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Forkhead box N1
Symbols FOXN1 ; FKHL20; RONU; WHN
External IDs OMIM600838 MGI102949 HomoloGene2664 GeneCards: FOXN1 Gene
RNA expression pattern
PBB GE FOXN1 207683 at tn.png
More reference expression data
Species Human Mouse
Entrez 8456 15218
Ensembl ENSG00000109101 ENSMUSG00000002057
UniProt O15353 Q61575
RefSeq (mRNA) NM_003593 NM_001277290
RefSeq (protein) NP_003584 NP_001264219
Location (UCSC) Chr 17:
26.83 – 26.87 Mb
Chr 11:
78.36 – 78.39 Mb
PubMed search [1] [2]

Forkhead box protein N1 is a protein that in humans is encoded by the FOXN1 gene.[1][2]

Mutations in the winged-helix transcription factor gene at the nude locus in mice and rats produce the pleiotropic phenotype of hairlessness and athymia, resulting in a severely compromised immune system. This gene is orthologous to the mouse and rat genes and encodes a similar DNA-binding transcription factor that is thought to regulate keratin gene expression. A mutation in this gene has been correlated with T-cell immunodeficiency, the skin disorder congenital alopecia, and nail dystrophy. Alternative splicing in the 5' UTR of this gene has been observed.[2]


  1. ^ Schorpp M, Hofmann M, Dear TN, Boehm T (Dec 1997). "Characterization of mouse and human nude genes". Immunogenetics 46 (6): 509–15. doi:10.1007/s002510050312. PMID 9321431. 
  2. ^ a b "Entrez Gene: FOXN1 forkhead box N1". 

Further reading[edit]