Forkhead box protein N1 is a protein that in humans is encoded by the FOXN1gene.
Mutations in the winged-helix transcription factor gene at the nude locus in mice and rats produce the pleiotropic phenotype of hairlessness and athymia, resulting in a severely compromised immune system. This gene is orthologous to the mouse and rat genes and encodes a similar DNA-binding transcription factor that is thought to regulate keratin gene expression. A mutation in this gene has been correlated with T-cell immunodeficiency, the skin disorder congenital alopecia, and nail dystrophy. Alternative splicing in the 5' UTR of this gene has been observed.
Adriani M, Martinez-Mir A, Fusco F, et al. (2004). "Ancestral founder mutation of the nude (FOXN1) gene in congenital severe combined immunodeficiency associated with alopecia in southern Italy population". Ann. Hum. Genet.68 (Pt 3): 265–8. doi:10.1046/j.1529-8817.2004.00091.x. PMID15180707.
Janes SM, Ofstad TA, Campbell DH, et al. (2005). "Transient activation of FOXN1 in keratinocytes induces a transcriptional programme that promotes terminal differentiation: contrasting roles of FOXN1 and Akt". J. Cell. Sci.117 (Pt 18): 4157–68. doi:10.1242/jcs.01302. PMID15316080.
Nonaka D, Henley JD, Chiriboga L, Yee H (2007). "Diagnostic utility of thymic epithelial markers CD205 (DEC205) and Foxn1 in thymic epithelial neoplasms". Am. J. Surg. Pathol.31 (7): 1038–44. doi:10.1097/PAS.0b013e31802b4917. PMID17592270.