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FERM domain containing 6
Symbols FRMD6 ; C14orf31; EX1; Willin; c14_5320
External IDs OMIM614555 MGI2442579 HomoloGene12449 GeneCards: FRMD6 Gene
Species Human Mouse
Entrez 122786 319710
Ensembl ENSG00000139926 ENSMUSG00000048285
UniProt Q96NE9 Q8C0V9
RefSeq (mRNA) NM_001042481 NM_028127
RefSeq (protein) NP_001035946 NP_082403
Location (UCSC) Chr 14:
51.96 – 52.2 Mb
Chr 12:
70.83 – 70.9 Mb
PubMed search [1] [2]

FERM domain-containing protein 6 is a protein that in humans is encoded by the FRMD6 gene.[1]


Further reading[edit]

  • Moleirinho S, Patrick C, Tilston-Lünel AM, Higginson JR, Angus L, Antkowiak M, Barnett SC, Prystowsky MB, Reynolds PA, Gunn-Moore FJ. (2013) Willin, an Upstream Component of the Hippo Signaling Pathway, Orchestrates Mammalian Peripheral Nerve Fibroblasts. PLoS One 8(4) e60028 PMID 23593160
  • Angus L, Moleirinho S, Herron L, Sinha A, Zhang X, Niestrata M, Dholakia K, Prystowsky MB, Harvey KF, Reynolds PA & Gunn-Moore FJ. (2012). "Willin/FRMD6 expression activates the Hippo signaling pathway kinases in mammals and antagonizes oncogenic YAP.". Oncogene 31 (2): 238–250. doi:10.1038/onc.2011.224. PMID 21666719. PMID 21666719
  • Madan R., Brandwein-Gensler M., Schlecht NF., Elias, K., Gorbovitsky, E., Belbin, TJ., Mahood, R., Breining, D., Qian, H., Childs G., Locker J., Smith R., Haigentz Jr M., Gunn-Moore F. & Prystowsky MB. (2006). "Cytoplasmic ezrin has prognostic significance for head and neck squamous cell carcinoma". Head and Neck 28 (11): 1018–1027. doi:10.1002/hed.20435. PMID 16783828. 
  • Hamaratoglu F; Willecke M; Kango-Singh M et al. (2006). "The tumour-suppressor genes NF2/Merlin and Expanded act through Hippo signalling to regulate cell proliferation and apoptosis". Nat. Cell Biol. 8 (1): 27–36. doi:10.1038/ncb1339. PMID 16341207. 
  • Rual JF; Venkatesan K; Hao T et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–1178. doi:10.1038/nature04209. PMID 16189514. 
  • Gunn-Moore FJ; Welsh GI; Herron LR et al. (2005). "A novel 4.1 ezrin radixin moesin (FERM)-containing protein, 'Willin'". FEBS Lett. 579 (22): 5089–5094. doi:10.1016/j.febslet.2005.07.097. PMID 16137681. 
  • Gerhard DS; Wagner L; Feingold EA et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–2127. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. 
  • Jin J; Smith FD; Stark C et al. (2004). "Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization". Curr. Biol. 14 (16): 1436–1450. doi:10.1016/j.cub.2004.07.051. PMID 15324660. 
  • Ota T; Suzuki Y; Nishikawa T et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–45. doi:10.1038/ng1285. PMID 14702039. 
  • Heilig R; Eckenberg R; Petit JL et al. (2003). "The DNA sequence and analysis of human chromosome 14". Nature 421 (6923): 601–607. doi:10.1038/nature01348. PMID 12508121. 
  • Strausberg RL; Feingold EA; Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–16903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.