FREM2

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FRAS1 related extracellular matrix protein 2
Identifiers
Symbols FREM2 ; DKFZp686J0811; DKFZp781I048; KIAA1074
External IDs OMIM608945 MGI2444465 HomoloGene18454 GeneCards: FREM2 Gene
RNA expression pattern
PBB GE FREM2 gnf1h02739 at tn.png
PBB GE FREM2 gnf1h07842 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 341640 242022
Ensembl ENSG00000150893 ENSMUSG00000037016
UniProt Q5SZK8 Q6NVD0
RefSeq (mRNA) NM_207361 NM_172862
RefSeq (protein) NP_997244 NP_766450
Location (UCSC) Chr 13:
39.26 – 39.46 Mb
Chr 3:
53.51 – 53.66 Mb
PubMed search [1] [2]

FRAS1-related extracellular matrix protein 2 is a protein that in humans is encoded by the FREM2 gene.[1][2]

This gene encodes a membrane protein that belongs to the FRAS1 family. This extracellular matrix protein is thought to be required for maintaining the integrity of the skin epithelium and the differentiated state of renal epithelia. The protein localizes to the basement membrane, forming a ternary complex that plays a role in epidermal-dermal interactions during morphogenetic processes. Mutations in this gene are associated with Fraser syndrome.[2]

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