FOXN1

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Forkhead box N1
Identifiers
Symbols FOXN1 ; FKHL20; RONU; WHN
External IDs OMIM600838 MGI102949 HomoloGene2664 GeneCards: FOXN1 Gene
RNA expression pattern
PBB GE FOXN1 207683 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 8456 15218
Ensembl ENSG00000109101 ENSMUSG00000002057
UniProt O15353 Q61575
RefSeq (mRNA) NM_003593 NM_001277290
RefSeq (protein) NP_003584 NP_001264219
Location (UCSC) Chr 17:
26.83 – 26.87 Mb
Chr 11:
78.36 – 78.39 Mb
PubMed search [1] [2]

Forkhead box protein N1 is a protein that in humans is encoded by the FOXN1 gene.[1][2]

Mutations in the winged-helix transcription factor gene at the nude locus in mice and rats produce the pleiotropic phenotype of hairlessness and athymia, resulting in a severely compromised immune system. This gene is orthologous to the mouse and rat genes and encodes a similar DNA-binding transcription factor that is thought to regulate keratin gene expression. A mutation in this gene has been correlated with T-cell immunodeficiency, the skin disorder congenital alopecia, and nail dystrophy. Alternative splicing in the 5' UTR of this gene has been observed.[2]

References[edit]

  1. ^ Schorpp M, Hofmann M, Dear TN, Boehm T (Dec 1997). "Characterization of mouse and human nude genes". Immunogenetics 46 (6): 509–15. doi:10.1007/s002510050312. PMID 9321431. 
  2. ^ a b "Entrez Gene: FOXN1 forkhead box N1". 

Further reading[edit]