FOXH1

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Forkhead box H1
Identifiers
Symbols FOXH1 ; FAST-1; FAST1
External IDs OMIM603621 MGI1347465 HomoloGene2914 GeneCards: FOXH1 Gene
RNA expression pattern
PBB GE FOXH1 207644 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 8928 14106
Ensembl ENSG00000160973 ENSMUSG00000033837
UniProt O75593 O88621
RefSeq (mRNA) NM_003923 NM_007989
RefSeq (protein) NP_003914 NP_032015
Location (UCSC) Chr 8:
145.7 – 145.7 Mb
Chr 15:
76.67 – 76.67 Mb
PubMed search [1] [2]

Forkhead box protein H1 is a protein that in humans is encoded by the FOXH1 gene.[1][2]

FOXH1 encodes a human homolog of Xenopus forkhead activin signal transducer-1. FOXH1 protein binds SMAD2 and activates an activin response element via binding the DNA motif TGT(G/T)(T/G)ATT.[2]

See also[edit]

Interactions[edit]

FOXH1 has been shown to interact with DRAP1[3] and Mothers against decapentaplegic homolog 2.[4][5][6][7][8]

References[edit]

  1. ^ Zhou S, Zawel L, Lengauer C, Kinzler KW, Vogelstein B (August 1998). "Characterization of human FAST-1, a TGF beta and activin signal transducer". Mol Cell 2 (1): 121–7. doi:10.1016/S1097-2765(00)80120-3. PMID 9702198. 
  2. ^ a b "Entrez Gene: FOXH1 forkhead box H1". 
  3. ^ Iratni, Rabah; Yan Yu-Ting, Chen Canhe, Ding Jixiang, Zhang Yi, Price Sandy M, Reinberg Danny, Shen Michael M (December 2002). "Inhibition of excess nodal signaling during mouse gastrulation by the transcriptional corepressor DRAP1". Science (United States) 298 (5600): 1996–9. doi:10.1126/science.1073405. PMID 12471260. 
  4. ^ Wotton, D; Lo R S, Lee S, Massagué J (April 1999). "A Smad transcriptional corepressor". Cell (UNITED STATES) 97 (1): 29–39. doi:10.1016/S0092-8674(00)80712-6. ISSN 0092-8674. PMID 10199400. 
  5. ^ Liu, B; Dou C L, Prabhu L, Lai E (January 1999). "FAST-2 is a mammalian winged-helix protein which mediates transforming growth factor beta signals". Mol. Cell. Biol. (UNITED STATES) 19 (1): 424–30. ISSN 0270-7306. PMC 83900. PMID 9858566. 
  6. ^ Liu, F; Pouponnot C, Massagué J (December 1997). "Dual role of the Smad4/DPC4 tumor suppressor in TGFbeta-inducible transcriptional complexes". Genes Dev. (UNITED STATES) 11 (23): 3157–67. doi:10.1101/gad.11.23.3157. ISSN 0890-9369. PMC 316747. PMID 9389648. 
  7. ^ Dou, C; Lee J, Liu B, Liu F, Massague J, Xuan S, Lai E (September 2000). "BF-1 interferes with transforming growth factor beta signaling by associating with Smad partners". Mol. Cell. Biol. (UNITED STATES) 20 (17): 6201–11. doi:10.1128/MCB.20.17.6201-6211.2000. ISSN 0270-7306. PMC 86095. PMID 10938097. 
  8. ^ Chen, X; Weisberg E, Fridmacher V, Watanabe M, Naco G, Whitman M (September 1997). "Smad4 and FAST-1 in the assembly of activin-responsive factor". Nature (ENGLAND) 389 (6646): 85–9. doi:10.1038/38008. ISSN 0028-0836. PMID 9288972. 

Further reading[edit]

External links[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.