FTH1

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Ferritin, heavy polypeptide 1
Protein FTH1 PDB 1fha.png
PDB rendering based on 1fha [1].
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols FTH1 ; FHC; FTH; FTHL6; HFE5; PIG15; PLIF
External IDs OMIM134770 MGI95588 HomoloGene74295 GeneCards: FTH1 Gene
EC number 1.16.3.1
RNA expression pattern
PBB GE FTH1 200748 s at tn.png
PBB GE FTH1 214211 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 2495 14319
Ensembl ENSG00000167996 ENSMUSG00000024661
UniProt P02794 P09528
RefSeq (mRNA) NM_002032 NM_010239
RefSeq (protein) NP_002023 NP_034369
Location (UCSC) Chr 11:
61.73 – 61.74 Mb
Chr 19:
9.98 – 9.99 Mb
PubMed search [1] [2]

Ferritin heavy chain is a ferroxidase enzyme that in humans is encoded by the FTH1 gene.[2][3]

Function[edit]

This gene encodes the heavy subunit of ferritin, the major intracellular iron storage protein in prokaryotes and eukaryotes. It is composed of 24 subunits of the heavy and light ferritin chains. Variation in ferritin subunit composition may affect the rates of iron uptake and release in different tissues. A major function of ferritin is the storage of iron in a soluble and nontoxic state. Defects in ferritin proteins are associated with several neurodegenerative diseases. This gene has multiple pseudogenes. Several alternatively spliced transcript variants have been observed, but their biological validity has not been determined.[3]

Interactions[edit]

FTH1 has been shown to interact with Ferritin light chain.[4][5]

See also[edit]

References[edit]

  1. ^ Lawson, D. M.; Artymiuk, P. J.; Yewdall, S. J.; Smith, J. M. A.; Livingstone, J. C.; Treffry, A.; Luzzago, A.; Levi, S.; Arosio, P.; Cesareni, G.; Thomas, C. D.; Shaw, W. V.; Harrison, P. M. (1991). "Solving the structure of human H ferritin by genetically engineering intermolecular crystal contacts". Nature 349 (6309): 541–544. doi:10.1038/349541a0. PMID 1992356.  edit
  2. ^ Hentze MW, Keim S, Papadopoulos P, O'Brien S, Modi W, Drysdale J, Leonard WJ, Harford JB, Klausner RD (Oct 1986). "Cloning, characterization, expression, and chromosomal localization of a human ferritin heavy-chain gene". Proc Natl Acad Sci U S A 83 (19): 7226–7230. doi:10.1073/pnas.83.19.7226. PMC 386688. PMID 3020541. 
  3. ^ a b "Entrez Gene: FTH1 ferritin, heavy polypeptide 1". 
  4. ^ Rual, Jean-François; Venkatesan Kavitha, Hao Tong, Hirozane-Kishikawa Tomoko, Dricot Amélie, Li Ning, Berriz Gabriel F, Gibbons Francis D, Dreze Matija, Ayivi-Guedehoussou Nono, Klitgord Niels, Simon Christophe, Boxem Mike, Milstein Stuart, Rosenberg Jennifer, Goldberg Debra S, Zhang Lan V, Wong Sharyl L, Franklin Giovanni, Li Siming, Albala Joanna S, Lim Janghoo, Fraughton Carlene, Llamosas Estelle, Cevik Sebiha, Bex Camille, Lamesch Philippe, Sikorski Robert S, Vandenhaute Jean, Zoghbi Huda Y, Smolyar Alex, Bosak Stephanie, Sequerra Reynaldo, Doucette-Stamm Lynn, Cusick Michael E, Hill David E, Roth Frederick P, Vidal Marc (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature (England) 437 (7062): 1173–1178. doi:10.1038/nature04209. PMID 16189514. 
  5. ^ Stelzl, Ulrich; Worm Uwe, Lalowski Maciej, Haenig Christian, Brembeck Felix H, Goehler Heike, Stroedicke Martin, Zenkner Martina, Schoenherr Anke, Koeppen Susanne, Timm Jan, Mintzlaff Sascha, Abraham Claudia, Bock Nicole, Kietzmann Silvia, Goedde Astrid, Toksöz Engin, Droege Anja, Krobitsch Sylvia, Korn Bernhard, Birchmeier Walter, Lehrach Hans, Wanker Erich E (Sep 2005). "A human protein-protein interaction network: a resource for annotating the proteome". Cell (United States) 122 (6): 957–968. doi:10.1016/j.cell.2005.08.029. ISSN 0092-8674. PMID 16169070. 

Further reading[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.