FUT6

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Fucosyltransferase 6 (alpha (1,3) fucosyltransferase)
Identifiers
Symbols FUT6 ; FCT3A; FT1A; Fuc-TVI; FucT-VI
External IDs OMIM136836 HomoloGene115802 ChEMBL: 4443 GeneCards: FUT6 Gene
EC number 2.4.1.65
RNA expression pattern
PBB GE FUT6 211465 x at tn.png
PBB GE FUT6 210399 x at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 2528 n/a
Ensembl ENSG00000156413 n/a
UniProt P51993 n/a
RefSeq (mRNA) NM_000150.2 n/a
RefSeq (protein) NP_000141.1 n/a
Location (UCSC) Chr 19:
5.83 – 5.84 Mb
n/a
PubMed search [1] n/a

Alpha-(1,3)-fucosyltransferase is an enzyme that in humans is encoded by the FUT6 gene.[1][2][3]

The alpha-1,3-fucosyltransferases constitute a large family of glycosyltransferases with a high degree of homology. The enzymes of this family comprise 3 main activity patterns called myeloid, plasma, and Lewis, based on their capacity to transfer alpha-L-fucose to distinct oligosaccharide acceptors, their sensitivity to N-ethylmaleimide inhibition, their cation requirements, and their tissue-specific expression patterns. The different categories of alpha-1,3-fucosyltransferases are sequentially expressed during embryo-fetal development.[supplied by OMIM][3]

References[edit]

  1. ^ Koszdin KL, Bowen BR (Oct 1992). "The cloning and expression of a human alpha-1,3 fucosyltransferase capable of forming the E-selectin ligand". Biochem Biophys Res Commun 187 (1): 152–7. doi:10.1016/S0006-291X(05)81472-X. PMID 1520296. 
  2. ^ McCurley RS, Recinos A 3rd, Olsen AS, Gingrich JC, Szczepaniak D, Cameron HS, Krauss R, Weston BW (Jul 1995). "Physical maps of human alpha (1,3)fucosyltransferase genes FUT3-FUT6 on chromosomes 19p13.3 and 11q21". Genomics 26 (1): 142–6. doi:10.1016/0888-7543(95)80094-3. PMID 7782074. 
  3. ^ a b "Entrez Gene: FUT6 fucosyltransferase 6 (alpha (1,3) fucosyltransferase)". 

Further reading[edit]