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Fascin homolog 2, actin-bundling protein, retinal (Strongylocentrotus purpuratus)
Symbols FSCN2 ; RFSN; RP30
External IDs OMIM607643 MGI2443337 HomoloGene22722 GeneCards: FSCN2 Gene
RNA expression pattern
PBB GE FSCN2 207204 at tn.png
More reference expression data
Species Human Mouse
Entrez 25794 238021
Ensembl ENSG00000186765 ENSMUSG00000025380
UniProt O14926 Q32M02
RefSeq (mRNA) NM_001077182 NM_172802
RefSeq (protein) NP_001070650 NP_766390
Location (UCSC) Chr 17:
79.5 – 79.5 Mb
Chr 11:
120.36 – 120.37 Mb
PubMed search [1] [2]

Fascin-2 is a protein that in humans is encoded by the FSCN2 gene.[1][2]

This gene encodes a member of the fascin protein family. Fascins crosslink actin into filamentous bundles within dynamic cell extensions. This family member is proposed to play a role in photoreceptor disk morphogenesis. A mutation in this gene results in one form of autosomal dominant retinitis pigmentosa and macular degeneration. Multiple transcript variants encoding different isoforms have been found for this gene.[2]


  1. ^ Bardien-Kruger S, Greenberg J, Tubb B, Bryan J, Queimado L, Lovett M, Ramesar RS (Jun 1999). "Refinement of the RP17 locus for autosomal dominant retinitis pigmentosa, construction of a YAC contig and investigation of the candidate gene retinal fascin". Eur J Hum Genet 7 (3): 332–8. doi:10.1038/sj.ejhg.5200302. PMID 10234509. 
  2. ^ a b "Entrez Gene: FSCN2 fascin homolog 2, actin-bundling protein, retinal (Strongylocentrotus purpuratus)". 

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