FUSIP1

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Serine/arginine-rich splicing factor 10
Identifiers
Symbols SRSF10 ; FUSIP1; FUSIP2; NSSR; PPP1R149; SFRS13; SFRS13A; SRp38; SRrp40; TASR; TASR1; TASR2
External IDs OMIM605221 MGI1333805 HomoloGene134051 GeneCards: SRSF10 Gene
Orthologs
Species Human Mouse
Entrez 10772 14105
Ensembl ENSG00000188529 ENSMUSG00000028676
UniProt O75494 Q9R0U0
RefSeq (mRNA) NM_001191005 NM_001080387
RefSeq (protein) NP_001177934 NP_001073856
Location (UCSC) Chr 1:
24.29 – 24.31 Mb
Chr 4:
135.86 – 135.87 Mb
PubMed search [1] [2]

FUS-interacting serine-arginine-rich protein 1 is a protein that in humans is encoded by the SFRS13A gene.[1][2][3]

This gene product is a member of the serine-arginine (SR) family of proteins, which is involved in constitutive and regulated RNA splicing. Members of this family are characterized by N-terminal RNP1 and RNP2 motifs, which are required for binding to RNA, and multiple C-terminal SR/RS repeats, which are important in mediating association with other cellular proteins. This protein can influence splice site selection of adenovirus E1A pre-mRNA. It interacts with the oncoprotein TLS, and abrogates the influence of TLS on E1A pre-mRNA splicing. Alternative splicing of this gene results in at least two transcript variants encoding different isoforms. In addition, transcript variants utilizing alternative polyA sites exist.[3]

Interactions[edit]

FUSIP1 has been shown to interact with FUS.[4]

References[edit]

  1. ^ Yang L, Embree LJ, Tsai S, Hickstein DD (November 1998). "Oncoprotein TLS interacts with serine-arginine proteins involved in RNA splicing". J Biol Chem 273 (43): 27761–4. doi:10.1074/jbc.273.43.27761. PMID 9774382. 
  2. ^ Clinton JM, Chansky HA, Odell DD, Zielinska-Kwiatkowska A, Hickstein DD, Yang L (March 2002). "Characterization and expression of the human gene encoding two translocation liposarcoma protein-associated serine-arginine (TASR) proteins". Gene 284 (1–2): 141–7. doi:10.1016/S0378-1119(02)00382-7. PMID 11891055. 
  3. ^ a b "Entrez Gene: FUSIP1 FUS interacting protein (serine/arginine-rich) 1". 
  4. ^ Yang, L; Embree L J; Hickstein D D (May 2000). "TLS-ERG leukemia fusion protein inhibits RNA splicing mediated by serine-arginine proteins". Mol. Cell. Biol. (UNITED STATES) 20 (10): 3345–54. doi:10.1128/MCB.20.10.3345-3354.2000. ISSN 0270-7306. PMC 85627. PMID 10779324. 

Further reading[edit]