FUT7

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Fucosyltransferase 7 (alpha (1,3) fucosyltransferase)
Identifiers
Symbols FUT7 ; FucT-VII
External IDs OMIM602030 MGI107692 HomoloGene3296 GeneCards: FUT7 Gene
EC number 2.4.1.-
RNA expression pattern
PBB GE FUT7 210506 at tn.png
PBB GE FUT7 217696 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 2529 14347
Ensembl ENSG00000180549 ENSMUSG00000036587
UniProt Q11130 Q11131
RefSeq (mRNA) NM_004479.3 NM_001177366.1
RefSeq (protein) NP_004470.1 NP_001170837.1
Location (UCSC) Chr 9:
139.92 – 139.93 Mb
Chr 2:
25.28 – 25.28 Mb
PubMed search [1] [2]

Alpha-(1,3)-fucosyltransferase is an enzyme that in humans is encoded by the FUT7 gene.[1][2][3]

The sialyl Lewis x oligosaccharide determinant is an essential component of leukocyte counterreceptors for E-selectin- (MIM 131210) and P-selectin- (MIM 173610) mediated adhesions of leukocytes. This oligosaccharide molecule is displayed on the surfaces of granulocytes, monocytes, and natural killer cells. Formation of leukocyte adhesions to these selectins is an early and important step in the process that ultimately allows leukocytes to leave the vascular tree and become recruited into lymphoid tissues and sites of inflammation.[supplied by OMIM][3]

References[edit]

  1. ^ Natsuka S, Gersten KM, Zenita K, Kannagi R, Lowe JB (Jul 1994). "Molecular cloning of a cDNA encoding a novel human leukocyte alpha-1,3-fucosyltransferase capable of synthesizing the sialyl Lewis x determinant". J Biol Chem 269 (24): 16789–94. PMID 8207002. 
  2. ^ Sasaki K, Kurata K, Funayama K, Nagata M, Watanabe E, Ohta S, Hanai N, Nishi T (Jun 1994). "Expression cloning of a novel alpha 1,3-fucosyltransferase that is involved in biosynthesis of the sialyl Lewis x carbohydrate determinants in leukocytes". J Biol Chem 269 (20): 14730–7. PMID 8182079. 
  3. ^ a b "Entrez Gene: FUT7 fucosyltransferase 7 (alpha (1,3) fucosyltransferase)". 

Further reading[edit]