References[edit]

  1. ^ Murphy DB, Wiese S, Burfeind P, Schmundt D, Mattei MG, Schulz-Schaeffer W, Thies U (Nov 1994). "Human brain factor 1, a new member of the fork head gene family". Genomics 21 (3): 551–7. doi:10.1006/geno.1994.1313. PMID 7959731. 
  2. ^ Bredenkamp N, Seoighe C, Illing N (Feb 2007). "Comparative evolutionary analysis of the FoxG1 transcription factor from diverse vertebrates identifies conserved recognition sites for microRNA regulation". Dev Genes Evol 217 (3): 227–33. doi:10.1007/s00427-006-0128-x. PMID 17260156. 
  3. ^ a b "Entrez Gene: FOXG1B forkhead box G1B". 
  4. ^ Tan, Keith; Shaw Anthony L, Madsen Bente, Jensen Kirsten, Taylor-Papadimitriou Joyce, Freemont Paul S (Jun 2003). "Human PLU-1 Has transcriptional repression properties and interacts with the developmental transcription factors BF-1 and PAX9". J. Biol. Chem. (United States) 278 (23): 20507–13. doi:10.1074/jbc.M301994200. ISSN 0021-9258. PMID 12657635. 

www.foxg1.com

Further reading[edit]

External links[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.