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Forkhead box H1
Symbols FOXH1 ; FAST-1; FAST1
External IDs OMIM603621 MGI1347465 HomoloGene2914 GeneCards: FOXH1 Gene
RNA expression pattern
PBB GE FOXH1 207644 at tn.png
More reference expression data
Species Human Mouse
Entrez 8928 14106
Ensembl ENSG00000160973 ENSMUSG00000033837
UniProt O75593 O88621
RefSeq (mRNA) NM_003923 NM_007989
RefSeq (protein) NP_003914 NP_032015
Location (UCSC) Chr 8:
145.7 – 145.7 Mb
Chr 15:
76.67 – 76.67 Mb
PubMed search [1] [2]

Forkhead box protein H1 is a protein that in humans is encoded by the FOXH1 gene.[1][2]


FOXH1 encodes a human homolog of Xenopus forkhead activin signal transducer-1. FOXH1 protein binds SMAD2 and activates an activin response element via binding the DNA motif TGT(G/T)(T/G)ATT.[2]


FOXH1 has been shown to interact with DRAP1[3] and Mothers against decapentaplegic homolog 2.[4][5][6][7][8]

See also[edit]


  1. ^ Zhou S, Zawel L, Lengauer C, Kinzler K, Vogelstein B (August 1998). "Characterization of human FAST-1, a TGF beta and activin signal transducer". Mol Cell 2 (1): 121–7. doi:10.1016/S1097-2765(00)80120-3. PMID 9702198. 
  2. ^ a b "Entrez Gene: FOXH1 forkhead box H1". 
  3. ^ Iratni R, Yan Y, Chen C, Ding J, Zhang Y, Price S et al. (December 2002). "Inhibition of excess nodal signaling during mouse gastrulation by the transcriptional corepressor DRAP1". Science 298 (5600): 1996–9. doi:10.1126/science.1073405. PMID 12471260. 
  4. ^ Wotton D, Lo R, Lee S, Massagué J (April 1999). "A Smad transcriptional corepressor". Cell 97 (1): 29–39. doi:10.1016/S0092-8674(00)80712-6. PMID 10199400. 
  5. ^ Liu B, Dou C, Prabhu L, Lai E (January 1999). "FAST-2 is a mammalian winged-helix protein which mediates transforming growth factor beta signals". Mol. Cell. Biol. 19 (1): 424–30. PMC 83900. PMID 9858566. 
  6. ^ Liu F, Pouponnot C, Massagué J (December 1997). "Dual role of the Smad4/DPC4 tumor suppressor in TGFbeta-inducible transcriptional complexes". Genes Dev. 11 (23): 3157–67. doi:10.1101/gad.11.23.3157. PMC 316747. PMID 9389648. 
  7. ^ Dou C, Lee J, Liu B, Liu F, Massague J, Xuan S et al. (September 2000). "BF-1 interferes with transforming growth factor beta signaling by associating with Smad partners". Mol. Cell. Biol. 20 (17): 6201–11. doi:10.1128/MCB.20.17.6201-6211.2000. PMC 86095. PMID 10938097. 
  8. ^ Chen X, Weisberg E, Fridmacher V, Watanabe M, Naco G, Whitman M (September 1997). "Smad4 and FAST-1 in the assembly of activin-responsive factor". Nature 389 (6646): 85–9. doi:10.1038/38008. PMID 9288972. 

Further reading[edit]

External links[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.