FRS2

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Fibroblast growth factor receptor substrate 2
Protein FRS2 PDB 1xr0.png
PDB rendering based on 1xr0.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols FRS2 ; FRS2A; FRS2alpha; SNT; SNT-1; SNT1
External IDs OMIM607743 MGI1100860 HomoloGene4846 GeneCards: FRS2 Gene
RNA expression pattern
PBB GE FRS2 221308 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 10818 327826
Ensembl ENSG00000166225 ENSMUSG00000020170
UniProt Q8WU20 Q8C180
RefSeq (mRNA) NM_001042555 NM_177798
RefSeq (protein) NP_001036020 NP_808466
Location (UCSC) Chr 12:
69.86 – 69.97 Mb
Chr 10:
117.07 – 117.15 Mb
PubMed search [1] [2]

Fibroblast growth factor receptor substrate 2 is a protein that in humans is encoded by the FRS2 gene.[1][2][3]

FRS2 is overexpressed and amplified in several cancer types, including prostate cancer.[4][5]


Interactions[edit]

FRS2 has been shown to interact with PRKCI,[6] Grb2,[7][8][9][10] PTPN11,[11][12][13] Fibroblast growth factor receptor 1,[2][14][15][16] TrkA,[9] Cbl gene[8] and SOS1.[8][10][17]

References[edit]

  1. ^ Wang JK, Xu H, Li HC, Goldfarb M (October 1996). "Broadly expressed SNT-like proteins link FGF receptor stimulation to activators of Ras". Oncogene 13 (4): 721–9. PMID 8761293. 
  2. ^ a b Xu H, Lee KW, Goldfarb M (August 1998). "Novel recognition motif on fibroblast growth factor receptor mediates direct association and activation of SNT adapter proteins". J Biol Chem 273 (29): 17987–90. doi:10.1074/jbc.273.29.17987. PMID 9660748. 
  3. ^ "Entrez Gene: FRS2 Fibroblast growth factor receptor substrate 2". 
  4. ^ Valencia, T; Joseph, A; Kachroo, N; Darby, S; Meakin, S; Gnanapragasam, VJ (Nov 11, 2011). "Role and expression of FRS2 and FRS3 in prostate cancer.". BMC cancer 11: 484. PMID 22078327. 
  5. ^ Chen, Y; McGee, J; Chen, X; Doman, TN; Gong, X; Zhang, Y; Hamm, N; Ma, X; Higgs, RE; Bhagwat, SV; Buchanan, S; Peng, SB; Staschke, KA; Yadav, V; Yue, Y; Hosein, Kouros-Mehr (2014). "Identification of Druggable Cancer Driver Genes Amplified across TCGA Datasets.". PloS one 9 (5): e98293. PMID 24874471. 
  6. ^ Lim, Y P; Low B C; Lim J; Wong E S; Guy G R (July 1999). "Association of atypical protein kinase C isotypes with the docker protein FRS2 in fibroblast growth factor signaling". J. Biol. Chem. (UNITED STATES) 274 (27): 19025–34. doi:10.1074/jbc.274.27.19025. ISSN 0021-9258. PMID 10383403. 
  7. ^ Ong, S H; Goh K C; Lim Y P; Low B C; Klint P; Claesson-Welsh L; Cao X; Tan Y H; Guy G R (August 1996). "Suc1-associated neurotrophic factor target (SNT) protein is a major FGF-stimulated tyrosine phosphorylated 90-kDa protein which binds to the SH2 domain of GRB2". Biochem. Biophys. Res. Commun. (UNITED STATES) 225 (3): 1021–6. doi:10.1006/bbrc.1996.1288. ISSN 0006-291X. PMID 8780727. 
  8. ^ a b c Wong, Andy; Lamothe Betty; Lee Arnold; Schlessinger Joseph; Lax Irit; Li Arnold (May 2002). "FRS2 alpha attenuates FGF receptor signaling by Grb2-mediated recruitment of the ubiquitin ligase Cbl". Proc. Natl. Acad. Sci. U.S.A. (United States) 99 (10): 6684–9. doi:10.1073/pnas.052138899. ISSN 0027-8424. PMC 124463. PMID 11997436. 
  9. ^ a b Meakin, S O; MacDonald J I; Gryz E A; Kubu C J; Verdi J M (April 1999). "The signaling adapter FRS-2 competes with Shc for binding to the nerve growth factor receptor TrkA. A model for discriminating proliferation and differentiation". J. Biol. Chem. (UNITED STATES) 274 (14): 9861–70. doi:10.1074/jbc.274.14.9861. ISSN 0021-9258. PMID 10092678. 
  10. ^ a b Kouhara, H; Hadari Y R; Spivak-Kroizman T; Schilling J; Bar-Sagi D; Lax I; Schlessinger J (May 1997). "A lipid-anchored Grb2-binding protein that links FGF-receptor activation to the Ras/MAPK signaling pathway". Cell (UNITED STATES) 89 (5): 693–702. doi:10.1016/S0092-8674(00)80252-4. ISSN 0092-8674. PMID 9182757. 
  11. ^ Delahaye, L; Rocchi S; Van Obberghen E (February 2000). "Potential involvement of FRS2 in insulin signaling". Endocrinology (UNITED STATES) 141 (2): 621–8. doi:10.1210/en.141.2.621. ISSN 0013-7227. PMID 10650943. 
  12. ^ Kurokawa, K; Iwashita T; Murakami H; Hayashi H; Kawai K; Takahashi M (April 2001). "Identification of SNT/FRS2 docking site on RET receptor tyrosine kinase and its role for signal transduction". Oncogene (England) 20 (16): 1929–38. doi:10.1038/sj.onc.1204290. ISSN 0950-9232. PMID 11360177. 
  13. ^ Hadari, Y R; Kouhara H; Lax I; Schlessinger J (July 1998). "Binding of Shp2 tyrosine phosphatase to FRS2 is essential for fibroblast growth factor-induced PC12 cell differentiation". Mol. Cell. Biol. (UNITED STATES) 18 (7): 3966–73. ISSN 0270-7306. PMC 108981. PMID 9632781. 
  14. ^ Yan, Kelley S; Kuti Miklos, Yan Sherry, Mujtaba Shiraz, Farooq Amjad, Goldfarb Mitchell P, Zhou Ming-Ming (May 2002). "FRS2 PTB domain conformation regulates interactions with divergent neurotrophic receptors". J. Biol. Chem. (United States) 277 (19): 17088–94. doi:10.1074/jbc.M107963200. ISSN 0021-9258. PMID 11877385. 
  15. ^ Ong, S H; Guy G R; Hadari Y R; Laks S; Gotoh N; Schlessinger J; Lax I (February 2000). "FRS2 proteins recruit intracellular signaling pathways by binding to diverse targets on fibroblast growth factor and nerve growth factor receptors". Mol. Cell. Biol. (UNITED STATES) 20 (3): 979–89. doi:10.1128/MCB.20.3.979-989.2000. ISSN 0270-7306. PMC 85215. PMID 10629055. 
  16. ^ Dhalluin, C; Yan K S; Plotnikova O; Lee K W; Zeng L; Kuti M; Mujtaba S; Goldfarb M P; Zhou M M (October 2000). "Structural basis of SNT PTB domain interactions with distinct neurotrophic receptors". Mol. Cell (United States) 6 (4): 921–9. doi:10.1016/S1097-2765(05)00087-0. ISSN 1097-2765. PMID 11090629. 
  17. ^ Foehr, E D; Tatavos A; Tanabe E; Raffioni S; Goetz S; Dimarco E; De Luca M; Bradshaw R A (May 2000). "Discoidin domain receptor 1 (DDR1) signaling in PC12 cells: activation of juxtamembrane domains in PDGFR/DDR/TrkA chimeric receptors". FASEB J. (UNITED STATES) 14 (7): 973–81. ISSN 0892-6638. PMID 10783152. 

Further reading[edit]